Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(1): 72-81


Disorders of uric acid metabolism in ratswith fructose- induced experimental insulin resistance syndrome

A.A.shuprovich, N.M.gurina, O.V.korpacheva-zinych

    ДУ «Ін-т ендокринології та обміну речовинім. В.П. Комісаренка НАМН України», КиївE-mail: admin @ iem. kiev. ua


Abstract

Consumption of dietary fructose has been recently suggested to be one of the environmental factors contributing to develop­ment of obesity and accompanying abnormalities of the insulin resistance syndrome (IRS). IRS was induced in rats by adding 10% fructose to drinking water. Within 8 wk insulin resistance, carbohydrate metabolism disorder, weight gain, hyper-trigyceridemia and hyperuricemia were developed. The signs of IRS were more pronounced in male than in female rats. An increase of uric acid (UA) daily excretion was revealed only in males, suggesting a hyperproductoin of UA. There was not significant disorder of kidney filtration, although an increase of UA clearance was revealed due to enhanced kidney urate reabsorbtion which may be connected to the hypouricosuric action of insulin but not the testosterone level changes. It was first revealed an increased activity of enzymes catalyzing early stages of purine catabolism (5'-nucleotidase and adeno-sindesaminase) in liver homogenate. Activity of enzyme of purine reutilisatoin (hypoxantin-guanine-phosphoribosil trans­ferase) was found increased that may have a compensatory significance under conditions of increased purine degradation.

Keywords: uric acid, insulin resistance syndrome, fructosediet, rats, purine degradation enzymes.

References

  1. Доклінічні дослідження лікарських засобів (мето­дичні рекомендації) / За ред. О.В. Стефанова. - К.: Авіцена. - 2001. - 528 c.
  2. Мадянов И.В., Балаболкин М.И., Марков Д.С., Мар­кова Т.Н. Основные причины гиперурикемии при сахарном диабете // Терап. архив. - 2000, №2. - С. 58–60.
  3. Мухин Н.А., Балкаров И.М, Бритов А.Н. Тубуло-интерстициальный нефрит и артериальная гипер­тония - клиническое и популяционное значение // Там же. - 1997. - 69, №7. -С. 5–10.
  4. Руководство по клинической лабораторной диаг­ностике / Под ред. Меньшикова В.В. - М.: Меди­цина, 1982. - 576 c.
  5. Магарламов А.Г. Аспарагиназная и аденозин-дезаминазная активность в ткани печени крыс при различных условиях белкового и безбелкового питания // Укр. биохим. журн. - 1980. - 52, №4. -С. 446-452.
  6. Bantle J.P., Raatz S.K., Thomas W., Georgopoulos A. Effects of dietary fructose on plasma lipids in healthy subjects // Amer. J. Clin. Nutr. - 2000. - 72. - P. 1128-1134.
  7. Dai S., McNeill J.H. Fructose-induced hypertension in rats is concentration- and duration-dependent // J. Pharmacol. Toxicol. Methods. - 1995.- 33. - P. 101-107.
  8. Dennison B.A., Rockwell H.L., Baker S.L. Excess fruit juice consumption by preschool-aged children is asso­ciated with short stature and obesity // Pediatrics. -1997. – 99. – P. 15-22.
  9. 9. Facchini F., Chen Y.D., Hollenbeck C.B., Reaven G.M. Relationship between resistance to insulin-mediated glu­cose uptake, urinary uric acid clearance, and plasma uric acid concentration // JAMA. - 1991. - 266. - P. 3008-3011.
  10. 10. Galipeau D., Verma S., McNeill J. Female rats are pro­tected against fructose-induced changes in metabolism and blood pressure // Amer. J. Physiol. Heart. Circ. Physiol. - 2002. - 283, №6. - P. H2478-H2484.
  11. Hwang I.S., Ho H., Hoffman B.B., Reaven G.M. Fruc­tose-induced insulin resistance and hypertension in rats // Hypertension. - 1987. - 10. - P. 512-516.
  12. Ludwig D.S., Peterson K.E., Gortmaker S.L. Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis. - Lancet. - 2001. - 357. - P. 505-508.
  13. Masuo K., Kawaguchi H., Mikami H., Ogihara T., Tuck M.L. Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation // Hypertension. - 2003. -42. - P. 474-480.
  14. Michel R.M., Hawthorne S. N. The site of diphos-phoinozitole synthesis in rat liver // Biochem. Biophys. Res. Commun. - 1965. - 21, № 4. - P. 333-338.
  15. Nakagawa T., Hanbo Hu, Zharikov S., Tuttle K.R., Short R.A., Glushakova O., Xiaosen Ouyang, Feig D.I., Block E. R., Herrera-Acosta J., Patel J. M., Johnson R. J. A causal role for uric acid in fructose-induced metabolic syndrome // Amer. J.Physiol. Renal. Physiol. -2006. - 290. - P. F625-F631.
  16. Pizzichini M., Leoncini R., Vannoni D. The influence of testosterone on purine nucleotide metabolism in rat liver // Life Sci. - 1995. - 57. - P. 2127-2135.
  17. Sanchez-Lozada L., Tapia E., Jimnez A. Fructose-in­duced metabolic syndrome is associated with glom­erular hypertension and renal microvascular damage in rats // Amer. J. Physiol. Renal Physiol. - 2006.- 292. -P. F423-F429.
  18. Hare M.B., Manson J.E., Ludwig D.S. Sugar-sweet­ened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women // JAMA. -2004. - 292. - P. 927-934.
  19. 19. Sekine T., Miyazaki H., Endou H. Molecular physiol­ogy of renal organic anion transporters // Amer. J. Physiol. Renal Physiol. - 2006. - 290. - P. F251-F261.
  20. 20. Song D., Arikawa E., Galipeau D., Battell M., McNeill J.H. Androgens are necessary for the development of fructose-induced hypertension // Hypertension. -2004. - 43. - P. 667-672.
  21. Stirpe F., Della Corte E., Bonetti E. Fructose-induced hyperuricaemia // Lancet. - 1970. -№2. - P. 1310-1311.
  22. Tsunoda S., Kamide K., Minami J., Kawano Y. De­creases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent / / Amer. J. Hypertens. - 2002. - 15. - P. 697-701.
  23. Vasudevan H., Xiang H., McNeill J.H. Differential regulation of insulin resistance and hypertension by sex hormones in fructose-fed male rats // Amer. J. Physiol. Heart Circ. Physiol. - 2005. - 289. -P. H1335-H1342.
  24. Vizzotto L., Vartemati M., Marinello E., Leoncini R., Pagani R., Pizzichini M. Effect of testosterone on purine metabolism and morphometric parameters in the rat liver / / Mol. Cell. Endocrinol. - 1996. - 119. - P. 123-127.
  25. Xiang G., Lu Qi, Qiao N. Intake of added sugar and sugar-sweetened drink and serum uric acid concent­ration in US men and women // Hypertension. - 2007. -50. - P. 306-316.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.