Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(1): 61-67

Effects of chronic caloric restriction on the age-associated peculiarities of explorative behaviour in rats

Shakhova OH, Krasnikova OM, Babenko NO.

    Institute of Biology, Kharkov Karazin National University, Ukraine
DOI: https://doi.org/10.15407/fz58.01.061


Abstract

Long-term caloric restriction (CR) has been reported to extend the life spans, delay the onset and decrease the incidence of a broad spectrum of age-associated diseases. However, its ef­fect on rat explorative behaviour is still unclear. In the present study, a number of behavioural measures were continuously monitored in 3-, 12-, 24–25-, 28–29- and 35–44-month-old male Wistar rats that were fed either ad libitum or placed on a caloric restricted diet. A gradual decline in locomotor activity of the ad libitum fed rats has been determined during aging in the open field test. In the CR groups, 3-month-old rats exhib­ited lower levels of exploratory behavior, compared to rats on the control diet. 24-25-month-old CR rats exhibited higher levels of exploratory behaviour, compared to ad libitum fed animals of the same age. Chronic dietary restriction nullified the age-dependent decline in locomotor activity and explor­ative behaviour of rats.

Keywords: caloric restriction, explorative behavior, open fieldtest.

Full text: (PDF, in Ukrainian)

References

  1. Babenko N.A., Semenova Y.A. The effect of a diet enriched with polyunsaturated fatty acids of fish oil on the metabolism of phospholipids and the cognitive functions of old rats . Ros. fiziol. journal them. THEM. Sechenov. 2008. No. 12. P. 1400-1406.
    2.  
  2. Buresh Y., Bureshova O., Houston P. Techniques and basic experiments on the study of the brain and behavior. M.: Higher school., 1991 . 299 p.
    3.  
  3. Gulyaeva N.V., Stepanichev M.Yu. Biochemical correlates of individual typological characteristics of rat behavior . Zh. higher nervous activities. 1997 .- 47, no. 2. P. 239-338.
    4.  
  4. Kogteva G.S., Bezuglov V.V. Unsaturated fatty acids as endogenous bioregulators . Biochemistry. 1998. 63, No. 1. p. 6-15.
    5.  
  5. Kostenkova V.N., Nikolskaya K.A. Comparative characteristics of psychoemotional manifestations in outbred rats and Wistar rats . Zh. higher nervous activities. 2004. 54, No. 5. P. 620-631.
    6.  
  6. Kremenevskaya SI., Gelman V.Ya., Zatsepin E.P. Isolation of various components of the orientational rat reaction under open field conditions . Fiziol. journal them. THEM. Sechenov. 1991. 77, No. 2. P. 124-129.
    7.  
  7. Kulagin D.A., Bolondinsky V.K. Neurochemical aspects of emotional reactivity and motor activity of rats in a new environment . Uspekhi fiziol. sciences. 1986. 17, No. 1. P. 92-108.
    8.  
  8. Markel A.L. On the assessment of the main characteristics of rat behavior in the "open field" test . Zh. higher nervous activities. 1981. 31, no. 2. p. 301-307.
    9.  
  9. Nikitin V.N. Experimental approaches to prolonging life . Results of science and technology: general problems of biology. M., 1984. 4. P. 6-43.
    10.  
  10. Titov S.A., Kamensky A.A. The role of orienting and defensive components in the behavior of white rats in an "open field" . Journal. higher nervous activities. 1980. 30, no. 4. P. 704-709.
    11.  
  11. Frolkis V.V., Bezrukov V.V., Bogatskaya L.N. Brain aging. L .: Nauka, 1991 .- 277 p.
    12.  
  12. Birke L.I., Archer J. Open-field behaviour of oestrus and dioestrous rats: evidence against an emotionally interpretation . Anim. Behav. 1975. 23, N 3. P. 509-512. CrossRef  
  13. Chandler-Laney P.C., Castaneda E., Pritchetta C.E., Smitha M.L., Giddingsa M., Artiga A.I., Boggiano M.M. A history of caloric restriction induces neurochemical and behavioral changes in rats consistent with models of depression . Pharmacol. Biochem. Behav. 2007. 87, N 1. P. 104-114. CrossRef PubMed PubMedCentral
    14.  
  14. Fedorova I., Salem N.J. Omega-3 fatty acids and rodent behavior . Prost. Leukot. Essent. Fatty Acids. 2006. 75, N 4-5. P. 271-289. CrossRef PubMed
    15.  
  15. Fontan-Lozano A., Lopez-Lluch G., Delgado-Garcia J.M., Navas P., Carrion A.M. Molecular bases of caloric restriction regulation of neuronal synaptic plasticity . Nol. Neurobiol. 2008. 38,N 2. P 167-177. CrossRef PubMed
    16.  
  16. Gage F.H. Experimental approaches to age-related cognitive impairments . Neurobiol Aging. 1988. 9, N 5-6. P. 645-655. CrossRef  
  17. Gillette-Guyonnet S., Vellas B. Caloric restriction and brain function . Curr. Opin. Clin. Nutr. Metab. Care. 2008. 11, N 6. P. 686-692. CrossRef PubMed
    18.  
  18. Jang J.W., Kim J.G., Kim H.J., Kim B.T., Kang D.W., Lee J.E. Chronic food restriction in young rats results in depression- and anxiety-like behaviors with de­creased expression of serotonin reuptake transporter . . Brain Res. 2007. 1150. P. 100-107. CrossRef PubMed
    19.  
  19. Li X., Cope M.B., Johnson M.S., Smith D.L., Nagy T.R. Mild calorie restriction induces fat accumulation in female C57BL. 6J mice . Obesity (Silver Spring). 2010. 18, N 3. P. 456-462. CrossRef PubMed PubMedCentral
    20.  
  20. Patel N.V., Finch C.E. The glucocorticoid paradox of caloric restriction in slowing brain aging . Neurobiol. Aging. 2002. 23, N 5. P. 707-717. CrossRef  
  21. Rogers P.J. A healthy body, a healthy mind: long-term impact of diet on mood and cognitive function . Proc Nutr Soc. 2001. 60, N 1. P. 135-143. CrossRef PubMed
    22.  
  22. Siwak C.T., Tapp P.D., Milgram N.W. Effect of age and level of cognitive function on spontaneous and exploratory behaviors in the Beagle dog . Learning and memory. 2010. N 8. P. 317-325. CrossRef PubMed PubMedCentral
    23.  
  23. Sotolongo SP., Carrillo C.P., Carrillo C.C. Memory. An introduction to the study of the cognitive disor­ders in normal and pathological aging . Rev. Neurol. 2004. 38, N 5. P. 469-472.
    24.  
  24. Stewart J., Mitchell J., Kalant N. The effect of life­long food restriction on spatial memory in young and aged Fischer 344 rats measured in the eight-arm radial and the Morris water mazes . Neurobiol Aging. 1989. 10, N 6. P. 669-675. CrossRef  
  25. Walsh R.N., Cummins R.A. The open field test: a critical review . Psychol. Bull. 1976. 83, N 3. P. 482-504. CrossRef PubMed
    26.  
  26. Yanai S., Okaichi Y., Okaichi H. Long-term dietary re­striction causes negative effects on cognitive functions in rats . Neurobiol Aging. 2004. 25, N 3. P. 325-332. CrossRef  
  27. Masoro E.J. Role of hormesis in life extension by caloric restriction . Dose-Response. 2007. 5, N 2. P. 163-173. CrossRef PubMed PubMedCentral
    28.  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.