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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(1): 66-71


Correction of negative influence of long-term hypergastrinemia on gastric acid secretion

Tsyriuk OI

    Kyiv National Taras Shevchenko University, Ukraine
DOI: https://doi.org/10.15407/fz57.01.066

Abstract

We investigated the influence of long-term diminishing of gas­tric acid secretion in rats by H+-K+-ATPase omeprasole on the gastrin blood level and the basal gastric acid secretion. We performed an experimental analysis of possible prophylactic drugs of structural and functional changes in gastric mucosa evoked by hypergastrinemia. It was shown that following 28 days of omeprazole injections the blood gastrin level and the output of basal acid secretion increased by 189,3% and173,9-283,7%, respectively. It was concluded that an augmentation of the output of basal acid secretion results from the develop­ment of parietal cells hyperplasia evoked by trophic action of gastrin. We also show here that agonists of nuclear peroxisome proliferator activator receptors pioglytasone and melanin ef­fectively prevent the changes in gastric acid secretion as an index of morphological changes.

Keywords: gastric acid secretion, omeprasole, gastrin, peroxi-some proliferators activator receptors gamma

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