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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(2): 39-43

Effect of tilorone and its analogues on the change of mitochondrial potential of rat hepatocytes

Zholobak NM, Kavok NS, Bogorad-Kobelska OS, Borovoy IA, Malyukina MY, Spivak MY.

  1. D.K. Zabolotny Institute of Microbiology and Virology of theNational Academy of Sciences of Ukraine, Kyiv, Ukraine;
  2. Institute for Scintillation Materials of the National Academy of Sciencesof Ukraine, Kharkov, Ukraine


The influence of tilorone dihydrochloryde and its analogues – diphenyl derivatives on the changes of transmembrane potential of mitochondrial membranes of the isolated rat hepatocytes has been estimated. Authors have shown a significant increase in mitochondrial potential thirty minutes after the introduction of the test compounds to the cells using the fluorescent probe JC-1. These results indicate the rapid activation with tilorone and its analog – dihydrochloryde 4,4'-bis-[2-(diethylamino)ethoxy]diphenyl – of the RLR signaling pathway. The final stage of this pathway is the cell production of IFN type I. The authors concluded that there is an increasing of the organelles resistance to the extra/intracellular damaging agents under the influence of the test compounds.

Keywords: тилорон, производные дифенила,митохондриальный потенциал, флуоресцентные зонды,гепатоциты крыс.


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