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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(1): 45-54

Characteristics of arginine metabolism and nitric oxide synthesis in young people during adaptation to physical load in training and competition periods

Bohdanovs'ka NV, Kotsiuruba AV, Malikov MV

  1. Zaporozhye State University, Ukraine
  2. O.V. Palladin Institute of Biochemistry, National Akademy of Sciences of Ukraine, Kyiv, Ukraine


A survey of 29 trained and untrained youths in the age of 18-20 years was carried out. It is shown that the optimal level of adaptation of the body to prolonged and intensive physical activity is provided by multi-dominance nonoxidizing arginase metabolism and its oxidative metabolism by constitutively calcium dependent NO-synthase (eNOS and nNOS). Nonoxidizing arginase metabolism results in formation of sev­eral important low-molecular bioregulators and antioxidants (urea, polyamines, GABA). Significant reduction of function­ality of the trained body at the end of the competitive period and consequently disadaptation correlates with Ca2+ -inde­pendent NO synthesis which does not compensate the organism needs in NO.

Keywords: nitric oxide, arginine, physical stress, adaptation,youths.


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