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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(6): 100-107


The effect of hyperthyroidism on the cognition processes and the state of the glial intermediate filaments in the rat brain

Nedzvets'kyĭ VS, Nerush PO

    Dnepropetrovsk National University; Dnepropetrovsk State Medical Academy, Ukraine
DOI: https://doi.org/10.15407/fz56.06.100

Abstract

The effects of hyperthyreosis on oxidative stress, state of glial intermediate filaments and memory were investigated. We observed a significant increase in lipid peroxidation products into both hippocampus and cortex and memory worsening. The changes of GFAP polypeptides was observed in hippoc­ampus and cortex. In group of rats with hyperthyreosis, the content of GFAP in both soluble and filamentous fractions was increased in hippocampus. This data shows, that glial cytoskeleton is reconstructed under thyroid hormone effects.

Keywords: glial intermediate filaments, hipertireosis, cognitive processe

References

  1. Zagorodnii M.P. Stan tireoidnoi aktivnosti ta rezistentnosti u ditei, shcho prozhivayut' v raionah sumisnoi dii solei vazhkih metaliv ta malih doz radiatsii . Sum. derzh. un-t. 1997. 16 s. Ukr. Den. 28.07.97, N 447.
  2.  
  3. Kondor A.I. Sovremennie problemi tireoido-logii . Probl. endokrinologii. 1999. 45, N 1. S. 3-8.
  4.  
  5. Kuz'mina N.S., Gavrilova E.M., Aleksandrova L.M. Izuchenie nespetsificheskih mehanizmov zashchiti organizma i tireoidnogo statusa u likvidatorov posledstvii avarii na ChAES v otdalennie sroki posle katastrofi . Med. konsul'tatsiya. 1998. 1. S. 46-48.
  6.  
  7. Lapach S. N., Gubenko A. V., Babich P. N. Statisti­cheskie metodi v mediko-biologicheskih issledo­vaniyah s ispol'zovaniem Excel. Morion. K., 2001. 408 s.
  8.  
  9. Nedzvetskii B.C., Berezin V.A., Obernyak T.I., Zhmareva E.N. Harakteristika spetsificheskih belkov promezhutochnih filamentov v opuholyah golovnogo mozga cheloveka . Biohimiya. 1986. 51, N 11. S. 1843-1850.
  10.  
  11. Nedzvetskii B.C., Ushakova G.A., Busigina S.G., Berezin V.A., Dvoretskii A.I. Vliyanie malih doz ioniziruyushchei radiatsii na promezhutochnie filamenti i Sa2+-aktiviruemuyu sistemu proteo-liza golovnogo mozga krisi . Radiobiologiya. 1991. 31, vip. 3. S. 333-339.
  12.  
  13. Sitnik SI., Stonsarov A.N., Voronezhskii B.K. Funktsional'noe sostoyanie tiroidnoi sistemi u detei, obluchennih vnutriutrobno v rezul'tate Chernobil'skoi katastrofi . Probl. endokri­nologii. 1999. 45, N 1. S. 26-29.
  14.  
  15. Andres-Barquin P.J., Fages C., Le Prince G., Rolland B., Tardy M. Thyroid hormones influence the astroglial plasticity: changes in the expression of glial fibrillary acidic protein (GFAP) and of its encoding message . Neurochem. Res. 1994. 19, N 1. P. 65-69. CrossRef PubMed
  16.  
  17. Aydin M., Yilmaz B., Alcin E., Nedzvetsky V.S., Sahin Z., Tuzcu M. Effects of letrozole on hippocampal andcortical catecholaminergic neurotransmitter levels, neu­ral cell adhesion molecule expression and spatial learning and memory in female rats . Neuroscience. 2008. 151. P. 186-194. CrossRef PubMed
  18.  
  19. Barber P.J., Elliott J. Study of calcium homeostasis in feline hyperthyroidism . J. Sm. Anim. Pract. 1996. 37, N 12. P. 575-585. CrossRef PubMed
  20.  
  21. Baydas G., Koz S.T., Tuzcu M., Etem E., Nedzvetsky V.S. Melatonin inhibits oxidative stress and apoptosis in fetal brains of hyperhomocysteinemic rat dams . J. Pineal. Res. 2007. 43, N 3. P. 225-231. CrossRef PubMed
  22.  
  23. Baydas G., Nedzvetskii V.S., Kirichenko S.V., Nerush P.A. Astrogliosis in the hippocampus and cortex and cognitive deficits in rats with streptozotocin-induced diabetes: effects of melatonin . Neurophysiology. 2008. 40, N 2. P. 105-111. CrossRef  
  24. Bernal J., Nunez J. Thyroid hormones and brain de­velopment . Eur. J. Endocrinol. 1995. 133, N 4. P. 390-398. CrossRef PubMed
  25.  
  26. Bernal J. Thyroid hormones and brain development . Vitamins and Hormones. 2005. 71. P. 95-122. CrossRef  
  27. Bernal J. Thyroid hormone receptors in brain develop­ment and function . Nat. Clin. Pract. Endocrinol. Metab. 2007. 3, N 3. P. 249-259. CrossRef  
  28. Eng L.F., Ghirnikar R.S., Lee Y.L. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000) . Neurochem. Res. 2000. 25, N 9-10. P. 1439-1451. CrossRef PubMed
  29.  
  30. Farvell K., Tranter C, Leonard J.L. Thyroxine-depen-dent regulation of integrin-laminin interaction in astro­cytes . Endocrinology. 1995. 136, N 9. P. 3909- 3915. CrossRef PubMed
  31.  
  32. Haddad F., Arnold C, Zeng M., Baldwin K. Interac­tion of thyroid state and denervation on skeletal myosin heavy chain expression . Muscle and nerve. 1997. 20, N 12. P. 1487-1496. CrossRef  
  33. Hattori F., Oikawa S. Peroxiredoxins in the central nervous system . Subcell Biochem. 2007. 44. P. 357-374. CrossRef PubMed
  34.  
  35. King L., Schwartz N., Domowicz M. Glial migratory streams in the developing hindbrain: A slice culture approach . J. Neuroscience Methods. 2009. 177, N 1. P. 30-43. CrossRef PubMed PubMedCentral
  36.  
  37. Manzano J., Bernal J., Morte B. Influence of thyroid hormones on maturation of rat cerebellar astrocytes . Int. J. Dev. Neurosci. 2007. 25, N 3. P. 171-179. CrossRef PubMed
  38.  
  39. Miller G.L. Protein determination for large numbers of samples . Anal. Chem. 1959. 31, N 5. P. 964-966. CrossRef  
  40. Motomura K., Brent G.A. Thyreotoxicosis . Endocri­nol. and Clin. Metabol. North Amer. 1998. 27, N 1. P. 1-23. CrossRef  
  41. Nunez J., Couchie D., Aniello F., Bridoux A.M. Thy­roid hormone effects on neuronal differentiation dur­ing brain development . Acta med. Austr. 1992. 19, N 1. P. 36-39.
  42.  
  43. Aniello F., Couchie D., Gripois D., Nunez J. Regulation of five tubulin isotypes by thyroid hormone during brain development . Neurochem. 1991. 57, N 5. P. 1781-1786. CrossRef PubMed
  44.  
  45. Nedzvetskii V.S., Tuzcu M., Yasar A., Baydas G. Ef­fects of vitamin E against aluminum neurotoxisity in rats . Biochemistry (Moscow). 2006. 71, N 3, P. 239-244. CrossRef PubMed
  46.  
  47. Roeder L.M., Hopkins I.B., Kaiser J.R., Hanukoglu L., Tildon J.T. Thyroid hormone action on glucose transporter activity in astrocytes . Biochem. and Biophys. Res. 1988. 156, N 1. P. 275-281. CrossRef  
  48. Trentin A.G., De Aguiar C.B., Garcez R.C., Alvarez-Silva M. Thyroid hormone modulates the extracellular matrix organization and expression in cerebellar astro­cyte: effects on astrocyte adhesion . Glia. 2003. 42, N 4. P. 359-369. CrossRef PubMed
  49.  
  50. Venero C, Herrero A.I., Touyarot K., Cambon K., Lypez-Fern6ndez M.A., Berezin V., Bock E., Sandi C. Hippocampal up-regulation of NCAM expression and polysialylation plays a key role on spatial memory . Eur. J. Neurosci. 2006. 23, N 6. P. 1585-1595. CrossRef PubMed
  51.  
  52. Zamoner A., Funchal C, Jacques-Silva M.C., Gottfried C, Barreto Silva F.R., Pessoa-Pureur R. Thyroid hormo­nes reorganize the cytoskeleton of glial cells through Gfap phosphorylation and Rhoa-dependent mechanisms . Cell Mol. Neurobiol. 2007. 27, N 7. P. 845-865. CrossRef PubMed

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