|
|
|
|
|
|
Anaesthetic and postanaesthetic effect of isoflurane on the multiple-unit activity of the immature rat hippocampus.
Isaeva EV, Isaev DS
O.O. Bogomoletz Institute of Physiology National Acad-emy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz57.01.017
Abstract
We investigated anesthetic and postanaesthetic effect of isoflurane on the multi-unit activity (MUA) in the CA3 region of immature rat hippocampus. MUA amplitude did not significantly change during application of isoflurane. On the other hand MUA frequency significantly decreased during the anesthesia. After isoflurane discontinuation two phases of MUA frequency recovery were observed: initial rapid increase followed by a slower recovery to the control level. Comparison of recovering period of the receptor mediated systems and spontaneous field activity from isoflurane anesthesia is discussed.
Keywords:
ізофлюран, електрична активністьнейронів, гіпокамп, щур
References
- Antkowiak B. Different actions of general anesthetics on the firing patterns of neocortical neurons mediated by the GABA(A) receptor . Anesthesiology. 1999. 91. P.500-511.
CrossRef
PubMed
- Banks M.I., Pearce R.A. Dual actions of volatile anesthetics on GABA(A) IPSCs: dissociation of blocking and prolonging effects . Ibid. 1999. 90. P.120-34.
CrossRef
PubMed
- Berg-Johnsen J., Langmoen I. A. Mechanisms concerned in the direct effect of isoflurane on rat hippocampal and human neocortical neurons . Brain Res. 1990. 507. P. 28-34.
CrossRef
- Cohen I., Miles R. Contributions of intrinsic and syn-aptic activities to the generation of neuronal discharges in in vitro hippocampus . J. Physiol. 2000. 524(2). P.485-502.
CrossRef
PubMed PubMedCentral
- el-Beheiry H., Puil E. Postsynaptic depression induced by isoflurane and althesin in neocortical neurons . Exp. Brain Res. 1989. 75. P.361-368.
CrossRef
PubMed
- Isaeva E. V. Effects of isoflurane on hippocampal sei-zures at immature rats in vivo . Fiziol. zhurn. 2008. 54(5). P.40-45.
- Isaeva E., Isaev D., Holmes G. L. Anesthetic and postanesthetic effects of isoflurane on neuronal activity in the rat hippocampus . Neurophysiology. 2007. 39. P.325-326.
CrossRef
- Isaeva E., Isaev D., Khazipov R., Holmes G.L. Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures . Eur. J. Neurosci. 2006. 23(6). P.1559-1566.
CrossRef
PubMed
- Jones M.V., Brooks P.A., Harrison N.L. Enhancement of gamma-aminobutyric acid-activated Cl- currents in cultured rat hippocampal neurones by three volatile anaesthetics . J. Physiol. 1992. 449. P.279-293.
CrossRef
PubMed PubMedCentral
- Jones M.V., Harrison N.L. Effect of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons . J. Neurophysiol. 1993. 70(4). P.1339-1349.
CrossRef
PubMed
- Ma J., Shen B., Stewart L.S. The septohippocampal system participates in general anesthesia . J. Neurosci. 2002. 22. P.1-6.
CrossRef
PubMedCentral
- Maclver M.B., Mikulec A.A., Amagasu S.M., Monroe F.A. Volatile anesthetics depress glutamate transmission via presynaptic actions . Anesthesiology. 1996. 85. P.823-34.
CrossRef
PubMed
- Nishikawa K., MacIver M.B. Excitatory synaptic transmission mediated by NMDA receptors is more sensitive to isoflurane than are non-NMDA receptor-mediated responses . Ibid. 2000. 92(1). P.228-236.
CrossRef
PubMed
- Ouanounou A., Carlen P.L., El-Beheiry H. Enhanced isoflurane suppression of excitatory synaptic transmission in the aged rat hippocampus . Brit. J. Pharmacol. 1998. 124. P.1075-1082.
CrossRef
PubMed PubMedCentral
- Philip B.K., Kallar S.K., Bogetz M.S. A multicenter comparison of maintenance and recovery with sevoflurane or isoflurane for adult ambulatory anesthesia. The Sevoflurane Multicenter Ambulatory Group . Anesth. Analg. 1996. 83(2). P.314-319.
CrossRef
- Ries C.R., Puil E. Mechanism of anesthesia revealed by shunting actions of isoflurane on thalamocortical neurons . J. Neurophysiol. 1999. 81(4). P.1795-1801.
CrossRef
PubMed
- Wakasugi M., Hirota K., Roth S.H., Ito Y. The effects of general anesthetics on excitatory and inhibitory synaptic transmission in area CA1 of the rat hippocampus in vitro . Anesth. Analg. 1999. 88. P. 676-680.
CrossRef
|
|
|
|
|
|
|
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
|
|