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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(4): 82-89

Nitric oxide synthesis during different stages of competition period in well-trained athletes

Bohdanovs'ka NV, Kotsiuruba AV, Malikov MV

  1. Zaporozhye State University, Ukraine
  2. O.V. Palladin Institute of Biochemistry, National Akademy of Sciences of Ukraine, Kyiv, Ukraine


In the study 26 trained male and female sportsmen aged 18-20 years old have been investigated. The sex differences in the degree of the nitric oxide synthesis in various stages of their training and competitive activities were shown. In female sports­men, at the time of maximal functional capacity and adapta­tion (beginning of the competition period), a multi-path nonoxidizing arginine metabolism by arginase was prevailed over the oxidative degradation of L-arginine by cNOS . In females, during dezadaptation period (in the middle and the end of competition), the required level of NO synthesis is maintained mainly by non-oxidative resynthesis of nitric ox­ide from its stable metabolites. In males, however, the level of NO synthesis is maintained mainly by an increase in oxidative degradation of L-arginine with the gradual change in activity of different isoforms of NOS (cNOS as well as iNOS).

Keywords: nitric oxide, arginine, psychical stress, athletes,sex differensis


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