Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(1): 66-71

Correction of negative influence of long-term hypergastrinemia on gastric acid secretion

Tsyriuk OI

    Kyiv National Taras Shevchenko University, Ukraine


We investigated the influence of long-term diminishing of gas­tric acid secretion in rats by H+-K+-ATPase omeprasole on the gastrin blood level and the basal gastric acid secretion. We performed an experimental analysis of possible prophylactic drugs of structural and functional changes in gastric mucosa evoked by hypergastrinemia. It was shown that following 28 days of omeprazole injections the blood gastrin level and the output of basal acid secretion increased by 189,3% and173,9-283,7%, respectively. It was concluded that an augmentation of the output of basal acid secretion results from the develop­ment of parietal cells hyperplasia evoked by trophic action of gastrin. We also show here that agonists of nuclear peroxisome proliferator activator receptors pioglytasone and melanin ef­fectively prevent the changes in gastric acid secretion as an index of morphological changes.

Keywords: gastric acid secretion, omeprasole, gastrin, peroxi-some proliferators activator receptors gamma


  1. Beregova T.V., Tsiryuk O.I., Voronina O.K., Kukharsky V.M., Ovcharik T.V. Structural and functional changes in the stomach caused by prolonged hypergastrinemia, and the search for methods of their prophylaxis In the book: Abstracts. IY International. Conf. "Psychophysiological and Visceral Functions in Norm and Pathology", dedicated to the 90th birthday of P.G. God forbid. K, 2008. P. 43-44.
  3. Vasilyev YV Omeprazole in the treatment of gastroesophageal reflux disease and peptic ulcer of the stomach and duodenum . Rus. honey. . 2007. 15, N 4. P.233-236.
  5. Glantz S. Biomedical statistics. M .: Practice, 1998. 459p.
  7. Groysman SD, Gubkin VA, Beregovaya TV Semi-automatic electro-titrometer unit for gastric juice titration . Lab. business. 1988. 9. p. 66-67.
  9. Gurlenko T.M., Voronina O.K., Ovcharik T.V., Beregova T.V. The effect of blockade of CCS . gastrin receptors on the transport function of the colon in conditions of prolonged hypergastrinemia . Experim. and a clip. physiology and biochemistry. 2007. 36, N 1. pp. 16-21.
  11. Ivashkin VT, Sheptulin AA Prospects of proton pump blockers in gastroenterology . Diseases of the digestive system. 2001. 3, N 1. p. 78-84.
  13. Pokrovsky VI Biomedical ethics. M .: Medicine, 1997. 224 p.
  15. Rud M.V. Combined use of proton pump inhibitors and histamine blockers of histamine receptors in the treatment of gastric ulcer . Experiment. and a wedge. gastroenterology. 2003. N 1. P.105.
  17. Tsiryuk OI, Beregova TV The effect of omeprazole-induced hypergastrinemia on basal gastric secretion in rats . Vis. problems of biology and medicine. 2007. N 3. pp. 38-43.
  19. Chizhanskaya NV, Beregova TV, Tsiryuk OI On the participation of nitric oxide in the cytoprotective action of melanin on the gastric mucosa . Visn. problems of biology and medicine. 2005. N 3. p. 56-59.
  21. Bamba T., Kosugi S., Kanda T., Tsubono T., Sakai Y, Musha N. Multiple carcinoids in the duodenum, pan­creas and stomach accompanied with type A gastritis: a case report . Gastroenterology. 2007. 13, N 15. P 2247-2249.
  22. CrossRef PubMed PubMedCentral  
  23. Behar J. Clinical aspects of gallbladder motor function and dysfunction . Curr. Gastroenterol. Rep. 1999. 1,N 2. P.91-94. CrossRef PubMed
  25. Castellote J., Porta F., Badal J.M., Sant F., Valdes V., Libori R. Chronic atrophic gastritis, hypergastinemia and gastric carcinoid tumor. Rev. Esp. Enferm. Dig. 1997. 89, N 6. P. 485-487.
  27. Cattan D., Roucayrol A., Launay J., Callebert J. Se­rum gastrin and agrophil cell hyperplasia relationships in fundic atrophic gastritis. In book: Hakanson, R., Sundler F. The stomach as an endocrine organ. Amsterdam-London-New York-Tokio: Elsevier. 1991. P.425-448.
  29. Frucht, H., Maton P. N., Jensen R. T. Use of omeprazole in patients with the Zollinger-Ellison syn­drome . Dig. Dis. Sci. 1991. 36. P. 394-404. CrossRef PubMed
  31. Ghosh M.N., Shild H.O. Continuous recording of acid gastric secretion in the rat . Br. J. Pharmacol. 1958. P. 13-14. CrossRef PubMed PubMedCentral
  33. Havu N. Enterochromaffin-like cell carcinoids of gas­tric mucosa in rats after life-long inhibition of gastric secretion . Digestion. 1986. 35, N 1. P. 42-55. CrossRef PubMed
  35. Jensen R.T. Consequences of long-term proton pump blockade: insights from studies of patients with gastrinomas . Basic Clin.Pharmacol.Toxicol. 2006. 98,N 1. P.419. CrossRef PubMed
  37. Jonson L.R., Guhrie P.D. Proglumide inhibition of trophic action of pentagastrin . Amer. Phisiol. Soci­ety. 1984. G. 62-66. CrossRef PubMed
  39. Konturek P. C, Brzozowski T., Kania J. Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat . Eur. J. Pharmacol. 2003. 472, N 3. P.213-220. CrossRef  
  40. McColl K. E. Helicobacter pylori infection and long term proton pump inhibitor therapy . Gut. 2004. 53. P. 57. CrossRef PubMed PubMedCentral
  42. Plonska P., Grabacka M. Melanin synthesis in micro­organisms biotechnological and medical aspects . Acta Biochim. Pol. 2006. 53, N 3. P. 429-443.
  44. Selway S.A. Potential hazards of long-term acid sup­pression . Scand. J.Gastroenterol. 1990. 178. P.85-92. CrossRef PubMed
  46. Solcia E., Capella C, Fiocca R, Rindi G. Gastric argyrophil carcinoidosis in patients with Zollinger-Ellison syndrome due to type 1 multiple endocrine neoplasia. A newly recognized association . Amer. J. Surg. Pathol. 1990. 14. P. 503-513. CrossRef PubMed
  48. Solcia E., Rindi G., LaRosa S., Capella C. Morpholo­gical, molecular, and prognostic aspects of gastric en­docrine tumors . Microsc. Res. Tech. 2000. 48. P. 339-348. CrossRef  
  49. Wormsley K.G. Is chronic long-term inhibition of gas­tric secretion really dangerous? . Scand. J.Gastro­enterol. 1988. 146. P.166-174. CrossRef PubMed
  51. Zheng Q., Chen Y The effects of cholecystojejuno-stomy and biliary drainage on biliary motor . J. Huazhong Univ. Sci. Technolog. Med. Sci. 2002. 22, N 2. P.144-147. CrossRef PubMed

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.