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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(1): 93-101

NF-kB activation as a molecular basis of pathological process by metabolic syndrome

Kaĭdashev IP.

    Higher State Educational Establishment of Ukraine“Ukrainian Medical Stomatological Academy”, Poltava, Ukraine
DOI: https://doi.org/10.15407/fz58.01.093

Abstract

The paper examines the formation of evolutionary advanced causal factors set in modern conditions which may cause new pathological condition (state), being implemented through evo­lutionary fixed and standard pathological processes. The analysis of the notion of “metabolic syndrome” and its components has been performed. The correlation between insulin resistance, chronic inflammation, arterial hypertension, endothelial dysfunction and dyslipidemia has been indicated as the manifestations of one pathologic process, the central molecular basis of which is the activation of NF-kB. At the current stage it has been suggested to set up the conception of NF-kB permanent (long-lasting, low grade) activation as a possible model of pathological process.

Keywords: metabolic syndrome, insulin resistance, NF-kB.

Full text: (PDF, in Ukrainian)

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