Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(4): 90-95

Autoimmune mechanisms of ovarian pathology

Voznesens'ka TIu, Serdiuk OM, Blashkiv TV, Ianchiĭ RI.

    Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine


The data about premature ovarian failure and autoimmune oophoritis are collected and analysed in the review. The data about experimental models of ovarian autoimmunity: autoim­mune ovarian dysgenenesis, murine experimental autoimmune oophoritis, experimental immune ovarian failure are collected and analysed in the review of the literature.

Keywords: premature ovarian failure, experimental autoim-mune ovarian dysgenenesis, experimental autoimmune oophori-tis, experimental immune ovarian failure.


  1. Alekseeva I., Bryzgan T., Sukhina V., Makogon N., Voznesenskaya T., Grushka N. Changes in the thymus and lymph nodes in immune damage to the ovaries in mice . Problems of reproduction. 2006. 12, N 4. p. 38-41.
  2. Alekseeva I., Voznesenska T., Makogon N., Brizgina T., Sukhina V., Grushka N. Creation and comparative analysis of two models of autoimmune ovarian injury in mice. In the book: These don. II int. Sciences. Conference "Homeostasis: Physiology, Pathology, Pharmacology and Clinic". 2005. P. 95-100.
  3. Aleksieieva IM, Bryzhina TM, Aleksiuk LI, Martynova TV, Sukhina VS. The role of nitric oxide in the development of humoral immune response in mice]. . Fiziol Zh. 2005. 51, N 4. Pp. 13-19.
  4. Makohon NV, Voznesens'ka TIu, Bryzhina TM, Sukhina VS, Hrushka NH, Aleksieieva IM. The protective effect of molsidomin in immune ovarian pathology in mice. . Fiziol Zh. . 2007. 53, N 5. Pp. 29-34.
  5. Yuzko O., Buteyko V., Strelke G., Lapko P., Dalekorey V. Effectiveness of intra-uterine insemination in overcoming female infertility of immune origin . Collection of scientific papers. the works of the Academy's employees postgraduate. education IMRL Thug. 2008. 17, N 4. p. 144-147.
  6. Bachelot A., Rouxel A., Massin N., Dulon J., Courtillot C, Matuchansky C, Badachi Y., Fortin A., Paniel B., Lecuru F., Lefrnre-Belda M.A., Constancis E., Thibault E., Meduri G., Guiochon-Mantel A., Misrahi M., Kuttenn F., Touraine P. Phenotyping and genetic stud­ies of 357 consecutive patients presenting with pre­mature ovarian failure . Eur. J. Endocrinol. 2009. 161, N 1. P. 179-187.
  7. Bagavant H., Adams S., Terranova P., Chang A., Kraemer F.W., Lou Y., Kasai K., Luo A.M., Tung K.S. Autoimmune ovarian inflammation triggered by proinflammatory (Th1) T cells is compatible with normal ovarian function in mice . Biol. Reprod. 1999. 61, N 3. P. 635-642.
  8. Bakalov V.K., Anasti J.N., Calis K.A.,Vanderhoof V.H., Premkumar A., Chen S., Furmaniak J., Smith B.R., Merino M.J., Nelson L.M. Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure . Fertil. Steril. 2005. 84, N 4. P. 958-965.
  9. Berberian V., S6nchez S., S6nchez-Borzone M., Attademo A.M., Lasaga M., Celis M.E. Effect of al-pha-melanotropin hormone on serum levels of luteinizing hormone and progesterone in experimental rat autoimmune oophoritis . Peptides. 2006. 27, N 9. P. 2295-2299.
  10. Casalino-Matsuda S., Durando P., Celis M. Effects of alpha-MSH on progesterone and nitric oxide release by cultured ovarian granulosa cells in experimental rat autoimmune oophoritis . J. Physiol. Biochem. 2002. 58, N 1. P. 25-31.
  11. Chattopadhyay D., Sen M., Katiyar P. Pandey L. Antiovarian antibody in premature ovarian failure . Indian. J. Med. Sci. 1999. 53, N 6. P. 254-258.
  12. del Rio R., Noubade R., Subramanian M., SaligramaN., Diehl S., Rincon M., Teuscher C. SNPs upstream of the minimal promoter control IL-2 expression and are candidates for the autoimmune disease-suscepti­bility locus Aod2. Idd3. Eae3 . Genes Immun. 2008. 9, N 2. P. 115-121.
  13. Fu L., Feng W., Li S., Huang B. ZP3 peptides adminis­tered orally suppress murine experimental autoimmune ovarian disease . J. Reprod. Immunol. 2007. 75, N 1. P. 40-47.
  14. Gleicher N., Weghofer A., Oktay K., Barad D. Do eti­ologies of premature ovarian aging (POA) mimic those of premature ovarian failure (POF)? . Hum. Reprod. 2009. 24, N 10. P. 2395-2400.
  15. Hoek A., Schoemaker J., Drexhage H. Premature ova­rian failure and ovarian autoimmunity . Endocr. Rev. 1997. 18, N 1. P. 107-134.
  16. Kim J., Moon S., Chang Y., Lee J. Autoimmune prema­ture ovarian failure . J. Obstet. Gynaecol. 1995. 21, N 1. P. 59-66.
  17. Li J., Jin H., Zhang F., Du X., Zhao G., Yu Y., Wang B. Treatment of autoimmune ovarian disease by co-ad­ministration with mouse zona pellucida protein 3 and DNA vaccine through induction of adaptive regulatory T cells . J. Gene. Med. 2008. 10, N 7. P. 810-820.
  18. Lou Y, McElveen F., Adams S., Tung K. Altered target organ. A mechanism of postrecovery resistance to murine autoimmune oophoritis . J. Immunol. 1995. 155, N 7. P. 3667-3673.
  19. Nair S., Mastorakos G., Raj S., Nelson L. Murine ex­perimental autoimmune oophoritis develops indepen­dently of gonadotropin stimulation and is primarily localized in the stroma and theca . Amer. J. Reprod. Immunol. 1995. 34, N 2. P. 132-139.
  20. Samy E., Parker L., Sharp C, Tung K. Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node . J. Exp. Med. 2005. 202, N 6. P. 771-781.
  21. Tsigkou A., Marzotti S., Borges .L, Brozzetti A.,Reis F., Candeloro P., Luisa Bacosi M., Bini V., Petraglia F., Falorni A. High serum inhibin concentration discrimi­nates autoimmune oophoritis from other forms of pri­mary ovarian insufficiency . J. Clin. Endocrinol. Metab. 2008. 93, N 4. P. 1263-1269.
  22. Tung K., Garza K., Lou Y, Bagavant H. Autoimmune ovarian disease: mechanism of induction and prevention . . J. Soc. Gynecol. Investig. 2001. 8, N 1. P. 49-51.
  23. Vujovic S. Aetiology of premature ovarian failure . Menopause. Int. 2009. 15, N 2. P. 72-75.
  24. Wardell B.B., Michael S.D., Tung K.S., Todd J.A., Blankenhorn E.P., McEntee K., Sudweeks J.D., Hansen W.K., Meeker N.D., Griffith J.S. Aod1, the immunore-gulatory locus controlling abrogation of tolerance in neonatal thymectomy-induced autoimmune ovarian dysgenesis, maps to mouse chromosome 16 . Proc. Natl. Acad. Sci. USA. 1995. 92, N 11. P. 4758-4762.
  25. Welt C, Falorni A., Taylor A., Martin K., Hall J. Se­lective theca cell dysfunction in autoimmune oophori­tis results in multifollicular development, decreased estradiol, and elevated inhibin B levels . J. Clin. Endocrinol. Metab. 2005. 90, N 5. P. 3069-3076.
  26. Zhang P., Shi Y, Gao X., Wang S., Wang J., Chen Z.J. Clinical analysis of Chinese infertility women with premature ovarian failure . Neuro. Endocrinol. Lett. 2007. 28, N 5. P. 580-584.
  27. Zong W., Thompson C. Necrotic death as a cell fate . Genes Dev. 2006. 20, N 1. P. 1-15.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.