Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(1): 94-105


Influence of chronic emotional stress on the behaviour in "open field" test of rats with different level of motor activity

Shever'ova VM

    Research Institute of Biology, V.N. Karazin Kharkov National University, Ukraine
DOI: https://doi.org/10.15407/fz57.01.094

Abstract

Experiments were carried out on 41 Wistar mail rats with body weight of 180 - 200 g. It was shown that in ‘open field’ the rats differed in the level of motional activity. Indepen­dently from level of locomotion investigated groups of rats were dissimilar at the criterions for “emotionality” and latent period of go out from the centr of “field”. Prolonged neurogen stress rendered various (modulating) influence on the behaviour of the rats in‘open field’ that was depended from their start level of activity. In the lowactive rats stress in the main acti­vated the motional and searching components of behaviour against a background of some decrease of the acts of defeca­tion. In the meanactive rats stress increased the freguency of rearing and strengthened excretion function and in the highactive of rats stress reduced the guantity of horizontal moving and lowered the thresholds of reactions of rats on the skin electri­cal stimulation, facilitated increase in these of rats the level of “emotionality”. Direction of changes of the time go out from the centr of “field” in each tested group basically depended by its start indexes and on peak of stress action had reverse de­pendence. It is supposed that changes of behaviour of rats in the “open field” under corresponding intensity of stress may be coused as by neuroendokrine changes as by stress damage of brain structures.

Keywords: “open field” test, motional activity, chronicalemotional stress.

References

  1. Ayrapetyants MG, Honicheva IM, Mehedova A.Ya. Reactions to moderate functional stress in rats with individual behavioral features . Journal. higher nerve. activities. 1980. 30, no. 5. P. 994-1062.
  2.  
  3. Arushanian EB, Beyer EV The place of the hippocampus in the biorhythmic organization of behavior . Uspekhi fiziol. Sciences. 2001. 32, No. 1. P. 79-95.
  4.  
  5. Beneshova O. Genetically conditioned behavioral variability in rats and its biochemical correlates . Journal. higher nerve. activities. 1978. 28, no. 2, pp. 314-321.
  6.  
  7. Bondarenko NA, Devyatkina TA, Voskresensky ON Influence of chronic emotional stress on the state of lipid peroxidation in tissues and blood of emotional and non-emotional rats . Bul. experiment. biology and medicine. 1995. 100, N 7. pp. 12-14.
  8.  
  9. Buresh Y., Bureshova O., Houston P. Methods and basic experiments in the study of the brain and behavior. M.: Higher. shk. 1991. 299 p.
  10.  
  11. Gershtein LM, Kamysheva AS, Chebotareva TL Morphochemical characteristics of the brain of Wistar rats differing in locomotor activity in an open field . Journal. higher nerve. activities. 1991. 41, no. 2, pp. 300-304.
  12.  
  13. Gasanov GG, Ismailova H.Yu., Gromova EA The role of catecholaminergic innervation of the frontal region of the neocortex in the regulation of the behavior of rats with different resistance to acoustic stress . Journal. higher nerve. activities. 1995. 45, no. 5. P. 1007-1013.
  14.  
  15. Gulyaeva NV, Stepanichev M.Yu. Biochemical correlates of individually typological features of rat behavior . Ibid. 1997, no. 2, pp. 329 338.
  16.  
  17. Kolpakov VV, Bespalova TV, Bragina AV Concept of typological variability of physiological personality. Message 1. Intra-population diversity of habitual motor activity of a person and its typical assessment . Human physiology. 2008. 34, No. 4. P. 121-132. CrossRef  
  18. Koplik EV, Salieva P.M., Gorbunova AV An open-field test as a predictive criterion for emotional distress in Wistar rats . Journal. higher nerve. activities. 1995. 45, No. 4. C. 775-781.
  19.  
  20. Kulagin DA, Bolondinsky VK Neurochemical aspects of emotional reactivity and motor activity of rats in a new environment . Uspekhi fiziol. Sciences. 1986. 17, No. 1. P. 92-108.
  21.  
  22. Kulikov VP Individual peculiarities of spontaneous locomotor activity and adaptive behavior of rats . Journal. higher nerve. activities. 1990. 40, no. 1, pp. 85-92.
  23.  
  24. Lepekhina LM The effect of reserpine on rat grooming parameters . Bul. experiment. biology and medicine. 1993. 115, No. 1. P. 10-11. CrossRef  
  25. Livanova LM, Airapetetyants MG, Germanova EL Long-term effect of a single acute hypoxia on the behavior of rats with different typological features . Journal. higher nerve. activities. 1993. 43, no. 1. P. 157-164.
  26.  
  27. Lushnikova IV. [Morphological plasticity of hippocampal CA1 neurons in vitro after short-term anoxia. hypoglycemia followed by reoxygenation]. . Fiziol Zh. 2009. 55, No. 3. P. 109-117.
  28.  
  29. Novikov VE, Arbaeva MV, Parfenov EA The effect of antihypoxant Q226 on the behavior of mice in the "open field" . Psychopharmacology and Biol. narcology. 2005. 5, no. 3. P. 979-983.
  30.  
  31. Petrov VI, Grigoriev PA, Afimenko VL Prediction of the resistance of rats to emotional stress . Journal. higher nerve. activities. 1996. 46, no. 6. C. 1119-1121.
  32.  
  33. Podkletnova IM, Alho H.E. Damage to the catecholaminergic system causes a slowdown in the formation of early behavioral responses in rats. higher nerve. activities. 1995. 45, no. 5. C. 1023-1027.
  34.  
  35. Pshennikova MG, Bondarenko NA, Shimkovich MV Differences in behavior and resistance to gastric ulcer under stress in rats of the August and Wistar lines adapted and not adapted to hypoxia . Bul. experiment. biology and medicine. 1999. 128, N 12. P. 638-641. CrossRef  
  36. Sahach VF, Baziliuk OV, Oleshko MM, Kotsiuruba AV, Appenzeller O. [The nitrous oxide system under conditions of chronic cerebral dopamine deficiency and hypoxia]. . Fiziol Zh. 1999. 45, N 1-2. P. 16-25.
  37.  
  38. Sarkisova K.Yu., Kolomeytseva I.A. Individual differences in reactions to acute stress related to type of behavior. Resistance (predisposition) to behavioral and sleep disorders . Bul. experiment. biology and medicine. 1993. 116, N 8. P. 130-132.
  39.  
  40. Saulskaya NB The effect of neuroticism on the metabolism of dopamine in rat brain with different activity in the open field test . Physiol. . them. P.M. Sechenov. 1989. 75, No. 3. P. 397-400.
  41.  
  42. Semagin VN, Zuhar AV, Kulikov MA Type of nervous system, stress resistance and reproductive function. M .: Nauka, 1988. 133 p.
  43.  
  44. Semenova TP Age-specific features of the adaptive behavior of hippocamped rats. In the book: Mechanisms of adaptive behavior. L .: Nauka, 1986. C. 54-57.
  45.  
  46. Simonov PV Motivated brain. M .: Science, 1987. 266 p.
  47.  
  48. Strekalova TV Changing the defensive response in rats under the influence of a peptide causing delta sleep . Journal. higher nerve. activities. 1995. 45, no. 3. P. 593-595.
  49.  
  50. Sudakov KV Individuality of emotional stress . General questions. neurology and psychiatry. 2005. 105, N 2. WITH. 4-12.
  51.  
  52. Shapovalova KB, Gorbachevskaya AI, Saulskaya NB Structural organization and neurochemical mechanisms of involvement of the adjoining nucleus in the interaction of the limbic and motor systems and in the regulation of motor behavior . Journal. higher nerve. activities. 1992. 42, no. 2. P. 226-276.
  53.  
  54. Shevereva VM Features of formation and reversibility of emotional disturbances in rats in neurogenic stress . Neurophysiology . Neurophysiology. 2003. 35, No. 2. P. 147-158.
  55.  
  56. Sheveryova V.M. Neurophysiological effects (3-block catator of obsidian in conditions of modeling emotional stress . Physiological journal 1997. 43. N 1-2. P. 31-39.
  57.  
  58. Shiryaeva NV, Vaido AI, Lopatin NG The effect of neuroticism after a long time after its termination on the behavior of rats differing in the excitability of the nervous system . Journal. higher nerve. activities. 1996. 46, no. 1. P. 157-162.
  59.  
  60. Berman R.M, Narasimhan M., Miller H.L, Anand A. Transient depressive relapse induced by catecholamine depletion: potential phenotypic vulnerability marker? . Arch. Gen. Psychiatry. 1999. 56, N 5. P. 395-440. CrossRef PubMed
  61.  
  62. Buisman-Pijlman Femke T.A., Herremans A.H.J., Van De Kieft J., Kruse C.G.,Van Ree J.M. Behavioural changes after different stress paradigms: Prepulse in­hibition increased after physical but not emotional stress . Europ. Neuropsychopharmacol. 2003. 13, N 5. P. 369-380. CrossRef  
  63. Chrousos G.P., Gold P.W. The concepts of stress sys­tem disordes: overview of behavioral and physical homeostasis . J. Amer. Med. Asoc. 1992. 267. P. 1244-1252. CrossRef PubMed
  64.  
  65. Craig W. Berridge. Noradrenergic modulation of arousal . Brain Res. Rev. 2008. 58, N 1. P. 1-17. CrossRef PubMed PubMedCentral
  66.  
  67. Huanhuan Li, Wenjuan Lin, Junfa Li. The effects of acute emotional stressor on behavior and phosphory­lation levels of neurogranin in rats . Acta Psychol. Sinica. 2006. 38, N 4. P. 576-582.
  68.  
  69. Sapolsky R. Glucocorticoids, hippocampal damage and glutamatergic synapse . Prog. Brain Res. 1999. 86. P. 13-23. CrossRef  
  70. Weyersa Peter, Bowerd David B., Vogelb Wolfgang H. Relationships of plasma catecholamines to open-field behavior after inescapable shock . Neuropsychobiol. 1989. 22, N 2. P. 108-116. CrossRef PubMed

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2020.