Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(4): 82-89


Nitric oxide synthesis during different stages of competition period in well-trained athletes

Bohdanovs'ka NV, Kotsiuruba AV, Malikov MV

  1. Zaporozhye State University, Ukraine
  2. O.V. Palladin Institute of Biochemistry, National Akademy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz57.04.082

Abstract

In the study 26 trained male and female sportsmen aged 18-20 years old have been investigated. The sex differences in the degree of the nitric oxide synthesis in various stages of their training and competitive activities were shown. In female sports­men, at the time of maximal functional capacity and adapta­tion (beginning of the competition period), a multi-path nonoxidizing arginine metabolism by arginase was prevailed over the oxidative degradation of L-arginine by cNOS . In females, during dezadaptation period (in the middle and the end of competition), the required level of NO synthesis is maintained mainly by non-oxidative resynthesis of nitric ox­ide from its stable metabolites. In males, however, the level of NO synthesis is maintained mainly by an increase in oxidative degradation of L-arginine with the gradual change in activity of different isoforms of NOS (cNOS as well as iNOS).

Keywords: nitric oxide, arginine, psychical stress, athletes,sex differensis

References

  1. Basiluk OV, Kotsyuruba AV, Stepanenko LG, Talanov CO., Korkach YP, Sagach VF Age-specific features of changes in the aortic and plasma nitric oxide systems under conditions of adaptation to physical activity . Fiziol Zh. 2010. 56, N 1. P. 3-12.
  2.  
  3. Bohdanovs'ka NV, Malikov MV. Functional state of the vascular endotelium during systematic physical loadings. . Fiziol Zh.-2008. 54, N 4. p. 44-46.
  4.  
  5. Bohdanovs'ka NV, Sviatodukh HM, Kotsiuruba AV, Korkach IuP, Malikov MV. Nitric oxide synthesis during long-term adaptation to intensive muscular work in female sportsmen. . Fiziol Zh.- 2009. 55, N 3. Pp. 94-99.
  6.  
  7. Bogdanovskaya NV, Malikov NV, Sviatodukh AN Evaluation of the role of vascular endothelium in the provision of physical fitness of female volleyball players at the stage of intense competitive activity . Visn. Zaporozhye. nat. un-tu Biol. science. 2008. N 1. Pp. 40-43.
  8.  
  9. Karpman VL Sports Medicine: Training. for the in-ts of phys. cult. M .: Physical education and sports, 1980. 230 p.
  10.  
  11. Reutov VP, Sorokina EG NO-synthase and nitrite-reductase components of the nitric oxide cycle . Biochemistry 1998. 63, no. 7. P. 1029-1040.
  12.  
  13. Akita Y., Otani H., Matsuhisa S. Exercice-induced ac­tivation of cardiac sympathetic nerve triggers cardioprotection via redox-sensitive activation of eNOS and upregulation of iNOS . Amer. J. Physiol. 2007. 292,N 5. H2051-H2059. CrossRef PubMed
  14.  
  15. Bianchi P.G., Saccabusi E. Use of 5(4)amino 4(5)imida-zolcarboxamide ureidosuccinate in inflammatory and degenerative liver . Minerva Gastroenterol. 1972. 18, N 4. P. 245-256.
  16.  
  17. Bogdanovskaya N.V., Malikov N.V. Role of the sys­tem of synthesis of nitric oxide in providing of long duration adaptation of organism to muscular work . J. Physiol. Sci. . The XXXVI International Congress of Physiological Sciences Kioto, 2009. P. 442.
  18.  
  19. Diwan A.D., Wang M.X., Jang D. Nitric oxide modu­lates fracture healing . J. Bone Miner Res., 2000. 15, N 2. P. 342-351. CrossRef PubMed
  20.  
  21. Defron D.T., Most D., Barbul A. Role of nitric oxide in wound healing . Curr Opin. Clin. Nutr. Metab. Care, 2000. 3,N 3. P. 197-204. CrossRef PubMed
  22.  
  23. Rassaf T., Lauer T, Heiss S Nitric oxide synthase-derived plasma nitrite predicts exercise capacity . Brit. J. Sports Med. October 1, 2007. 41, N 10. P. 669-673. CrossRef PubMed PubMedCentral
  24.  
  25. Kanno S. Lee P.C., Zhang Y. Attenuation of myocar­dial ischemia. reperfusion injury by superinduction of inducible nitric oxide synthase . Circulation. 2000. 101, N 23. P. 2742-2748. CrossRef PubMed
  26.  
  27. Sessa W.C., Pritchard K.A. Jr., Seyedi N. Chronic ex­ercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression . Circ. Res. 1994. 74. P. 349-353. CrossRef PubMed
  28.  
  29. Sureda A., Tauler P., Aguilo A. Relation between oxi­dative stress and antioxidant endogenous defences dur­ing exhaustive exercise. Free Radic. Res. 2005. 39, N 12. P.1317-1324. CrossRef PubMed
  30.  
  31. Shen W., Zhang X., Zhao G. Nitric oxide production and NO synthase gene expression contribute to vascu­lar regulation during exercise . Med. Sci. Sports Exerc. 1995. 27. P. 1125-1134. CrossRef  
  32. Souza H.C., Penteado D.M., Martin-Pinge M.C. Ni­tric oxide synthesis blockade increases hypertrophy and cardiac fibrosis in rats submitted to aerobic train­ing . Arq Bras Cardiol. 2007. Aug. 89, N 2. P. 88-93, 99-104. CrossRef PubMed
  33.  
  34. Swamy M., Yusot W.R., Sirajudeen K.N. Decreased glutamine synthase, increased citrulline-nitric oxide cycle activities and oxidative stress in different regions of brain in epilepsy rat model . J. Physiol. Biochem. 2011. 67, N 1. P. 105-113. CrossRef PubMed
  35.  
  36. Wildhirt S.M., Weismueller S., Schulze C. Inducible nitric oxidr synthase activation after ischemia. reperfusion contributes to myocardal dysfunction and extent of infarct size in rabbits: evidence for a late phase of nitric oxide-mediated reperfusion injury . Cardiocasc. Res. 1999. 43, N 3. P. 698-711. CrossRef  
  37. Ziche M., Morbidelli L., Choudhuri D.R. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis . J. Clin. Invest. 1997. 99, N 11. P. 2625-2634. CrossRef PubMed PubMedCentral

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2020.