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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(6): 65-70

Effect of normobaric hyperoxia on the markers of bone tissue metabolism

Berezovs'kyĭ VIa, Zamors'ka TM, Litovka IH, Ianko RV

    Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine


We studied the influencing of normobaric hyperoxia one hour daily during 14 and 28 days on the bone metabolism for 3- and 12-monthly Wistar male-rats (n =80). It was shown, that breathed normobaric gas mixture with 90% O2 during 14 days significant reducing of C-terminal propeptides of type I collagen levels for 36%, an increasing piridinolin levels for 37% and concentration of C-terminal telopeptides of type I collagen for 8% in the blood serum. We found reliable decreas­ing the concentration of piridinolin levels for 27% in adult rats in the same conditions. The C-terminal propeptides of type I collagen levels did not change in any of the groups’ research. We believe that 14 days normobaric hyperoxia (90%) in young animals accompanied by violation of collagen synthesis. The adult rats were more stable and had no changes after influence the two hyperoxia levels.

Keywords: normobaric hyperoxia, C-terminal propeptides oftype I collagen, C-terminal telopeptides of type I collagen,piridinolin.


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