Analgesia evoked by combined effect of corvitin and low-intensity microwaves on acupuncture points in mice of different genetic strains with somatic pain
Hura OV, Bahats'ka OV, Lymans'kyĭ IuP
Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz57.01.082
Abstract
The level of analgesia has been investigated in mice of two genotypes C57BL/6J Bl/6j and CBA/CaLac with the somatic pain caused by the formalin test after irradiation of acupuncture point E-36 by microwaves of low intensity (30-300 GHz, density of a stream of capacity of 3-10-9 Вт/cm2) on a background entered corvitin (20 mg / kg). It is shown, that the action of these two factors causes significant analgesia with different levels: 43 % in C57BL/6J Bl/6j mice and 33 % in CBA/CaLac mice. The intensity of analgesia after action of microwaves and corvitin exceeds the level attained during separate use of these factors.
Keywords:
acupuncture point, microwaves, corvitin.
References
- Avgustinovich DF, Lipina GV, Alekseenko OV, Amstislavskaya TG, Kudryavtseva NN Features of functional activity of brain serotonergic system in manifestation of natural and pathological anxiety in mice: influence of genotype . Journal. higher nerve. activities. 1998. 48, N 2. p. 331-341.
- Bahats'ka OV, Hura OV. Evaluation of analgesia evoked by microwaves of low intensity in the point of acupuncture in mice with different genotypes.. Fiziol Zh. 2004. 50. N 2. P.80-85.
- Bogatskaya EV, Gura EV Analgesia caused by microwave irradiation of the acupuncture point in visceral pain in mice: the role of the serotonin-ergic brain system . Neurophysiology . Neurophysiology. 2005. 37, N 3. p. 250-257.
CrossRef
- Bogatskaya EV, Gura EV, Limansky Yu.P. Analgesia caused by microwave irradiation of acupuncture point in visceral pain in mice: the role of the brain opioid system . Neurophysiology. 2008. 40, N 5. 6. p. 426-437.
CrossRef
- Gura EV, Bogatskaya EV, Limansky Yu.P. Participation of the serotonergic system in analgesia caused by the action of low-intensity microwaves on the acupuncture point of pain . Neurophysiology. 2002. 34, N 4. p. 303-308.
- Gura EV, Bogatskaya EV, Limansky Yu.P. Participation of the serotonergic system in the provision of analgesia caused by microwave irradiation of an acupuncture point . Arch. wedge. and experiment. medicine. 2001. 10, N 2. P.145.
- Gura OV, Bogatskaya OV Participation of the serotonergic system of the brain in pain reactions caused by the introduction of formalin in mice . Fiziol Zh. 2002. 48, N 2. p.22.
- Gonchar OM, Gura OV Pharmacological and microwave induced radiation suppression of somatic pain in formalin in mice . Neurophysiology . Neurophysiology. 2006. 38, N 1. P. 46-51.
- Lymans'kyĭ IuP, Bahats'ka OV, Hura OV, Nesin OM, Sushko BS, Tamarova ZA. Influence of korvityn on somatic pain in mice of different genotypes.. Fiziol Zh. 2008. 54, N 4. P.37-43.
- Limansky Yu.P., Tamarova SA, Bidkov EG, Kolbun MD Suppression of nociceptive responses in mice under the influence of low-intensity microwave irradiation of acupuncture points . Neurophysiology . Neurophysiology. 1998. 31. N 4. p. 318.
CrossRef
- Moibenko AA, Dosenko VE, Parkhomenko AN Endogenous mechanisms of cardioprotection as a basis for pathogenetic therapy of heart disease. K .: Sciences. opinion, 2008. 520 p.
- Nesin EN, Gura EV Analgesia induced by the combined use of tramadol and microwave irradiation in somatic pain in mice . Neurophysiology . Neurophysiology. 2006. 38, N 4. p. 314-320.
CrossRef
- Nesin OM, Gura OV, Kolbun M.D. Combined use of pharmacological analgesics and microwave irradiation of acupuncture point for suppression of visceral pain in mice: role of opioid and serotonergic brain systems . Neurophysiology . Neurophysiology. 2007. 39, N 6. p. 470-478.
CrossRef
- Chuyan EN, Dzheldubayeva ER Mechanisms of antinociceptive action of low-intensity millimeter radiation. Simferopol: DYIPP, 2006. 440 p.
- Anjaeyulu M., Chopra K. Quercetin, a biophlavanoid, attenuates thermal hyperalgesia in a mouse model of diabetic neuropatic pain. Prog. Neuropsychopharmacol. Biol. Psychiat. 2003 27. P.1001-1005.
CrossRef
- Bagatskaya E.V. Involvement of the serotoninergic cerebral system in microwave-induced analgesia in mice of different genotypes. Neirofiziologiya . Neurophysiology. 2006. 38, N 5. 6. P.424-426.
CrossRef
- Bagatskaya E.V., Gura E.V., Limansky Yu.P. Connection between analgesia caused by microwave irradiation of acupuncture point and brain serotoninergic system. In: Abstract of Communications 10th World Congress of Pain San Diego, August 17-19. 2002. P.263.
- Bagatskaya E.V., Gura E.V., Limansky Yu.P.,Kolbun N.D. Participation of serotoninergic system in analgesia evoked by action of the low-intensive microwaves on acupuncture point. In: Abstract of European Conference of Pain. Poland. Warshawa, 2001. P.151.
- Dubuisson D., Dennis S.G. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine and brain stem stimulation in rats and cat. . Pain. 1977. 4 P.161-174.
CrossRef
- Gadotti V.M., Schmeling L.O., Machado C, Liz F.H., Filho V.C., Meyere-Silva C, Santos A.R. Antinociceptive action of the extract and the flavonoid quercetin isolated from Bauhinia microstachya leavels . J. Pharm. Pharmacol. 2005. 57 P.1345-1351.
CrossRef
PubMed
- Haskaar S., Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain . Pain. 1987. 30. P.103-104.
CrossRef
- Kaur R., Singh D., Chopra K. Partisipation of alpha 2 receptors in the antinociceptive activity of quercetin . . J. Med. Food. 2005. 8. P.529-532.
CrossRef
PubMed
- Mogil J.S., Rest B., Sadowski D., Belknap J.K. Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay . J. Pharmacol. Exp. Therap. 1996. 27. P.532-544.
- Mogil J.S., Richards S.P., OToole L.A., Helms M.L., Mitchell S.R.,Belknap J.K. Genetic sensitivity to hotplate nociception in DBA. 2J and C57BL. 6J BL. 6J inbred mouse strains: Possible sex-specific mediation by delta2-opioid receptors . Pain. 1997. 70. P.267-277.
CrossRef
- Usichenko T.I., Ivashkivsky O.I., Gizhko V.V. Treatment of rheumatoid arthritis with electromagnetic millimeter waves applied to acupuncture points a randomized double blind clinical study. Acupunct. Electrother. Res. 2003. 28, N 1-2. P.11-18.
CrossRef
PubMed
- Usichenko T.I., Herget H.F. Treatment of chronic pain with millimetre wave therapy (MWT) in patients with diffuse connective tissue diseases: a pilot case series study. Eur. J. Pain. 2003. 7, N 3. P.289-294.
CrossRef
|