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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(4): 82-89


Peculiarities of the nitric oxide synthesisduring different stages of competition period in athletes of both sexes

N.V. Bogdanovskaya, A.V. Kotsuruba, N.V. MalikoV.

    Запорізьк. ун-т;Ін-т біохімії ім. О.В. Палладіна НАН України, Київ


Abstract

In the study 26 trained male and female sportsmen aged 18-20 years old have been investigated. The sex differences in the degree of the nitric oxide synthesis in various stages of their training and competitive activities were shown. In female sports­men, at the time of maximal functional capacity and adapta­tion (beginning of the competition period), a multi-path nonoxidizing arginine metabolism by arginase was prevailed over the oxidative degradation of L-arginine by cNOS . In females, during dezadaptation period (in the middle and the end of competition), the required level of NO synthesis is maintained mainly by non-oxidative resynthesis of nitric ox­ide from its stable metabolites. In males, however, the level of NO synthesis is maintained mainly by an increase in oxidative degradation of L-arginine with the gradual change in activity of different isoforms of NOS (cNOS as well as iNOS).

Keywords: nitric oxide, arginine, psychical stress, athletes,sex differensis

References

  1. Базілюк О.В., Коцюруба А.В., Степаненко Л.Г., Таланов CO., Коркач Ю.П., Сагач В.Ф. Вікові особливості змін системи оксиду азоту в аорті та плазмі за умов адаптації до фізичних навантажень // Фізіол. журн. - 2010. - 56, № 1. - С 3-12.
  2. Богдановська Н.В., Маліков М.В. Особливостіфункціонального стану судинного ендотелію при систематичних фізичних навантаженнях // Там само. -2008. - 54,№4. -С.44-46.
  3. Богдановська Н.В., Святодух Г.М., Коцюруба А.В., Коркач Ю.П., Маліков М.В. Синтез оксиду азоту у період довгострокової адаптації до інтенсивної м’язової роботи у спортсменок // Там само. - 2009. -55, №3. -С 94-99.
  4. Богдановская Н.В., Маликов Н.В., Святодух А.Н. Оценка роли сосудистого эндотелия в обеспечении физической подготовленности девушек-волейбо­листок на этапе интенсивной соревновательной деятельности // Вісн. Запорізьк. нац. ун-ту Біол. науки. - 2008. -№1. -С. 40-43.
  5. Карпман В.Л. Спортивная медицина: Учеб. для ин-тов физ. культ. - М.: Физкультура и спорт, 1980. - 230 с.
  6. Реутов В.П., Сорокина Е.Г. NOсинтазная и нитритредуктазная компоненты цикла оксида азота // Биохимия - 1998. - 63, вып. 7. - С. 1029-1040.
  7. Akita Y., Otani H., Matsuhisa S. Exercice-induced ac­tivation of cardiac sympathetic nerve triggers cardioprotection via redox-sensitive activation of eNOS and upregulation of iNOS // Amer. J. Physiol. - 2007. -292,№5. - H2051-H2059.
  8. Bianchi P.G., Saccabusi E. Use of 5(4)amino 4(5)imida-zolcarboxamide ureidosuccinate in inflammatory and degenerative liver // Minerva Gastroenterol. - 1972. -18, № 4. - P. 245-256.
  9. 9. Bogdanovskaya N.V., Malikov N.V. Role of the sys­tem of synthesis of nitric oxide in providing of long duration adaptation of organism to muscular work // J. Physiol. Sci. / The XXXVI International Congress of Physiological Sciences - Кіото, 2009. - P. 442.
  10. 10. Diwan A.D., Wang M.X., Jang D. Nitric oxide modu­lates fracture healing // J. Bone Miner Res., 2000. - 15, №2. - P. 342-351.
  11. Defron D.T., Most D., Barbul A. Role of nitric oxide in wound healing // Curr Opin. Clin. Nutr. Metab. Care, 2000. - 3,№3. - P. 197-204.
  12. Rassaf T., Lauer T, Heiss С Nitric oxide synthase-derived plasma nitrite predicts exercise capacity // Brit. J. Sports Med. - October 1, 2007. - 41, № 10. - P. 669-673.
  13. Kanno S. Lee P.C., Zhang Y. Attenuation of myocar­dial ischemia/reperfusion injury by superinduction of inducible nitric oxide synthase // Circulation. - 2000. -101, №23. - P. 2742-2748.
  14. Sessa W.C., Pritchard K.A. Jr., Seyedi N. Chronic ex­ercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression // Circ. Res. - 1994. - 74. - P. 349-353.
  15. Sureda A., Tauler P., Aguilo A. Relation between oxi­dative stress and antioxidant endogenous defences dur­ing exhaustive exercise// Free Radic. Res. - 2005. - 39, №12. - P.1317-1324.
  16. Shen W., Zhang X., Zhao G. Nitric oxide production and NO synthase gene expression contribute to vascu­lar regulation during exercise // Med. Sci. Sports Exerc. -1995. - 27. - P. 1125-1134.
  17. Souza H.C., Penteado D.M., Martin-Pinge M.C. Ni­tric oxide synthesis blockade increases hypertrophy and cardiac fibrosis in rats submitted to aerobic train­ing // Arq Bras Cardiol. - 2007. - Aug. 89, № 2. -P. 88-93, 99-104.
  18. Swamy M., Yusot W.R., Sirajudeen K.N. Decreased glutamine synthase, increased citrulline-nitric oxide cycle activities and oxidative stress in different regions of brain in epilepsy rat model // J. Physiol. Biochem. -2011. - 67, № 1. - P. 105-113.
  19. 19. Wildhirt S.M., Weismueller S., Schulze C. Inducible nitric oxidr synthase activation after ischemia/ reperfusion contributes to myocardal dysfunction and extent of infarct size in rabbits: evidence for a late phase of nitric oxide-mediated reperfusion injury // Cardiocasc. Res. - 1999. - 43, № 3. - P. 698-711.
  20. 20. Ziche M., Morbidelli L., Choudhuri D.R. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis // J. Clin. Invest. - 1997. -99, № 11. P. 2625-2634.

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