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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(3): 16-24

The frequency ofallelic polymorphism of matrix gla-protein gene in acute coronary syndrome patients

V.Yu. Garbuzova, V.L. Gurianova, A.N. Parkhomenko, V.E. Dosenko, A.V. Ataman.

    Сум. ун-т;Ін-т фізіології ім. О.О.Богомольця НАН України, Київ;Нац. наук. центр “Інститут кардіології імені академіка М.Д. Стражеска” НАМН України, Київ


Allelic polymorphisms of matrix Gla protein (MGP) gene were determinated in 115 patients with acute coronary syn­drome (ACS) and in 110 practically healthy people. It was shown that interrelation of major homozygotes, heterozy-gotes and minor homozygotes by T-^C MGP promoter polymorphism in patients with ACS were 59,8%, 32,7%, 7,5% and in control 58.7%, 36.7%, 4.6% (P > 0.05 by X2-test); by G—A polymorphism: 42.1%, 45.6%, 12.3% and 41.8%, 54.5%, 3.6% correspondingly (P < 0,05); and by Thr ^Ala exon 4 polymorphism: 42.6%, 43.5%, 13.9% compared to 43.9%, 45.9%, 10.2% in control (P > 0.05). The obtained data show that MGP A/A variant of MGP promoter G^A poly­morphism is a risk factor of ACS in Ukrainian population. These data indicate also that the intensity of calcification influences atherosclerotic injury of coronary artery.

Keywords: матриксный Gla-протеин, однонуклео-тидный полиморфизм, инфаркт миокарда


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