Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(6): 46-51

Effect of positive expiratory pressure on pulmonary gas exchange in elderly people with accelerated aging

Korkushko OV, Asanov EO, Dyba IA

    D.F. Chebotariov Institute of Gerontology, National Academy of Medical Science of Ukraine, Kyiv, Ukraine


The reaction of cerebral blood flow during breathing with posi­tive end expiratory pressure in elderly people with physi­ological (24 pers.) and accelerated (26 pers.) aging of the respiratory system were studied. It is shown that in people with accelerated aging of the respiratory system some resistance to expiration improves the efficiency of gas exchange in the lungs. However, breathing with considerable resistance to ex­piration (15 mm water column) in people with accelerated aging of the respiratory system, causing depression of gas exchange in the lungs. Found that people with accelerated aging of the respiratory system decreased pulmonary gas ex-change response to breathing resistance expiration.

Keywords: positive end expiratory pressure, pulmonary gasexchange, accelerated aging.


  1. Anisimov VN Means of prevention of accelerated aging (geroprotectors) . Successes of gerontology. 2000. Issue. 4. P. 55-75.
  3. Silber A.P. Respiratory failure. M .: Medicine, 1989. 512 p.
  5. Cassil VL, Leskin GS, Vyzhigina MA Respiratory support: A guide to artificial and assisted lung ventilation in anesthesiology and intensive care. M .: Medicine, 1997. 320 p.
  7. Korkushko OV, Asanov EO, Pisaruk AV, Chebotarev ND Changes in gas exchange in the lungs in hypoxia in the elderly with physiological and accelerated aging of the respiratory system . Ukr. pulmonol. 2010. N 1. P. 54-56.
  9. Korkushko OV, Pisaruk AV, Lishnevskaya V.Yu., Asanov EA, Chebotaryov MD Age peculiarities of the response of the cardiorespiratory system to hypoxia . Physiol. . 2005. 51, N 6. pp. 11-17.
  11. Korkushko OV, Shatalo VB, Yaroshenko Yu.T. Premature aging: risk factors, diagnostics, prevention, metabolic therapy. Library Practice. doctor. K.: Comrade. DSG Ltd., 2003 52 p.
  13. Putienko J.E. Efficiency of application of positive pressure at the end of exhalation in correction of pulmonary ventilation in patients with bronchial asthma and chronic obstructive bronchitis . Ukr. pulmonol. . 1999. N 2. Pp. 42-44.
  15. Frolkis VV Aging: memories of the future . Treatment and diagnosis. 1998. N 7. P. 14-23.
  17. Frolkis VV Regulation of breathing in old age. In the book: Respiration, gas exchange and hypoxic conditions in the elderly and the elderly. K .: Health, 1975. P. 17-20.
  19. Curtis A.S., Kellogg R.H. Ventilatory response of goats to transient changes in CO and O during acute hy­poxia . Resp. Physiol. 19925. 24, 2N 2. P. 163-171. CrossRef  
  20. Fujiwara M., Abe K., Mashimo T. The effect of posi­tive end-expiratory pressure and continuous positive airway pressure on the oxygenation and shunt fraction during one-lung ventilation with propofol anesthesia . J. Clin. Anesth. 2001. 13. P. 473-477. CrossRef  
  21. Inomata S., Nishikawa T., Saito S., Kihara S. 'Best' PEEP during one-lung ventilation . Brit. J. Anaesth. 1997. 78. P. 754-756. CrossRef PubMed
  23. Pelosi P., Ravagnan I., Giurati G. Positive end-expira­tory pressure improves respiratory function in obese but not in normal subjects during anesthesia and pa­ralysis . Anesthesiology. 1999. 91. P. 1221-1231. CrossRef PubMed
  25. Richard J., Maggiore S., Jonson B. et al. Influence of tidal volume on alveolar recruitment. Respective role of PEEP and a recruitment maneuver . Amer. J. Respir. Crit. Care Med. 2001. 163. P. 1609-1613. CrossRef PubMed

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.