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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(1): 27-35

Arginase-nitric oxide synthase system changes due to adaptation to swimming in adult and aged rat hearts

Kotsiuruba AV, Korkach IuP, Talanov SO, Basiliuk OV, Stepanenko LG, Sagach VF.

    O.O. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine


We tested the physiological indices of adult rat heart beat for the adaptation to prolonged physical exercise (swimming). It was shown that the stimulation of NO-production in the heart mitochondria of trained adult rats improves both systolic and diastolic heart function. In adult rats trained by swimming the activity of both de novo and salvage enzymes of nitric oxide synthesis studied (iNOS, cNOS , nitratreductase) were in­creased in heart mitochondria , whereas in the old rats only the activity of oxidative de novo enzymes. Training reduced the nitrate pools only in the mitochondria from adult rats and the urea pools in mitochondria from old rats. Intramitochondrial nitrite pools were unchanged. In adult rats, mitochondrial HO pools increased after training, whereas in the old rats they were reduced, the level of uric acid (a marker of xanthinoxydase activity ) in ageing rats after training period was declined. Swimming training resulted in a significant increase in the value of «oxygenation index» in mitochondria of adult rats and de­creased the activity of mitochondrial arginase II. The results suggest that swimming is one of the methods of physical load stimulates NO production in the mitochondria of adult and old rats and therefore could be considered as an effective non-pharmacological tool for correction of mitochondrial dysfunc­tion in adults and aging heart.

Keywords: training, aging, heart, mitochondria, nitric oxide,oxidative metabolism.


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