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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(6): 99-117


Structure and function of biomembranes: influence of nanoparticles

Chekman IS, Simonov PV.

    O.O. Bogomolets National Medical University, Kyiv, Ukraine


Abstract

The up-to-date view on a biomembrane structure and func­tions and the role of lipid, protein and carbohydrate biomembrane components in maintenance of a cell vital activ­ity is summarized in this article. The up-to-date model of a biomembrane structure as a nanocompartmentalized fluid in which lipids and proteins undergo anomalous diffusion is ex­amined. An attention is paid to lipid rafts existence as nanos-caled membrane domains. The analysis of literature and research results concerning the nanonature of ion channels and the mechanism of influence of nanoparticles on a biomembrane is carried out. It is shown that the data on structure and func­tions of a biomembrane and the nature of influence of nanopar-ticles on it is necessary to create new high-performance thera­peutic agents, diagnostic tools and to study nanoobjects’ toxi-cological properties.

Keywords: biomembrane, lipid bilayer, protein, diffusion,lipid raft, nanoparticle

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