Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(1): 21-28

Mechanisms of contractile action of acetylcholine on hepatic veins

Ianchuk PI, Prykhod'ko TP, Pasichnichenko OM, Tieriekhov AA, Tsybenko VO

    Taras Shevchenko National University, Kyiv, Ukraine


In acute experiments on anesthetized rats, acetylcholine (Ach) constricts hepatic venous vessels, causing blood mobilization from the liver, and dilates the sphincters of hepatic veins at the exit from this organ, contributing to the intensification of the outflow of blood deposited in the liver. Vasoconstrictor reactions of capacitive vessels of the liver to Ach are realized through M-cholinoreceptors on endotheliocytes with further involvement of messenger, possibly noradrenaline, which ac­tivates a-adrenoreceptors on smooth muscle cells (SMC) of capasitive vessels. Dilation of Hv sphincters is carried out due to Ach-induced release of messenger in the vessel wall, prob­ably adrenaline, which in turn activates b-adrenoreceptors on SMC of the Hv. It is possible, that in such reaction partially involved NO.

Keywords: acetylcholine, hepatic veins, contractile reactions,M-cholinoreceptors, ?- and ?-adrenoreceptors.


  1. Tsybenko VA, Yanchuk PI, Pasichnichenko OM, Komarenko VI Investigation of the vasoconstrictor effect of acetylcholine in venous vessels of the liver . Bul. experiment. biology and medicine. 2006. 143, N 3. P.258-261.
  3. Tsybenko VA, Ianchuk PI, Simonenko PN. [Use of impedance plethysmography for studying the liver depositing function in an acute experiment]. . Fiziol Zh. 1984 Nov-Dec;30(6):756-758.
  5. Yanchuk PI, Dubilei TA, Tsibenko VA Effect of catecholamines on blood circulation in the liver . Biol. science. 1990. N 10. P.97-104.
  7. Ianchuk PI, Pasichnichenko OM, Komarenko VI, Prykhod'ko TP, Tsybenko VO. Elucidation of the mechanisms of acetylcholine constrictor action on the portal vein and its intrahepatic branches.. Fiziol Zh. 2006;52(5):28-33.
  9. Aharinejad S., Nourani M., Egerbasher E.K., Larson A., Miksovsky P.B., Firbas R.S., McCuskey S.C., Marcs Jr. Sphincters of canine hepatic sublobular veins respond to endothelin-1 and 3 . J. Anatomy and Embryol. 2004. 196. P.299-309. CrossRef PubMed
  11. Holroyde M.C., Eyre P. Reactivity of isolated bovine mesenteric and hepatic veins to vasoactive agents and specific antigen . Eur. J. Pharmacol. 1975. 30. P.36-42. CrossRef  
  12. Lautt W.W. The 1995 Ciba-Geigy Award Lecture. In­trinsic regulation of hepatic blood flow . Can. J. Physiol. and Pharmacol. 1996. 74, N 3. P.223-233. CrossRef PubMed
  14. Lautt W.W., Macedo M.P. Nitric oxide and the hepatic circulation . Nitric oxide and the regulation of the pe­ripheral circulation. 2000. P.243-258. CrossRef  
  15. McCuskey R.S. Morphologycal mechanisms for regulating blood flow through hepatic sinusoids . Liver. 2000. 20. P.13-17. CrossRef PubMed
  17. Rothe C.F., Maass-Moreno R. Hepatic venular resistance responses to norepinephrine, isoproterenol, adenosine, histamine and acetylcholine in rabbits . Amer. J. Physiol. 1998. 247. P.H777-H785. 11. Shibamoto T., Narushima M., Ling Y.O., Shimo T., Tsuchida H., Kurata Y. Different hepatic vascular response to noradrenaline and histsmine between uinea pig and rats . Acta. Physiol. Scand. 2004. 180. P.255-263. CrossRef PubMed
  19. Tchirikov M., Hubbard G.B., Hobe J., Nathanielsz P. W. Strictural evidence for mechanisms to redistrib­ute hepatic and ductus venous blood flows in nonhuman primate fetuses . Amer. J. Obstet. 2005. 192. P.1146-1152. CrossRef PubMed

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.