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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(3): 69-75


Nitric oxide, myoglobin and cell oxygen regimen

K.G .Lyabakh.

    Міжнар. наук.-навч. центр інформ. технологій ісистем, НАН України, Київ


Abstract

The influence of nanomolar concentrations of NO on oxygen regimen of muscle cells was investigated. The intracellular dis­tribution of oxygen consumption rates, pO2, NO and myoglo-bin was calculated by mathematical modeling of diffusion reactions of O2, NO and myoglobin in the muscle cell. The diffusion of O2 and NO from blood vessel surface into cell was taken into account. According to calculations, NO roughly regulates the oxygen regimen of cell, because it increases the tissue pO2 level by inhibition of mitochondria activity in the whole cell space. The presence of myoglobin is capable poten­tially to modulate the influence of NO on oxygen regimen. Myoglobin not only contributes to tissue O2 supply, but it can locally affect the NO concentration. Acting as an NO scavenger under normoxia and as an NO producer under hy-poxia, myoglobin together with NO can provide fine adjustment of muscle oxygen regimen via an increase in tissue pO2 and elimination a mismatch between oxygen supply and de­mand.

Keywords: mathematical modeling, nitric oxide, myoglobin,oxygen, oxygen regimen, myocite.

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