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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(4): 57-67

Study of changes in the parametres of oxidative stress, anti-oxidative defence and endothelial dysfunction in acute ischemia-reperfusion of the lower extremities in humans

Kakhanovs'kyĭ EF, Sahach VF

    Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine


We carried out a study on elderly people (70 ± 2,2 years old) operated on as an acute occlusion of the femoral artery at its different anatomical levels. In those people, development of oxidative stress has been shown in injured lower extremity in the process of restoring of circulation. Marked increase in catalase activity in the blood gives evidence for work of the anti-oxidative defence system with tense. We determined an increase in aspartataminotransferase, alaninaminotransferase and creatininkinase in ischemia/reperfusion which are widely used to identify injures in muscular tissues. It has been shown that NO2- content in the blood at reperfusion depended on the level of nitrites and the duration of ischemia. Significant changes in NO metabolite content in the blood of the patients suffering from acute occlusion injures of the arteries in the lower ex­tremities could be related with endothelial dysfunction.

Keywords: оксидативный стресс, антиоксидантнаязащита, ишемия–реперфузия, эндотелиальная дисфункция.


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