Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(2): 19-26

Correction of lipid peroxidation and antioxidant system disorders by bioflavonoids during modeling of cholesterol atherosclerosis in rabbits

Shysh A, Pashevin DO, Dosenko VIe, Moĭbenko OO

    O.O.Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine


We have studied the influence of bioflavonoids (quercetin, corvitin) on lipid peroxidation and antioxidant enzymes in the modeling of cholesterol atherosclerosis in rabbits. It has been shown that simultaneous administration of the quercetin de­rivative corvitin suppressed lipid peroxidation. We showed that under hypercholesterolemia, the concentration of malone dialdehyde in myocardial tissue in rabbits is significantly in­creased, while administration of bioflavonoids decreased the concentration of malone dialdehyde by 38,3 %. Furthermore, corvitin caused activating effects on antioxidant enzymes su-peroxide dismutase and catalase in cardiac tissue. Our data suggest that bioflavonoids are able to suppress lipid peroxidation and prevent the decrease of antioxidant enzymes activity in rabbits with cholesterol-rich diet induced athero­sclerosis.

Keywords: cholesterol atherosclerosis, lipid peroxidation,antioxidant enzymes, bioflavonoids, quercetin.


  1. Zevkov NK, Lankin VZ, Menshikova EB Oxidative stress: Biochemical and pathophysiological aspects. M .: Science. Interperiodica, 2001. 343 p.
  3. Nikitin Yu.P., Panin LE, Voevoda MI, Simonova GI, Dushkin MI, Ragino Yu.I., Nikolaev K.Yu., Ryabikov AN, Denisova D .V., Tikhonov AV, Schwartz E.Sh. Questions of atherogenesis. Novosibirsk, 2005. 372 p.
  5. Kolchin YM, Moibenko OO, Maksyutina NP The influence of soluble form of quercetin on the course of experimental myocardial infarction in rats . Medicines. 1995. 6. P. 50-57.
  7. Koroleuk MA, Ivanova AI, Mayorova IT, Tokarev VE A method for determining the activity of catalase . Lab. business. 1988. N 1. P. 16-19.
  9. Lankin B.3., Tikhaze AK, Belenkov Yu.N. Free-radical processes in diseases of the cardiovascular system . Cardiology. 2000. N 7. P. 48-62.
  11. Lankin VZ, Tikhaze AK, Belenkov Yu.N. Free-radical processes in normal and pathological conditions. M .: Nauka, 2001. 78 p.
  13. Manukhina EB, Lyamina NP, Dolotovskaya PV, Mashina S.Yu., Lyamina SV., Pokidyshev DA, Malyshev I.Yu. The role of nitric oxide and oxygen free radicals in the pathogenesis of hypertension . Cardiology. 2002. N 11. P. 73-84.
  15. Pashevin DO, Dosenko VIe, Byts' IuV, Moĭbenko OO.. Proteasome activity changes in the aorta, heart tissues, and blood leucocytes in modelling of cholesterol atherosclerosis.. Fiziol Zh. 2007. 53, N 6. P. 3-10.
  17. Serkiz YA, Druzhinina NA, Khrienko AP, Pavlenko IO, Shlumukova IF Chemiluminescence of blood under radiation exposure. K .: Sciences. opinion, 1989. 176 p.
  19. Steel ID, Garishvili TG Method of determining malonic dialdehyde using thiobarbituric acid. In the book: Contemporary. Methods in Biochemistry . Ed. Orekhovich VN M .: Medicine, 1977. P. 66-67.
  21. Chevari S., Chaba P., Sekey J. The role of superoxide dismutase in the oxidative processes of a cell and its method of determination in biological materials . Lab. business. 1985. N 11. P. 678-681.
  23. Ford D.A. Alterations in myocardial lipid metabolism during myocardial ischemia and reperfusion . Prog. Lipid Res. 2002. 41. P. 6-26. CrossRef  
  24. Fukasawa R., Kanda A., Hara S. Anti-oxidative effects of rooibos tea extract on autoxidation and thermal oxidation of lipids . J. Oleo Sci. 2009. 58(6). P. 275-283. CrossRef PubMed
  26. Heinecke J.W. Oxidants and antioxidants in the patho­genesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis . J.W. Heinecke Atherosclerosis. 1998. 141. P. 1-15. CrossRef  
  27. Jimhnez R., Lypez-Sepblveda R., Kadmiri M., Romero M., Vera R., S6nchez M., Vargas F., O'Valle F., Zarzuelo A., Duecas M., Santos-Buelga C, Duarte J. Polyphe­nols restore endothelial function in DOCA-salt hyper­tension: role of endothelin-1 and NADPH oxidase . Free Radic. Biol. Med. 2007. 43(3). P. 462-73. CrossRef PubMed
  29. Kamada C, da Silva E.L., Ohnishi-Kameyama M., Moon J.H, Terao J. Attenuation of lipid peroxidation and hyperlipidemia by quercetin glucoside in the aorta of high cholesterol-fed rabbit . Free Radic. Res. 2005. 39, N 2. P. 185-194. CrossRef PubMed
  31. Lisovyy O.O., Dosenko V.E., Nagibin VS., Tumanov-ska L.V, Korol M.O., Surova O.V, Moibenko O.O. Cardioprotective effect of 5-lipoxygenase gene (ALOX5) silencing in ischemia-reperfusion . Acta Biochim. Pol. 2009. 56(4) P.687-694. CrossRef PubMed
  33. Mulvihill E.E., Huff M.W. Antiatherogenic properties of flavonoids: implications for cardiovascular health . Can. J. Cardiol. 2010. 26. P.17A-21A. CrossRef  
  34. Sadik CD., Sies H., Schewe T. Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action .Biochem. Pharmacol. 2003. 65. P.773-781. CrossRef  
  35. Victor V.M., Rocha M., Sol6 E. Oxidative stress, en­dothelial dysfunction and atherosclerosis . Curr. Pharm. Des. 2009. 15(26). P.2988-3002. CrossRef PubMed
  37. de Whalley C, Rankin S., Hoult J., Jessup W., Leake D. S. Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages . Biochem. Pharmacol. 1990 39. P.1743-1750. CrossRef  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2021.