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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(2): 35-42

Metabolic activity of neutrophilic granulocytes and possible ways of its correction in patients with acute coronary syndrome

Ryzhkova NA, Havrylenko TI, Parkhomenko OM, Kozhukhov SM

    M.D. Strazhesko Institute of Cardiology, AMS of Ukraine, Kyiv


The present study aimed to investigate the metabolic activity of neutrocytes and the action of corvitin on the level of super-oxide anion and myeloperoxidases of cells in vitro with the calculation of index of consumption of myeloperoxidase in patients with ST-elevation acute coronary syndrome. Patient were divided into 2 groups according to the level of superoxide anion. Group 1 included the patients (68 %) with the initially low level of superoxide anion, and adding of corvitin to the cells of such patients promoted normalization of this index. In this group we observed also neutrocytosis, low index of consumption of myeloperoxidase and a high level of this enzyme in general population of neutrocytes. Group 2 in­cluded patients (32 %) with initially normal level of superox­ide anion. In this group, corvitin did not influence substan­tially this factor. Such patients had a level of myeloperoxidase within control values and the index of consumption of this enzyme was also within control values. The analysis of hospi­tal period showed that the patients of group 1 had a higher frequency of ventricular tachycardia / ventricular fibrillation, paroxysms of atrial fibrillation, bundle-branch blocks and worsening of the kidney function. We suppose that a low level of superoxide anion in neutrocytes play a major role in the development of complications in patients with acute coronary syndrome. An intravenous administration of corvitin was ef­fective in restoring the metabolic activity of neutrocytes.

Keywords: acute coronal syndrome, neutrocytes, quercetinum.


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