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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(2): 16-26

Study of the impact of omega-3 PUFA on fatty acid composition of heart, respiration and swelling of mitochondria of the heart in diabetes

Zhukovs'ka AS, Shysh AM, Moĭbenko OO.

    O.O. Bogomoletz Institute of Physiology Ukrainian NationalAcademy of Science, Kyiv, Ukraine


We studied the influence of w-3 polyunsaturated fatty acids (PUFAs) on respiration, swelling of rat heart mitochondria and changes in rat heart fatty acid composition in tissue homo-genate in rats with streptozotocin induced diabetes mellitus (diabetes), which was induced by single intraperitoneal ad­ministration of 55 mg/kg streptozotocin. We found that appli­cation of these acids increased parameters of active mitochon-drial respiration V3 at 63.7%, controlled breathing V4 at 30.7% and the rate of phosphorylation by 18.9% in animals with experimental diabetes. We proved their ability to reduce swell­ing of mitochondria in heart at streptozotocin induced diabe­tes. In addition, we established changes of fatty acid composition of cell membranes in hearts under diabetic condi­tions with w-3 PUFAs influence. The obtained results allow to conclude that the w-3 PUFA have a positive effect on func­tional parameters of mitochondria due to stabilization cell membranes of rat heart with diabetes.

Keywords: heart, mitochondria, w-3 polyunsaturated fattyacids, diabetes.


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