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Fiziologichnyi Zhurnal - <a id="lj1_ret_bk_to_jl0_href_id" href="?list0=12">Fiziol. Zh. 2010;</a> <a id="lj1_ret_bk_to_jl0_href_id" href="?list1=62">56(6):</a> 100-107
Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(6): 100-107

The effect of hyperthyreosis on thelearning and memory processes and thestate of the glial intermediate filamentsin rat brain

V.S. Nedzvetsky, P.A. Nerush.

    Dnepropetrovsk National University; Dnepropetrovsk StateMedical Academy


Abstract

The effects of hyperthyreosis on oxidative stress, state of glial intermediate filaments and memory were investigated. We observed a significant increase in lipid peroxidation products into both hippocampus and cortex and memory worsening. The changes of GFAP polypeptides was observed in hippoc­ampus and cortex. In group of rats with hyperthyreosis, the content of GFAP in both soluble and filamentous fractions was increased in hippocampus. This data shows, that glial cytoskeleton is reconstructed under thyroid hormone effects.

Full text: (PDF, in Ukrainian)

References

  1. Загородній М.П. Стан тиреоїдної активності та резистентності у дітей, що проживають в районах сумісної дії солей важких металів та малих доз радіації // Сум. держ. ун-т. - 1997. - 16 с. Укр. Ден. 28.07.97, №447.
  2. Кондор А.И. Современные проблемы тиреоидо-логии // Пробл. эндокринологии. - 1999. - 45, № 1. -С. 3-8.
  3. Кузьмина Н.С., Гаврилова Е.М., Александрова Л.М. Изучение неспецифических механизмов защиты организма и тиреоидного статуса у ликвидаторов последствий аварии на ЧАЭС в отдаленные сроки после катастрофы // Мед. консультація. - 1998. - 1. - С. 46-48.
  4. Лапач С. Н., Губенко А. В., Бабич П. Н. Статисти­ческие методы в медико-биологических исследо­ваниях с использованием Excel. Морион. - К., 2001. -408 с.
  5. Недзвецкий B.C., Березин В.А., Оберняк Т.И., Жмарева Е.Н. Характеристика специфических белков промежуточных филаментов в опухолях головного мозга человека // Биохимия. - 1986. - 51, №11. -С. 1843-1850.
  6. Недзвецкий B.C., Ушакова Г.А., Бусыгина С.Г., Березин В.А., Дворецкий А.И. Влияние малых доз ионизирующей радиации на промежуточные филаменты и Са2+-активируемую систему протео-лиза головного мозга крысы // Радиобиология. -1991. - 31, вып. 3. - С. 333-339.
  7. Сытник СИ., Стонсаров А.Н., Воронежский Б.К. Функциональное состояние тироидной системы у детей, облученных внутриутробно в результате Чернобыльской катастрофы // Пробл. эндокри­нологии. - 1999. - 45, № 1. -С. 26-29.
  8. Andres-Barquin P.J., Fages C., Le Prince G., Rolland B., Tardy M. Thyroid hormones influence the astroglial plasticity: changes in the expression of glial fibrillary acidic protein (GFAP) and of its encoding message // Neurochem. Res. - 1994. - 19, № 1. -P. 65-69.
  9. 9. Aydin M., Yilmaz B., Alcin E., Nedzvetsky V.S., Sahin Z., Tuzcu M. Effects of letrozole on hippocampal andcortical catecholaminergic neurotransmitter levels, neu­ral cell adhesion molecule expression and spatial learning and memory in female rats // Neuroscience. -2008. - 151. - P. 186-194.
  10. 10. Barber P.J., Elliott J. Study of calcium homeostasis in feline hyperthyroidism // J. Sm. Anim. Pract. - 1996. -37, №12. - P. 575-585.
  11. Baydas G., Koz S.T., Tuzcu M., Etem E., Nedzvetsky V.S. Melatonin inhibits oxidative stress and apoptosis in fetal brains of hyperhomocysteinemic rat dams // J. Pineal. Res. - 2007. - 43, № 3. - P. 225-231.
  12. Baydas G., Nedzvetskii V.S., Kirichenko S.V., Nerush P.A. Astrogliosis in the hippocampus and cortex and cognitive deficits in rats with streptozotocin-induced diabetes: effects of melatonin // Neurophysiology. -2008. - 40, №2. - P. 105-111.
  13. Bernal J., Nunez J. Thyroid hormones and brain de­velopment // Eur. J. Endocrinol. 1995. - 133, № 4. -P. 390-398.
  14. Bernal J. Thyroid hormones and brain development // Vitamins and Hormones. - 2005. - 71. - P. 95-122.
  15. Bernal J. Thyroid hormone receptors in brain develop­ment and function // Nat. Clin. Pract. Endocrinol. Metab. -2007. - 3, № 3. - P. 249-259.
  16. Eng L.F., Ghirnikar R.S., Lee Y.L. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000) // Neurochem. Res. - 2000. - 25, № 9-10. - P. 1439-1451.
  17. Farvell K., Tranter C, Leonard J.L. Thyroxine-depen-dent regulation of integrin-laminin interaction in astro­cytes // Endocrinology. - 1995. - 136, № 9. - P. 3909- 3915.
  18. Haddad F., Arnold C, Zeng M., Baldwin K. Interac­tion of thyroid state and denervation on skeletal myosin heavy chain expression // Muscle and nerve. - 1997. -20, № 12. - P. 1487-1496.
  19. 19. Hattori F., Oikawa S. Peroxiredoxins in the central nervous system // Subcell Biochem. - 2007. - 44. -P. 357-374.
  20. 20. King L., Schwartz N., Domowicz M. Glial migratory streams in the developing hindbrain: A slice culture approach // J. Neuroscience Methods. - 2009. - 177, №1. - P. 30-43.
  21. Manzano J., Bernal J., Morte B. Influence of thyroid hormones on maturation of rat cerebellar astrocytes // Int. J. Dev. Neurosci. - 2007. - 25, № 3. - P. 171-179.
  22. Miller G.L. Protein determination for large numbers of samples // Anal. Chem. - 1959. - 31, № 5. - P. 964-966.
  23. Motomura K., Brent G.A. Thyreotoxicosis // Endocri­nol. and Clin. Metabol. North Amer. - 1998. - 27, №1. - P. 1-23.
  24. Nunez J., Couchie D., Aniello F., Bridoux A.M. Thy­roid hormone effects on neuronal differentiation dur­ing brain development // Acta med. Austr. - 1992. - 19, №1. - P. 36-39.
  25. Aniello F., Couchie D., Gripois D., Nunez J. Regulation of five tubulin isotypes by thyroid hormone during brain development // Neurochem. - 1991. - 57, № 5. -P. 1781-1786.
  26. Nedzvetskii V.S., Tuzcu M., Yasar A., Baydas G. Ef­fects of vitamin E against aluminum neurotoxisity in rats // Biochemistry (Moscow). - 2006. - 71, № 3, P. 239-244.
  27. Roeder L.M., Hopkins I.B., Kaiser J.R., Hanukoglu L., Tildon J.T. Thyroid hormone action on glucose transporter activity in astrocytes // Biochem. and Biophys. Res. - 1988. - 156, № 1. - P. 275-281.
  28. Trentin A.G., De Aguiar C.B., Garcez R.C., Alvarez-Silva M. Thyroid hormone modulates the extracellular matrix organization and expression in cerebellar astro­cyte: effects on astrocyte adhesion // Glia. - 2003. -42, № 4. - P. 359-369.
  29. 29. Venero C, Herrero A.I., Touyarot K., Cambon K., Lypez-Fern6ndez M.A., Berezin V., Bock E., Sandi C. Hippocampal up-regulation of NCAM expression and polysialylation plays a key role on spatial memory // Eur. J. Neurosci. - 2006. - 23, № 6. - P. 1585-1595.
  30. 30. Zamoner A., Funchal C, Jacques-Silva M.C., Gottfried C, Barreto Silva F.R., Pessoa-Pureur R. Thyroid hormo­nes reorganize the cytoskeleton of glial cells through Gfap phosphorylation and Rhoa-dependent mechanisms // Cell Mol. Neurobiol. - 2007. - 27, № 7. - P. 845-865.
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