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Elevated level of tgf-alpha in rat small intestinalmucosa following massive small bowel resection
A. A. Philchenkov
R. E. Kavetsky Institute of Experimental Pathology, Oncology and RadiobiologyNational Academy of Science of Ukraine, Kiev
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Abstract
A. A. Philchenkov
ELEVATED LEVEL OF TGF-ALPHA IN RAT SMALL INTESTINAL
MUCOSA FOLLOWING MASSIVE SMALL BOWEL RESECTION
This study was performed to determine the changes in TGF-alpha production during
compensatory regeneration of small intestine. For this purpose rats underwent either
70% small bowel resection or sham operation. Levels of TGF-alpha production were
evaluated by radioreceptor assay and Western blotting. When compared with sham
operation, small bowel resection resulted in threefold increase in the production of
TGF-alpha at postoperative day 3. Possible mechanisms of TGF-alpha involvement in
intestinal adaptation following massive small bovel resection are discussed.
R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
National Academy of Science of Ukraine, Kiev
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