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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(4): 3-11


The role and mechanismsof the effect of hydrogen sulfide on contractile activity of vascular smooth muscles in rats

O.M. Semenikhina, O.V. Bazilyuk, YU.P. Korkach, V.F. Sagach.

    Ін-т фізіології ім. О.О. Богомольця НАН України, Київ


Abstract

The effect of endogenous and exogenous hydrogen sulfide (H2S) on contractile activity of vascular smooth muscle (VSM) was studied. The introduction of substrate synthesis H2S L-cys-teine and its donor NaHS in vitro caused concentration-depen­dent relaxation of VSM of aorta and portal vein. Low concentrations of hydrogen sulfide donor (10-5 mol/L) caused vasoconstriction of both types of the vessels. It was shown that the reaction of relaxation of VSM in response to NaHS is independent from endothelium. It was revealed that VSM of portal vein are more sensitive to the effects of H2S than VSM of aorta. Removing of aorta periadventitial adipose tissue showed no relaxation reply to the hydrogen sulfide donor NaHS in 70% of experiments. Some of the cellular mecha­nisms of hydrogen sulfide action were established, namely relaxation of aorta is depended on KATP channel activation. This is manifested by a lack of relaxation of the aortic VSM due to KATP channel inhibitor glibenclamide.

Keywords: сероводород, L-цистеин, NaHS, глибен-кламид, аорта, воротная вена, эндотелий, адвентиция.

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