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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(4): 82-89


Nitric oxide synthesis during different stages of competition period in well-trained athletes

Bohdanovs'ka NV, Kotsiuruba AV, Malikov MV

  1. Zaporozhye State University, Ukraine
  2. O.V. Palladin Institute of Biochemistry, National Akademy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz57.04.082


In the study 26 trained male and female sportsmen aged 18-20 years old have been investigated. The sex differences in the degree of the nitric oxide synthesis in various stages of their training and competitive activities were shown. In female sports­men, at the time of maximal functional capacity and adapta­tion (beginning of the competition period), a multi-path nonoxidizing arginine metabolism by arginase was prevailed over the oxidative degradation of L-arginine by cNOS . In females, during dezadaptation period (in the middle and the end of competition), the required level of NO synthesis is maintained mainly by non-oxidative resynthesis of nitric ox­ide from its stable metabolites. In males, however, the level of NO synthesis is maintained mainly by an increase in oxidative degradation of L-arginine with the gradual change in activity of different isoforms of NOS (cNOS as well as iNOS).

Keywords: nitric oxide, arginine, psychical stress, athletes,sex differensis

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