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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(3): 16-24

The frequency of allelic polymorphism of matrix Gla-protein gene in acute coronary syndrome patients

Harbuzova VIu, Hur'ianova VL, Parkhomenko OM, Dosenko VIe, Ataman OV

  1. Sumy State University, Sumy, Ukraine
  2. O.O.Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
  3. National Scietific Center Srtazhesko Institute of Cardiology NAMS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz57.03.016

Abstract

Allelic polymorphisms of matrix Gla protein (MGP) gene were determinated in 115 patients with acute coronary syn­drome (ACS) and in 110 practically healthy people. It was shown that interrelation of major homozygotes, heterozy-gotes and minor homozygotes by T-^C MGP promoter polymorphism in patients with ACS were 59,8%, 32,7%, 7,5% and in control 58.7%, 36.7%, 4.6% (P > 0.05 by X2-test); by G—A polymorphism: 42.1%, 45.6%, 12.3% and 41.8%, 54.5%, 3.6% correspondingly (P < 0,05); and by Thr ^Ala exon 4 polymorphism: 42.6%, 43.5%, 13.9% compared to 43.9%, 45.9%, 10.2% in control (P > 0.05). The obtained data show that MGP A/A variant of MGP promoter G^A poly­morphism is a risk factor of ACS in Ukrainian population. These data indicate also that the intensity of calcification influences atherosclerotic injury of coronary artery.

Keywords: матриксный Gla-протеин, однонуклео-тидный полиморфизм, инфаркт миокарда

Full text: (PDF, in Ukrainian)

References

  1. Price P.A., Urist M.R., Otawara Y. Matrix Gla pro­tein, a new g-carboxyglutamic acid-containing protein which is associated with the organic matrix of bone . Biochem. Biophys. Res. Commun. 1983. 117. P. 765-771. CrossRef  
  2. Fraser J.D., Price P.A. Lung, heart, and kidney express high levels of mRNA for the vitamin K-dependent matrix Gla protein . J. Biol. Chem. 1988. 263. P. 11033-11036.
    3.  
  3. Price P.A., Faus S.A., Williamson M.K. Warfarin-iduced artery calcification is accelerated by growth and vitamin D . Arterioscler. Thromb. Vasc. Biol. 2000. 20. P. 317-327.4. Price P.A., Williamson M.K. Primary structure of bo­vine matrix Gla protein, a new vitamin K-dependent bone protein . J. Biol. Chem. 1985. 260. P. 14971-14975. CrossRef PubMed
    4.  
  4. Proudfoot D., Shanahan CM. Molecular mechanisms mediating vascular calcification: role of matrix Gla pro­tein . Nephrology (Carlton). 2006. 11. P. 455-461. CrossRef PubMed
    5.  
  5. Cancela L., Hsiehg C. L., Francket U., Price P.A. Mo­lecular structure, chromosome assignment, and pro­moter organization of the human matrix Gla protein gene . J. Biol. Chem. 1990. 265. P. 15040-15048.
    6.  
  6. Herrmann S.M., Whatling C, Brand E., Nikaud V., Gariepy J., Simon A., Evans A., Ruidavets L.B., Arveiler D., Luc G., Tiret L., Henney A., Cambien F. Polymorphisms of the human matrix Gla protein (MGP) gene, vascular calcification, and myocardial infarction . Arterioscler. Thromb. Vasc. Biol. 2000. 20. P. 2386-2393. CrossRef PubMed
    7.  
  7. Farzaneh-Far A., Davies J.D., Braam L.A., Spronk H.M., Proudfoot D., Chan S.W., O'Shaughnessy K.M., Weissberg P.L., Vermeer C, Shanaham CM. A Poly­morphism of the human matrix g-carboxyglutamic acid protein promoter alters binding of an activating pro-tein-1 complex and is associated with altered transcrip­tion and serum levels . J. Biol. Chem. 2001. 276. P. 32466-32473. CrossRef PubMed
    8.  
  8. Kobayashi N., Kitazawa R., Maeda S., Schurgers L.J., Kitazawa S. T-138C polymorphism of matrix Gla pro­tein promoter alters its expression but is not directly associated with atherosclerotic vascular calcification . Kobe J. Med. Sci. 2004. 50. P. 69-81.
    9.  
  9. Brancaccio D., Biondi M.L., Gallieni M., Turri O., Galassi A., Cecchini F., Russo D., Andreucci V., Cozzolino M. Matrix GLA protein gene polymor­phisms: clinical correlates and cardiovascular mortal­ity in chronic kidney disease patients . Amer. J. Nephrol. 2005. 25. P. 548-552. CrossRef PubMed
    10.  
  10. Hernandez-Pacheco G., Murguia L.E., Rodriguez-Pe­rez J.M., Fragoso J.M., Perez-Vielma N., Martinez-Rodriguez N., Granados J., Vargas-Alarcyn G. Matrix gamma-carboxyglutamic acid protein (MGP) G-7A and T-138C gene polymorphisms in Indian (Mayo and Teenek) and Mestizo populations from Mexico . Hum. Biol. 2005. 77. P. 385-391. CrossRef PubMed
    11.  
  11. Taylor B.C., Schreiner P.J., Doherty T.M., Fornage M., Carr J.J., Sidney S. Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA study . Hum. Genet. 2005. 116. P. 525-528. CrossRef PubMed
    12.  
  12. Crosier M.D., Booth S.L., Peter I., Dawson-Hughes B., Price P.A., O'Donnell C.J., Hoffmann U., Wiilliamson M.K., Ordovas J.M. Matrix Gla protein polymorphisms are associated with coronary artery calcification . J. Nutr. Sci. Vitaminol. 2009. 55. P. 59-65. CrossRef PubMed PubMedCentral
    13.  
  13. Schurgers L.J., Teunissen K.J.F., Knapen M.H.J., Kwaijtaal M., van Diest R., Appels A., Reutelingsperger C.P., Cleutjens J.P.M., Vermeer C. Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein . Arterioscler. Thromb. Vasc. Biol. 2005. 25. P. 1629-1633. CrossRef PubMed
    14.  
  14. Stanford W. Coronary artery calcification as an indica­tor of preclinical coronary artery disease . Radiogra-phics. 1999. 19. P. 1409-1419. CrossRef PubMed
    15.  
  15. Shanahan C.M., Proudfoot D., Tyson K.L., Cary N. R. B., Edmonds M., Weissberg P. L. Expression of mineralisation-regulating proteins in association with human vascular calcification . Z. Kardiol. 2000. 89, Suppl. 2. P. II. 63-II. 68. CrossRef PubMed
    16.  
  16. Giachelli C.M. Vascular calcification mechanisms . J. Amer. Soc. Nephrol. 2004. 15. P. 2959-2964. CrossRef PubMed
    17.  
  17. Bertrand ME, Simoons ML, Fox KA, Wallentin LC, Hamm CW, McFadden E, De Feyter PJ, Specchia G, Ruzyllo W. Management of acute coronary syndromes in patients presenting without persistent ST-segment el­evation. The Task Force on the Management of Acute Coronary Syndromes of the European Society of Cardiology . Eur. Heart J. 2002. 23. P.1809-1840.
    18.  
  18. Antman E.M., Hand M., Armstrong P.W., Bates E.R., Green L.A., Halasyamani L.K., Hochman J.S., Krumholz H.M., Lamas G.A., Mullany C.J., Pearle D.L., Sloan M.A., Smith S.C. Jr; 2004 Writing Committee Members, Anbe D.T., Kushner F.G., Ornato J.P., Jacobs A.K., Adams C.D., Anderson J.L., Buller C.E., Creager M.A., Ettinger S.M., Halperin J.L., Hunt S.A., Lytle B.W., Nishimura R., Page R.L., Riegel B., Tarkington L.G., Yancy C.W. ACC. AHA guidelines for the management of patients with ST-elevation myocardial infarction . J. Amer. Coll. Cardiol. 2004. 44. P.E1-211.
    19.  
  19. Thygesen K., Alpert J.S., White H.D.; Joint ESC. ACCF. AHA. WHF Task Force for the Redefinition of Myocar-dial Infarction, Jaffe A.S., Apple F.S., Galvani M., Katus H.A., Newby L.K., Ravkilde J., Chaitman B., Clemmensen P.M., Dellborg M., Hod H., Porela P., Underwood R., Bax J.J., Beller G.A., Bonow R., Van der Wall E.E., Bassand J.P., Wijns W., Ferguson T.B., Steg P.G., Uretsky B.F., Williams D.O., Armstrong P.W., Antman E.M., Fox K.A., Hamm C.W., Ohman E.M., Simoons M.L., Poole-Wilson P.A., Gurfinkel E.P., Lopez-Sendon J.L., Pais P., Mendis S., Zhu J.R., Wallentin L.C., Fernandez-Aviles F., Fox K.M., Parkhomenko A.N., Priori S.G., Tendera M., Voipio-Pulkki L.M., Vahanian A., Camm A.J., De Caterina R., Dean V. , Dickstein K., Filippatos G., Funck-Brentano C., Hellemans I., Kristensen S.D., McGregor K., Sechtem U., Silber S., Tendera M., Widimsky P. , Zamorano J.L., Morais J., Brener S., Harrington R., Morrow D., Lim M., Martinez-Rios M.A., Steinhubl S., Levine G.N., Gibler W.B., Goff D., Tubaro M., Dudek D., Al-Attar N. Universal definition of myocardial infarction . European Heart J. 2007. 28. P.2525-2538. CrossRef PubMed
    20.  
  20. Braam L.A., Dissel P., Gijsbers B.L., Spronk H.M.H., Hamulyak K., Soute B.A.M., Debie W., Vermeer C. As­say for human matrix Gla protein in serum. Potentialapplications in the cardiovascular field . Arterioscler. Thromb. Vasc. Biol. 2000. 20. P. 1257-1261. CrossRef PubMed
    21.  
  21. Jono S., Vermeer C., Dissel P. , Hasegava K., Shioi A., Taniwaki H., Kizu A., Nishizawa Y., Saito S. Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography . Thromb. Haemost. 2004. 91. P. 790-794. CrossRef PubMed
    22.  
  22. O'Donnell C.J., Kyla Shea M., Price P.A., Gagnon D.R., Wilson P.W.F., Larson M.G., Kiel D.P., Hoffmann U., Ferencik M., Clouse M.E., Williamson M.K., Cupples L.A., Dawson-Hughes B., Booth S.L. Matrix Gla protein is associated with risk factors for athero­sclerosis but not with coronary artery calcification) . Arterioscler. Thromb. Vasc. Biol. 2006. 26. P. 2769-2774. CrossRef PubMed PubMedCentral
    23.  
  23. Krueger T., Westenfeld R., Schurgers L.J., Brandenburg V.M. Coagulation meets calcification: The vitamin K system . Int. J. Artif. Organs. 2009. 32. P. 67-74. CrossRef PubMed
    24.  
  24. Wallin R., Schurgers L., Wajih N. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification . Thromb. Res. 2008. 122. P. 411-417. CrossRef PubMed PubMedCentral
    25.  
  25. Uotila L. The metabolic functions and mechanism of action of vitamin K . Scand. J. Clin. Lab. Invest. 1990. 201, Suppl. P. 109-117. CrossRef  
  26. Abedin M., Tintut Y. , Demer L.L. Vascular calcification. Mechanisms and clinical ramifications . Arterioscler. Thromb. Vasc. Biol. 2004. 24. P. 1161-1170. CrossRef PubMed
    27.  
  27. Doherty T.M., Fitzpatrick L.A., Inoue D., Qiao J.H., Fishbein M.C., Detrano R.C., Shah P.K., Rajavashisth T.B. Molecular, endocrine, and genetic mechanisms of arterial calcification . Endocrine Rev. 2004. 25. P. 629-672. CrossRef PubMed
    28.  
  28. Shao J.S., Cai J., Towler D.A. Molecular mechanisms of vascular calcification: lessons learned from the aorta . Arterioscler. Thromb. Vasc. Biol. 2006. 26. P. 1423-1430. CrossRef PubMed
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