Effects of amixine on electrophoretic mobility of murine T lymphocytes
Dolha OV, Pohoriela NKh, Bohorad-Kobel's'ka OS, Andronati SA, Mahura IS
- O.O. Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kyiv, Ukraine
- D.K. Zabolotny Institute of microbiology and virology National Academy of Sciences of Ukraine, Kyiv, Ukraine
- O.V. Bogatsky Physicî-Chemiñal Institute National Academy of Sciences of Ukraine, Odesa, Ukraine
DOI: https://doi.org/10.15407/fz57.02.014
Abstract
The amixine-induced early changes in the electrophoretic mobility (EPM) of murine splenic T lymphocytes were studied in vitro by the microelectrophoresis technique. It has been found that T lymphocytes treated with amixine have a greater EPM within the first hours of amixine addition than control cells. This change in EPM depends on the concentration of amixine in the medium and the duration of amixine exposure. It was concluded that the amixine-treated cells have a greater net negative surface charge density than control cells. This effect may play an important role in the cell-cell interaction during the immune response.
Keywords:
амиксин, индукторы интерферона,электрофоретическая подвижность, Т-лимфоциты.
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