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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(2): 43-48

Comparative characteristic of energy supply disturbances in arterial and venous walls of rabbits with alloxan diabetes and monoiodacetate intoxication

Ataman OV, Ataman IuO

    Sumy Universuty of Ministry of Education and Science, Ukraine
DOI: https://doi.org/10.15407/fz57.02.043


Abstract

We showed here that energy metabolism in thoracic rabbit aorta and posterior vena cava is disturbed two weeks follow­ing the induction of alloxan-induced diabetes and monoiod-acetate intoxication. In the vessels studied, the alterations are manifested in the decrease in the intensity of glucose uptake, oxygen consumption, lactic acid production, and ATP resynthesis. Simultaneously, the ATP content is significantly reduced. The possible significance of these disorders in the development of Monckeberg’s arteriosclerosis is discussed.

Keywords: arteries, veins, alloxan diabetes, monoiodacetate,Monckeberg’s arteriosclerosis.

Full text: (PDF, in Ukrainian)

References

  1. Ataman OV Venous wall: general theoretical and experimental aspects. Sums: Angio, 2001. 248 p.
    2.  
  2. Being Yu.V., Pishak VP, Ataman AV Comparative pathophysiological aspects of energy supply to the vascular wall. K. Chernivtsi: Prut, 1999. 330 p.
    3.  
  3. Voskoboynikov GV Electrophoretic Separation and Calculation of Acid-Soluble Nucleotides from Animal Tissues. honey. chemistry. 1970. 16, N 3. P. 323-326.
    4.  
  4. Gubler EV, Genkin AA Application of nonparametric statistics criteria in biomedical research. L .: Medicine, 1973. 141 p.
    5.  
  5. Labori A. Regulation of exchange processes. M .: Medicine, 1970. 438 p.
    6.  
  6. Trinus FP Methods for simultaneous registration of contraction and respiration of isolated vascular muscle . Pharmacology and Toxicology. 1963. 26, N 3. P. 375-377.
    7.  
  7. Urbach V.Yu. Statistical analysis in biological and medical research. M .: Medicine, 1975. 295 p.
    8.  
  8. Webb L. Enzyme inhibitors and metabolism. M .: The World, 1966. 654 p.
    9.  
  9. Buse M.G. Hexosamines, insulin resistance, and the complications of diabetes: current status . Amer. J. Physiol. Endocrinol. Metabol. 2006. 290. P. E1-E8. CrossRef PubMed PubMedCentral
    10.  
  10. Chen N.X., Moe S.M. Arterial calcification in diabetes . Curr. Diab. Rep. 2003. 3. P. 28-32. CrossRef PubMed
    11.  
  11. Dahlkvist H.H., Arnqvist H.J., Norrby K. Influence of diabetes on oxidation of exogenous substrates in rat aorta . Diabete Metabol. 1981. 7. P. 275-281.
    12.  
  12. Dische Z., Laszlo D. bber eine neue kolorimetrische Bestimmungsmethode der Milchsflure im Blute . Bioch. Zeitschrift. 1927. 187. S. 344-362.
    13.  
  13. Edmonds M.E. Medial arterial calcification and diabe­tes mellitus . Z. Kardiol. 2000. 89. P. 101-104. CrossRef PubMed
    14.  
  14. Everhart J.E., Pettitt D.J., Knowler W.C., Rose F.A., Bennett P.H. Medial arterial calcification and its asso­ciation with mortality and complications of diabetes . . Diabetologia. 1988. 31. P. 16-23.
    15.  
  15. Fuchs U., Caffier P., Schulz H.G., Wieniecki P. Arterial calcification in diabetics . Virch. Arch. 1985. 407. P. 431-439. CrossRef PubMed
    16.  
  16. Gleissner C.A., Galkina E., Nadler J.L., Ley K. Mecha­nisms by which diabetes increases cardiovascular dis­ease . Drug Discov. Today Dis, Mech. 2007. 4. P. 131-140. CrossRef PubMed PubMedCentral
    17.  
  17. Morrison A.D., Clements R.S., Winegrad A.I. Effects of elevated glucose concentrations on the metabolismn of the aortic wall . J. Clin. Invest. 1972. 51. P. 3114-3123. CrossRef PubMed PubMedCentral
    18.  
  18. Peterson J.W., Paul R.J. Aerobic glycolysis in vascular smooth muscle: relation to isometric tension . Biochim. and Biophys. Acta. 1974. 357. P. 167-176. CrossRef  
  19. Rolo A.P., Palmeira CM. Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress . Toxicol. Appl. Pharmacol. 2006. 212. P. 167-178. CrossRef PubMed
    20.  
  20. Sato T.R., Thomson J.F., Dantorth W.F. Electrochro-matographic separation of inorganic phosphate, adenos­ine monophosphate, adenosine diphosphate, adenosine triphosphate . Anal. Biochem. 1963. 5. P. 542-547. CrossRef  
  21. Winegrad A.I., Yalcin S., Mulcahy P.D. Alterations in aortic metabolism in diabetes . On the nature and treat­ment of diabetes. Amsterdam etc.: Excerpta medica foundation, 1965. P. 452-462.
    22.  
  22. Yalcin S., Winegrad A.I. Defect in glucose metabolism in aortic tissue from alloxan diabetic rabbits . Amer. J. Physiol. 1963. 205. P. 1253-1259. CrossRef PubMed
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