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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(3): 49-58


Effect of 1,5-benzodiazepine derivatives on the electrical activity of neurons of the Helix albescens Rossm

Koreniuk II, Iepishkin IV, Hamma TV, Khusainov DR

    Tauryiskyi National University, Simferopol, Ukraine
DOI: https://doi.org/10.15407/fz57.03.049

Abstract

Using a standard technique for intracellular recording of po­tentials, we investigated the influence of two new derivatives of 1,5-benzodiazepine-2-one on the electrical activity of neurons of the Helix albescens Rossm. These substances possess neurotropic properties, the effects were concentration depen­dent in the concentration range 10-6 M – 10-2 and did not de­pend on the type of neurons. We defined the threshold, opti­mum and toxic concentrations for the compounds investigared. Analysis of the total ion current showed that the compounds reduce the rate of inward Na+- and Ca2+ currents and of outward K+-currents.

Keywords: derivatives of 1,5-benzodiazepine-2-one, grapesnail, neuron, electrical activity

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