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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(6): 93-99


Interrelations of uric acid metabolism indices with insulin and testosterone levels in men with type 2 diabetes

Hurina NM, Korpacheva-Zinych OV, Shuprovych AA

    V.P. Komissarenko Institute of Endocrinology and Metabolism of Асademy of Medical Sciences, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz56.06.093

Abstract

95 men aged 45-65, suffering from type 2 diabetes for 0.1-20 years (4.5±1.4) were examined. Hypoandrogenia (serum testosteron < 10,4 nmol/ml) was noted in 37 % of investigated patients. Hyperuricemia (HUA), defined by serum uric acid (UAs) content more than 450 pmol/L, was detected in 34 % of subjects. In 74 % of patients there was a high level of 24h UA urine excretion (UAu>4.43 mmol), suggesting a hyperpro-duction of UA. Because the level of uricemia is defined by UA production and extretion, we outline two main types of alter­ations in UA methabolism: normouricemic, hyperuricosuric and hyperuricemic . In normouricemic and hyperuricosuric men UA excretion growth in parallel with the rate of kidney filtration, obesity, glicemia. High urate elimination index (UEI) suggests a decrease of UA reabsorbtion in kidney. The results allow us to suggest a significance of insulin and testosterone influence on regulation of UA metabolism in aged men with type 2 diabetes and insulin resistance syndrome.

Keywords: uric acid, metabolism, type 2 diabetes, insulin resistant syndrome, insulin, testosterone, men

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