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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(1): 51-55

Changes in the antioxidant system and level of proinflammatory cytokin IL-1beta in the blood patients of sufferi

Fartushok NV, Khavrona OP, Fedevych YM, Sklyarov OY.

    Danylo Halytskyi Lviv National Medical University, Ukraine


Diabetes mellitus type 1 provokes the development of the oxidative stress, accompanied by the increased level of TBA-active products, activation of NO-synthases and increased production of nitric oxide. Activation of glutathione reductase, decrease of the glutathione peroxidase and super-oxide dismutases activity was observed. This shows a specific disturbance in the functioning of the antioxidant defense system and the augmentation in the concentration of one of the major first line reacting cytokin (IL-1b).

Keywords: За умов цукрового діабету 1-го типу відбуваєтьсяокиснювальний стрес, що підтверджується збільшеннямрівня TБК-реагуючих продуктів, оксиду азоту та активаціїсинтезу NO-синтази. Це підтверджується специфічнимизмінами у функціонуванні антиоксидантної системи захистута збільшенням концентрації цитокіну (IL-1?) як першоїголовної лінії реагування.


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