Characteristics of arginine metabolism and nitric oxide synthesis in young people during adaptation to physical load in training and competition periods
Bohdanovs'ka NV, Kotsiuruba AV, Malikov MV
- Zaporozhye State University, Ukraine
- O.V. Palladin Institute of Biochemistry, National Akademy of Sciences of Ukraine, Kyiv, Ukraine
A survey of 29 trained and untrained youths in the age of 18-20 years was carried out. It is shown that the optimal level of adaptation of the body to prolonged and intensive physical activity is provided by multi-dominance nonoxidizing arginase metabolism and its oxidative metabolism by constitutively calcium dependent NO-synthase (eNOS and nNOS). Nonoxidizing arginase metabolism results in formation of several important low-molecular bioregulators and antioxidants (urea, polyamines, GABA). Significant reduction of functionality of the trained body at the end of the competitive period and consequently disadaptation correlates with Ca2+ -independent NO synthesis which does not compensate the organism needs in NO.
nitric oxide, arginine, physical stress, adaptation,youths.
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