Changes in the antioxidant system and level of proinflammatory cytokin IL-1beta in the blood patients of sufferi
Fartushok NV, Khavrona OP, Fedevych YM, Sklyarov OY.
Danylo Halytskyi Lviv National Medical University, Ukraine
DOI: https://doi.org/10.15407/fz58.01.051
Abstract
Diabetes mellitus type 1 provokes the development of the oxidative stress, accompanied by the increased level of TBA-active products, activation of NO-synthases and increased production of nitric oxide. Activation of glutathione reductase, decrease of the glutathione peroxidase and super-oxide dismutases activity was observed. This shows a specific disturbance in the functioning of the antioxidant defense system and the augmentation in the concentration of one of the major first line reacting cytokin (IL-1b).
Keywords:
За умов цукрового діабету 1-го типу відбуваєтьсяокиснювальний стрес, що підтверджується збільшеннямрівня TБК-реагуючих продуктів, оксиду азоту та активаціїсинтезу NO-синтази. Це підтверджується специфічнимизмінами у функціонуванні антиоксидантної системи захистута збільшенням концентрації цитокіну (IL-1?) як першоїголовної лінії реагування.
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