Insulin resistance and physical performance in middle age and elderly people
Korkushko OV, Ishchuk VO, Shatylo VB, Chyzhova VP
Institute of Gerontology AMS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz57.03.010
Abstract
In 43 middle age and elderly people without obesity (body mass index of less than 30 kg/m2) we studied the relationship between insulin resistance (IR) and physical performance. It is shown that in healthy elderly IR is associated with a moderate increase of insulin and a small increase in the level of glucose in the blood plasma. In the middle age people, IR has no effect on physical performance. IR in the elderly people is accompanied by the decrease in physical performance due to less economical for hemodynamic load and oxygen consumption. A lower exercise tolerance in elderly people without obesity can be considered not only as a risk factor for insulin resistance, but also as its consequence.
Keywords:
physical performance, insulin resistance, middleage, elderly
References
- Korkushko OV, Pysaruk AV, Shatylo VB, Iaroshenko IuT. The characteristics of energy substrate utilization during long-term physical loading in elderly men. . Fiziol Zh. 1995. 41, No. 1-2. p. 92-99.
- Shatilo VB Mechanisms of reducing the resilience of elderly people to stress factors and possible ways of correction: Abstract. diss. ... Dr. honey. Sciences: 14.03.03; Kiev. Institute of Gerontology AMS of Ukraine. K., 2002. 42 p.
- Chen C.N., Chuang L.M., Wu Y.T. Clinical measures of physical fitness predict insulin resistance in people at risk for diabetes . Phys. Ther. 2008. 88. P. 1355-1364.
CrossRef
PubMed
- Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: Executive summary. Expert panel on the identification, evaluation, and treatment of overweight in adults . Amer. J. Clin Nutr. 1998. 68. P. 899-917.
CrossRef
PubMed
- Deshpande A.D., Dodson E.A., Gorman I., Brownson R.C. Physical activity and diabetes: opportunities for prevention through policy . Phys. Ther. 2008. 88. P. 1425-1435.
CrossRef
PubMed
- D'Orazio P., Burnett R.W., Fogh-Andersen N. International federation of clinical chemistry scientific division working group on selective electrodes and point of care testing. Approved IFCC recommendation on reporting results for blood glucose (abbreviated) . Clin. Chem. 2005. 51, N 9. P. 1573-1576.
CrossRef
PubMed
- Grundy S.M., Cleeman J.I., Merz C.N. B. For the coordinating committee of the national cholesterol education program; national heart, lung, and blood institute; American college of cardiology foundation; American heart association. Implications of recent clinical trials for the national cholesterol education program adult treatment panel III guidelines . Circulation. 2004. 10. P. 227-239.
CrossRef
PubMed
- Heilbronn L.K., Gan S.K., Turner N. Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects . J. Clin. Endocrinol. Metab. 207. 92. P. 1467-1473.
CrossRef
PubMed
- Huffman D.M., Barzilai N. Role of visceral adipose tissue in aging . Biochim. Biophys. Acta. 2009. 1790 (10). P. 1117-1123.
CrossRef
PubMed PubMedCentral
- Huggett R.J., Burns J., Mackintosh A.F., Mary D.A. Sympathetic neural activation in nondiabetic metabolic syndrome and its further augmentation by hypertension . Hypertension. 2004. 44 (6). P. 847-852.
CrossRef
PubMed
- Jenkins A.B., Furler S.M., Bruce D.G., Chisholm D.J. Regulation of hepatic glucose output during moderate exercise in non-insulin-dependent diabetes . Metabolism. 1988. 37 (10). P. 966-972.
CrossRef
- Kondo N., Nomura M., Nakaya Y. Association of inflammatory marker and highly sensitive c-reactive protein with aerobic exercise capacity, maximum oxygen uptake and insulin resistance in healthy middle-aged volunteers . Circulat. J. 2005. 69. P. 452-457.
CrossRef
PubMed
- Matthews D.R., Hosker J.P., Rudenski A.S. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man . Diabetologia. 1985. 28. P. 412-419.
CrossRef
PubMed
- Mustelin L., Pietilainen K.H., Rissanen A., Sovijarvi A.R. Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity . Amer. J. Physiol. Endocrinol. Metab. 2008. 295. P. E148-E154.
CrossRef
PubMed PubMedCentral
- Perreault L., Ma Y., Dagogo-Jack S. Sex differences in diabetes risk and the effect of intensive lifestyle modification in the Diabetes Prevention Program . Diabetes. Care. 2008. 31 (7). P. 1416-1421.
CrossRef
PubMed PubMedCentral
- Quinn L. Mechanisms in the development of type 2 diabetes mellitus . J. Cardiovasc. Nurs. 2002. 16. P. 1-16.
CrossRef
PubMed
- Reaven G. Banting lecture 1988. Role of insulin resistance in human disease . Diabetes. 1988. 37 (12). P. 1595-1607.
CrossRef
PubMed
- Verity L.S., Ismail A.H. Effects of exercise on cardiovascular disease risk in women with NIDDM . Diabetes. Res. Clin. Pract. 1989. 6 (1). P. 27-35.
CrossRef
- von Dobeln W., Astrand I., Bergstrom A. An analysis of age and other factors related to maximal oxygen uptake . J. Appl.Physiol. 1967. 22. P. 934-938.
CrossRef
PubMed
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