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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(1): 51-55


Changes in the antioxidant system and level of proinflammatory cytokin IL-1beta in the blood patients of sufferi

Fartushok NV, Khavrona OP, Fedevych YM, Sklyarov OY.

    Danylo Halytskyi Lviv National Medical University, Ukraine


Abstract

Diabetes mellitus type 1 provokes the development of the oxidative stress, accompanied by the increased level of TBA-active products, activation of NO-synthases and increased production of nitric oxide. Activation of glutathione reductase, decrease of the glutathione peroxidase and super-oxide dismutases activity was observed. This shows a specific disturbance in the functioning of the antioxidant defense system and the augmentation in the concentration of one of the major first line reacting cytokin (IL-1b).

Keywords: За умов цукрового діабету 1-го типу відбуваєтьсяокиснювальний стрес, що підтверджується збільшеннямрівня TБК-реагуючих продуктів, оксиду азоту та активаціїсинтезу NO-синтази. Це підтверджується специфічнимизмінами у функціонуванні антиоксидантної системи захистута збільшенням концентрації цитокіну (IL-1?) як першоїголовної лінії реагування.

References

  1. Beruheim F., Mary L.C. Beruheim, Karl M. Wilbur: The reaction between thiobarbituric acid and the oxidation products of certain lipids . J. Biol. Chem. 1948. 174. P.257-264.
  2. Brownlee M. Biochemistry and molecular cell biology of diabetic complications . Nature. 2001. 414. P.813-820.
  3. Ceriello A., Quagliaro L., DrAmico M., Di Filippo C, Marfella R.,Nappo F.,Beriino L., Rossi F., Giugliano D. Acute hyperglicemia induces nitrotyrosine formation and apoptosis in perfused heart from rat . Diabetes. 2002. 51. P.1076-1082.
  4. Ceriello A. New insights on oxidative stress and diabetsc complications may lead to a “causa” antioxidant therapy . Diabetes Care. 2003. 26. P. 1589-1596.
  5. Ceriello A., Piconi L., Quagliaro L., Wang Y, Schnabel C.A., Ruggles J.A., Gloster M.A., Maggs D.G., Weyer C. Effects of pramlintide on postprandial glucose ex­cursions and measures of oxidative stress in patients with type 1 diabetes . Diabetes Care. 2005. 28. P.632-637.
  6. Corbett J.A., Wang J.L., Sweetland M.A., Lancaster J.R., Mc-Daniel M.L. Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide . J. Clin. Invest. 1992. 90. P. 2384-2391.
  7. Green L.C., David A.W. Analysis of nitrate, nitrite and (15N) nitrate in biological fluids . Anal. Biochem. 1982. 126. P. 131-138.
  8. Mazzanti L., Rabini R.A. Altered platelet membrane dynamic properties in type 1 diabetes . Diabetes. 2005. 46, N 12. P. 2069-2074.
  9. 9. Pacher P., Beckman J.S., Liaudet L. Nitric oxide and peroxynitrite in health and disease Phisiol . Phisid. Rev. 2007. 87. P. 315-424.
  10. 10. Pacher P., Szabo C. Role of preoxynitrite in the pathogenesis of cardiovascular complications of diabetes . Curr. Opin Pharmacol. 2006. 6. P.136-141.
  11. Sandstrom J., Nilsson P., Karlsson R. 10-Told increase in human plasma extracellular superoxide dismutase content caused by amutation in heparin-binding domain . J. Biol. Chem. 1994. 269, N 29. P. 19163-19166.
  12. Suchek C, Fehsel K., Kroncke K.D., Sommer A., Kolb-Bachofen V. Primary cultures of rat islet capillary endothelial cells. Constitutive and cytokine-inducible macrophagelike nitric oxide synthases are expressed and activities regulared by glucose concentration . Amer. J. Pathol.1994. 145. P. 685-695. 13.Sumbajev V.V. Jasinskaja I.M. Vlijanije DDT na aktivnost’ sintazy oksida azota v pecheni, ljohkih i golovnom mozge krys . Sovr. probl. toksikologii. 2000. 3. P. 3-7.
  13. Szabo C. Roles of poly (ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications . Pharmacol Res. 2005. 52. P. 60-71.
  14. Spitaler M.M., Graier W.F. Vasular targets of redox signalling in diabete mellitus . Diabetologia. 2002. 45. P.476-494.
  15. Ursini E., Maiorino M., Gregolin C. The selenoenzyme phospholipids hydroperoxide glutathione peroxidase . Biochem. and Biophys. Acta. 1985. 839. P.62-70.
  16. Wu G., Bazer F.W., Davis T.A., Kim S.W., Li P., Rhoads J.M., Satterfield M.C., Smith S.B., Spencer T.E., Yin Y. Arginine metabolism and nutrition in growth, health and disease . Amino Acids. 2009. 37. P. 153-168.
  17. Zak K.P., Popova W.W. Cytokin and Diabetes type 1 in human body . Ukr. Med. Newspaper. 2006. 1, N 51, I. II. P. 78-88.

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