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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(6): 58-64

Effect of streptozotocin-induced diabetes and transient global brain ischemia on apoptosis in the thymus of rats

Tkachuk OV

    Bukovinian State Medical University, Chernivtsi, Ukraine


The influence of incomplete global ischemia-reperfusion of the brain on the activity of pro- and antiapoptotic processes in the thymocytes by the intensity of p53 and Bcl-2 - proteins expressions has been investigated. It has been shown that in the cortical zone of thymus of rats with a four-month diabe­tes, as well as in the control rats and rats with diabetes mellitus after brain ischemia, the antiapoptotic processes are domi­nated. In the medullar zone of the gland in rats with diabetes, complicated and uncomplicated with brain ischemia-reperfusion the antiapoptotic mechanisms predominate too, but to a lesser extent than in the cortical zone.

Keywords: сахарный диабет, ишемия–реперфузияголовного мозга, тимус, апоптоз


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