|
|
|
|
NF-kB activation as a molecular basis of pathological process by metabolic syndrome
Kaĭdashev IP.
Higher State Educational Establishment of Ukraine“Ukrainian Medical Stomatological Academy”, Poltava, Ukraine
DOI: https://doi.org/10.15407/fz58.01.093
![](/images/cite.png)
Abstract
The paper examines the formation of evolutionary advanced causal factors set in modern conditions which may cause new pathological condition (state), being implemented through evolutionary fixed and standard pathological processes. The analysis of the notion of “metabolic syndrome” and its components has been performed. The correlation between insulin resistance, chronic inflammation, arterial hypertension, endothelial dysfunction and dyslipidemia has been indicated as the manifestations of one pathologic process, the central molecular basis of which is the activation of NF-kB. At the current stage it has been suggested to set up the conception of NF-kB permanent (long-lasting, low grade) activation as a possible model of pathological process.
Keywords:
metabolic syndrome, insulin resistance, NF-kB.
References
- Alpern D.E. Pathological physiology. M.: Medicine, 1965 . 434 p.
- Bershtein L.M., Kovalenko I.G. "Metabolically healthy" obese individuals and metabolic signs of obesity in people with normal body weight: what is behind this? . Probl. endocrinology. 2010. N 3 P. 47-51.
CrossRef
- Zaichik A.Sh., Churilov L.P. Fundamentals of general pathology. Part 1. Fundamentals of general pathophysiology. SPb. : ELBY, 1999 .- 624 p.
- Izmaylova O.V., Shlikova O.A., Bobrova I.O., Kaydashev I.P. The sound of polymorphisms of genes TLR2 and TLR4 with the precedence of urogenital infections . Cytology and Genetics. 2011. No. 4. P.29-35.
- Pathological physiology . Ed. Corr. USSR Academy of Medical Sciences N.N. Zayko. K .: Vishcha school, 1985 .- 575 p.
- Abdul-Ghani M.A., Jenkinson C.P., Richardson D.K., Tripathy D., DeFronzo R.A. Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study (VAGES) . Diabetes. 2006. 55. P. 1430-1435.
CrossRef
PubMed
- Alberti K., Zimmer P. Definition, diagnosis and classification of Diabetes mellitus and its complications, part1: diagnosis and classification of diabetes mellitus, provisional report of a World Health Organization consultation . Diabet. Med. 1998. 15. P. 539-553.
CrossRef
- Alberti K.G., Eckel R.H., Grundy S.M., Zimmet P.Z., Cleeman J.I., Donato K.A., Fruchart J.C., James W.P., Loria C.M., Smith S.C Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity . Circulation. 2009. 120. P. 1640-1645.
CrossRef
PubMed
- Alberti K.G., Zimmer P., Shaw J. IDF Epidemiology Task Force Consensus Group. The Metabolic Syndrome a new worldwide definition . Lancet. 2005. 366. P. 1059-1062.
CrossRef
- Bajaj M., DeFronzo R.A. Metabolic and molecular basis of insulin resistance . J. Nucl. Cardiol. 2003. 10. P. 311-323.
CrossRef
- Bays H., Mandarino L., De Fronzo R.A. Role of the adipocytes, FFA, and ectopic fat in the pathogenesis of type 2 diabetes mellitus: PPAR agonists provide a rational therapeutic approach . J. Clin. Endocrinol. Metab. 2004. 89. P. 463-478.
CrossRef
PubMed
- Behrendt D., Ganz P. Endothelial function. From vascular biology to clinical applications . Amer. J. Cardiol. 2002. 21. P. 40L-48L.
- Coletta D.K., Balas B., Chavez A.O., Baig M., Abdul-Ghani M., Kashyap S.R., Folli F., Tripathy D., Mandarino L.J., Cornell J.E., Defronzo R.A., Jenkinson C.P. Effect of acute physiological hyperin-sulinemia on gene expression in human skeletal muscle in vivo . Amer. J. Physiol. Endocrinol. Metab. 2008. 294. P. E910-E917.
CrossRef
PubMed PubMedCentral
- De Alvaro C, Teruel T., Hernandez R., Lorenzo M. Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappa B kinase in a p38 mark-dependent manner . J. Biol. Chem. 2004. 279. P. 17070-17078.
CrossRef
PubMed
- De Fronzo R. A. Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis : the missing links. The Claude Bernard lecture 2009 . Diabetologia. 2010. 53. P.1270-1287.
CrossRef
PubMed PubMedCentral
- Del Prato S., Leonetti F., Simonson D.C. Effect of sustained physiologic hyperinsulinaemia and hypergly-caemia on insulin secretion and insulin sensitivity in man . Ibid. 1994. 37. P. 1025-1035.
CrossRef
PubMed
- Folli F., Bouchie J.L., Kahn C.R., Hansen H., Feener E.P. Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels . J. Clin. Invest. 1997. 100. P. 2158-2169.
CrossRef
PubMed PubMedCentral
- Gao Z., Hwang D., Bataille F., Lefevre M., York D., Quon M.J., Ye J. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex . J. Biol. Chem. 2002. 277. P. 48115-48121.
CrossRef
PubMed
- Garg R., Tripathy D., Dandona P. Insulin resistance as a proinflammatory state: mechanisms, mediators, and therapeutic interventions . Curr. Drug Targets. 2003. 4. P. 487-492.
CrossRef
PubMed
- Gerstein H.C., Miller M.E., Byington R.P., Goff D.C. Jr., Bigger J.T., Buse J.B., Cushman W.C., Genuth S., Ismail-Beigi F., Grimm R.H. Jr., Probsteld J.L., SimonsMorton D.G., Friedewald W.T. Effects of intensive glucosae lowering in type 2 diabetes . N. Engl. J. Med. 2008. 358. P. 2345-2359.
CrossRef
PubMed PubMedCentral
- Golovchenko I., Goalstone M.L., Watson P., Brownlee M., Draznin B. Hyperinsulinemia Enhances Transcriptional Activity of Nuclear Factor-kB Induced by Angiotensin II, Hyperglycemia, and Advanced Glycosylation End Products in Vascular Smooth Muscle Cells . Circulat. Res. 2000. 87. P. 746-762.
CrossRef
PubMed
- Grundy S. M., Cleeman J.I., Daniels S.R., Donato K.A., Eckel R.H., Franklin B.A., Gordon D.J., Krauss R.M., Savage P.J., Smith Jr. S.C., Spertus J.A., Costa F. Diagnosis and management of the metabolic syndrome: An American Heart Association. National Heart, Lung, and Blood Institute Scientific Statement . Circulation. 2005. 112. P. 2735-2752.
CrossRef
PubMed
- Gulli G., Ferrannini E., Stern M., Haffner S., DeFronzo R.A. The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents . Diabetes. 1992. 41. P. 1575-1586.
CrossRef
PubMed
- Holman R.R., Thorne K.I., Farmer A.J., Davies M.J., Keenan J.F., Paul S., Levy J.C. Addition of Biphasic, Prandial, or Basal Insulin to Oral Therapy in Type 2 Diabetes . N. Engl. J. Med. 2007. 357. P. 1716-1730.
CrossRef
PubMed
- Kashyap S., Belfort R., Berria R., Suraamornkul S., Pratipranawatr T., Finlayson J., Barrentine A., Bajaj M., Mandarino L., DeFronzo R., Cusi K. Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes . Amer. J. Physiol. Endocrinol. Metab. 2004. 287. P. E537-E546.
CrossRef
PubMed
- Kaydashev I.P., Rasin A.M., Shlykova O.A., Gorbas' I.M., Smirnova I.P., Petrushov A.V., Rasin M.S. Frequency of Pro12Ala-Polymorphism of the Gene PPARr2 in the Ukrainian Population and Its Possible Relation to the Development of the Metabolic Syndrome . Cytol. and Genet. 2007. 41, N 5. P.298-302.
CrossRef
- Miranda P.J., DeFronzo R.A., Califf R.M., Guyton J.R. Metabolic syndrome: evaluation of pathological and therapeutic outcomes . Amer. Heart J. 2005. 149. P. 20-45.
CrossRef
PubMed
- Naruse K., Shimizu K., Muramatsu M., Toki Y, Miyazaki Y, Okumura K., Hashimoto H., Ito T. Long-term inhibition of NO synthesis promotes atherosclerosis in the hy-percholesterolemic rabbit thoracic aorta. PGH2 does not contribute to impaired endothelium-dependent relaxation . Arterioscler Thromb. 1994. 14. P. 746-752.
CrossRef
PubMed
- National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report . Circulation. 2002. 106. P. 3143-3421.
CrossRef
PubMed
- Oeckinghaus A., Hayden M.S., Ghosh S. Crosstalk in NF-kB signaling pathway . Nat. Immunol. 2011. 12 (8). P. 695-708
CrossRef
PubMed
- Patel A., MacMahon S., Chalmers J., Neal B., Billot L., Woodward M., Marre M., Cooper M., Glasziou P., Grobbee D.E., Hamet P., Harrap S., Heller S., Liu L.S., Mancia G. et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes . New Engl. J. Med. 2008. 358. P. 2560-2725.
- Reaven G. M. Banting Lecture 1988. Role of insulin resistance in human disease . Diabetes. 1988. 37. P. 1594-1607.
CrossRef
PubMed
- Unger R.H. Lipid overload and overflow: metabolic trauma and the metabolic sundrome . Trends Endocrinol. Metab. 2003. 14. P. 398-403.
CrossRef
PubMed
|
|
|
|
|
|
|