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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(1): 55-65

Effect of medical form of flocalin on the course of myocardial reperfusion injury

Strutyns'kyĭ RB, Rovenets' RA, Neshcheret OP, Tumanovs'ka LV, Boĭchuk TM, Dzhuran BV, Moĭbenko OO

    Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz57.01.055


Abstract

In experiments on anaesthetized dogs with modeling of experi­mental ischemia (90min) and reperfusion (180min), the car­dioprotective influence of the pharmacological precondition­ing caused by intragastric (with a help of catheter) introduc­tion of medicinal form (tablets) of new fluorine-containing opener of ATP-sensitive potassium channels flocalin was shown. Flocalin was introduced in a dose 2,2mg/kg, which in the conditions of physiological norm has a minimum influence on the parameters of cardiohemodynamic. The conducted research allowed to define the changes of these parameters during development of antiischemic protective effect of phar­macological preconditioning, caused by the medicinal form of flocalin, and describes basic cardioprotective mechanisms, related to the changes of cardiohemodynamic in the dynamics of ischemia-reperfusion of myocardium. In our opinion, to positive influences of flocalin, which are possibly related to cardioprotective action, it is possible to add the prevention of an increase of general peripheral resistance, resistance of coronal vessels of heart, and relative preservation of myocardium contractility in the period of reperfusion. Also these positive effects can be explained by moderate decrease of blood pres­sure that decreases the loading on the damaged heart and al­lows to preserve cardiac emission in the first period of is­chemia. One of the major indexes of development of protec­tive mechanism of pharmacological preconditioning caused by preischemic introduction of medicinal form of flocalin is the diminishing of infarct size of myocardium in experiments with ischemia-reperfusion of myocardium on 42,53% ± 2,91% ver­sus control experiments.

Keywords: KATP channels, floсalin, medicinal form, ischemia-reperfusion, сardiohemodynamic, infarct of myocardium

Full text: (PDF, in Ukrainian)

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