|
|
|
|
Effect of streptozotocin-induced diabetes and transient global brain ischemia on apoptosis in the thymus of rats
Tkachuk OV
Bukovinian State Medical University, Chernivtsi, Ukraine
DOI: https://doi.org/10.15407/fz57.06.058
Abstract
The influence of incomplete global ischemia-reperfusion of the brain on the activity of pro- and antiapoptotic processes in the thymocytes by the intensity of p53 and Bcl-2 - proteins expressions has been investigated. It has been shown that in the cortical zone of thymus of rats with a four-month diabetes, as well as in the control rats and rats with diabetes mellitus after brain ischemia, the antiapoptotic processes are dominated. In the medullar zone of the gland in rats with diabetes, complicated and uncomplicated with brain ischemia-reperfusion the antiapoptotic mechanisms predominate too, but to a lesser extent than in the cortical zone.
Keywords:
сахарный диабет, ишемия–реперфузияголовного мозга, тимус, апоптоз
References
- Boyajyan A.S., Arakuelova E.A., Ayvazyan V.A., Manukyan L.A. Interleukins and chemokines in acute ischemic stroke, weighed and not burdened by diabetes . Cytokines and inflammation. 2008. 7, No. 1. p. 40-43.2.
- Kamyshny A.M. The effect of experimental diabetes mellitus on the expression features of the immune subunit of the proteasome LPM-2 and proapoptotic protein P53 in the thymus in rats with spontaneous hypertension . Zaporizhia. honey. journal 2009. N 1 (52). p. 17-20.
- Kamyshny A.M., Kolesnik Yu.M., Abramov A.V., Kalinichenko N.A. Characterization of the expression of Bcl-2 protein in the thymus in rats with experimental diabetes mellitus . Klip. anatomy and operative hirurgiya. 2007. N 1. p. 68-71.
- Kamyshny A.M., Kolesnik Yu.M., Abramov A.V. The participation of inducible NO synthase and Bcl-2 protein in the regulation of thymocyte apoptosis in offspring of rats with experimental gestational diabetes . Pathology. 2006. 3, No. 3. p. 23-26.
- Konstantinova N.A., Skvortsova V.I., Eremin I.I., Konstantinova E.V., Komarov A.N. Autoimmune mechanisms in ischemia . Allergology and Immunology. 2005. 6, No. 2. p. 147-149.
- Sashchuk M.M., Tkachuk S.S. Reorganization of the structure of the lymphoid population of the thymus with a separate global ischemic brain and the correction of emoxy-pin in experiment . Klip. anatomy and operative hirurgiya. 2006. 5, No. 3. p 45-51.
- Skibo G.G. The use of various experimental models to study the cellular mechanisms of ischemic brain damage . Pathology. 2004. 1, No. 1. p. 22-30.
- Geenen V., Brilot F. Role the thymus in the development of tolerance and autoimmunity towards the neuroendocrine system . Ann. N.Y.Acad. Sci. 2003. 992. P. 186-195.
CrossRef
PubMed
- Geenen V., Brilot F., Louis C, Hansenne I., Renard Ch., Martens H. Importance of a thymus dysfunction in the pathophisiology of type 1 diabetes . Rev. Med. Liege. 2005. 60, N 5-6. P. 291-295.
- Horwitz M.S., Ilic A., Fine C, Rodriguez E., Sarvetnick N. Presented antigen from damaged pancreatic beta cells activates autoreactive T cells in virus-mediated autoimmune diabetes . J. Clin. Invest. 2002. 109, N 1. P. 79-87.
CrossRef
PubMed PubMedCentral
- Hughes P., Bouillet P., Strasser A. Role of Bim and other Bcl-2 family members in autoimmune and degenerative diseases . Curr. Dir. Autoimmun. 2006. 9. P. 74-94.
CrossRef
- Liadis N., Murakami K., Eweida M., Elford A.R., Sheu L., Gaisano H.Y., Hakem R., Ohashi P.S., Woo M. Caspase-3-dependent P-cell apoptosis in the initiation of autoimmune . Diabet. Mellitus Mol. Cell. Biol. 2005. 25, N 9. P. 3620-3629.
CrossRef
PubMed PubMedCentral
- Lin M., Yin N., Murphy B., Medof M.E., Segerer S., Heeger P.S., Schroppel B. Immune Cell-Derived C3 Is Required for Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin . Diabetes. 2010. 59, N 9. P.2247-2252.
CrossRef
PubMed PubMedCentral
- Marsden V., Strasser A. Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more . Annu. Rev. Immunol. 2003. 21. P. 71-105.
CrossRef
PubMed
- Mic A.A., Mic F.A., Tatu C.A., Ionac M., Ordodi V.L., Paunescu V. Indomethacin inhibits thymic involution in mice with streptozotocin-induced diabetes . Compar. Med. 2007. 57, N 5. P. 476-481.
- Willis S., Day C, Hinds M., Huang D. The Bcl-2- regulated apoptotic pathway . J. Cell. Sci. 2003. 116. P. 4053-4056.
CrossRef
PubMed
|
|
|
|
|
|
|