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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(2): 14-18

Effects of amixine on electrophoretic mobility of murine T lymphocytes

Dolha OV, Pohoriela NKh, Bohorad-Kobel's'ka OS, Andronati SA, Mahura IS

  1. O.O. Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kyiv, Ukraine
  2. D.K. Zabolotny Institute of microbiology and virology National Academy of Sciences of Ukraine, Kyiv, Ukraine
  3. O.V. Bogatsky Physicî-Chemiñal Institute National Academy of Sciences of Ukraine, Odesa, Ukraine


The amixine-induced early changes in the electrophoretic mo­bility (EPM) of murine splenic T lymphocytes were studied in vitro by the microelectrophoresis technique. It has been found that T lymphocytes treated with amixine have a greater EPM within the first hours of amixine addition than control cells. This change in EPM depends on the concentration of amixine in the medium and the duration of amixine exposure. It was concluded that the amixine-treated cells have a greater net negative surface charge density than control cells. This effect may play an important role in the cell-cell interaction during the immune response.

Keywords: амиксин, индукторы интерферона,электрофоретическая подвижность, Т-лимфоциты.


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