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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(3): 16-24


The frequency of allelic polymorphism of matrix Gla-protein gene in acute coronary syndrome patients

Harbuzova VIu, Hur'ianova VL, Parkhomenko OM, Dosenko VIe, Ataman OV

  1. Sumy State University, Sumy, Ukraine
  2. O.O.Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
  3. National Scietific Center Srtazhesko Institute of Cardiology NAMS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz57.03.016

Abstract

Allelic polymorphisms of matrix Gla protein (MGP) gene were determinated in 115 patients with acute coronary syn­drome (ACS) and in 110 practically healthy people. It was shown that interrelation of major homozygotes, heterozy-gotes and minor homozygotes by T-^C MGP promoter polymorphism in patients with ACS were 59,8%, 32,7%, 7,5% and in control 58.7%, 36.7%, 4.6% (P > 0.05 by X2-test); by G—A polymorphism: 42.1%, 45.6%, 12.3% and 41.8%, 54.5%, 3.6% correspondingly (P < 0,05); and by Thr ^Ala exon 4 polymorphism: 42.6%, 43.5%, 13.9% compared to 43.9%, 45.9%, 10.2% in control (P > 0.05). The obtained data show that MGP A/A variant of MGP promoter G^A poly­morphism is a risk factor of ACS in Ukrainian population. These data indicate also that the intensity of calcification influences atherosclerotic injury of coronary artery.

Keywords: матриксный Gla-протеин, однонуклео-тидный полиморфизм, инфаркт миокарда

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