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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(1): 36-42

The antiviral activity of diphenyl derivatives in different model systems

Bogorad-Kobel's'ka OS, Zholobak NM, Olevins'ka ZM, Spivak MIa

    D.K. Zabolotnyi Institute of microbiology and virusology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz58.01.036


Abstract

In experiments on two model systems L929/VSV and RF/ HSV-1 in vitro we have studied the antiviral activity of new structural analogues of tilorone - 4,4'-bis[2-(diethyl-amino)ethoxy]diphenyl dihydrochloride and 2-methoxy-carbonyl-4-4'-bis[2-(diethylamino)ethoxy]diphenyl dihydro-chloride. In experiments the tested substances were adminis­tered in preventive and therapeutic schemes. The preventive scheme confirms the existence of a correlation between IFN production under the influence of tested substances and their antiviral activity. It is shown that diphenyls are able to inhibit the development of viral cytopathic effect induced by DNA-and RNA-containing viruses. Diphenyl derivatives are less toxic than tilorone and could be considered as promising sub­stances for further research to develop new antiviral drugs.

Keywords: amixine .N, tilorone, diphenyl derivatives, antiviralactivity, DNA-containing viruses, RNA-containing viruses.

Full text: (PDF, in Ukrainian)

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