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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(3): 59-61

Changes of NO-ergic activity in the salivary glands of rats under conditions of omeprazole-induced hypergastrinemia

Sukhomlyn AA, Berehova TV, Neporada KS.

  1. Ukrainian Medical Stomatological Academy, Poltava, Ukraine
  2. Taras Shevchenko National University, Kyiv, Ukraine


Under conditions of omeprazole-induced hypergastrinemia the activity of NOS and the concentration of NO2–, the end prod­uct of metabolism of nitric oxide were studied in salivary glands of rats. We detected an increase in NOS activity, reaching a maximum (7,61±0,39 мmol [NO2-]/(g*min) at 14th day of the experiment. At 28th day following omeprazole introduction its activity was 5,76±0,25 мmol [NO2-]/(g*min).

Keywords: salivary glands, omeprazole, hypergastrinemia,NО-synthase, NО, nitrites.


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