Interrelations of uric acid metabolism indices with insulin and testosterone levels in men with type 2 diabetes
Hurina NM, Korpacheva-Zinych OV, Shuprovych AA
V.P. Komissarenko Institute of Endocrinology and Metabolism of Асademy of Medical Sciences, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz56.06.093
![](/images/cite.png)
Abstract
95 men aged 45-65, suffering from type 2 diabetes for 0.1-20 years (4.5±1.4) were examined. Hypoandrogenia (serum testosteron < 10,4 nmol/ml) was noted in 37 % of investigated patients. Hyperuricemia (HUA), defined by serum uric acid (UAs) content more than 450 pmol/L, was detected in 34 % of subjects. In 74 % of patients there was a high level of 24h UA urine excretion (UAu>4.43 mmol), suggesting a hyperpro-duction of UA. Because the level of uricemia is defined by UA production and extretion, we outline two main types of alterations in UA methabolism: normouricemic, hyperuricosuric and hyperuricemic . In normouricemic and hyperuricosuric men UA excretion growth in parallel with the rate of kidney filtration, obesity, glicemia. High urate elimination index (UEI) suggests a decrease of UA reabsorbtion in kidney. The results allow us to suggest a significance of insulin and testosterone influence on regulation of UA metabolism in aged men with type 2 diabetes and insulin resistance syndrome.
Keywords:
uric acid, metabolism, type 2 diabetes, insulin resistant syndrome, insulin, testosterone, men
References
- Balkarov I.M. Podagricheskaya (uratnaya) pochka. V kn: Diagnostika i terapiya v klinike vnutrennih bolez-nei. M.: Zdorov'e cheloveka, 2004. S.219-233.2. Ginzburg M.M., Kozupitsa G.S. Sindrom insulino-rezistentnosti . Probl. endokrinologii. 1997. 43,N 1. S.40-43.
- Demidova T.Yu., Ametov A.S., Titova I.O. Sovremennie vozmozhnosti korrektsii insulinorezis-tentnosti u patsientov s metabolicheskim sindromom . Terap. arhiv. 2006. 78, N 10. S. 36-40.
- Dudinskaya V., Hlinchak A., Skotnitskaya E., Suska M. Metabolizm purinov v eritrotsitah cheloveka (obzor) .Biohimiya. 2006. 71, N 5. S. 581-591.
- Kinev K.G. Podagra. M.: Meditsina, 1980. 124 s.
- Madyanov I.V., Balabolkin M.I., Markov D.S., Markova T.N. Osnovnie prichini giperurikemii pri saharnom diabete . Terap. arhiv. 2000. N 2. S.58-60.
- Muhin N.A., Balkarov I.M., Britov A.N. Tubulointerstitsial'nii nefrit i arterial'naya gipertoniya klinicheskoe i populyatsionnoe znachenie .Terap. arhiv. 1997. 69,N 7. S.5-10.
- Oranskaya A.N., Mkrtumyan A.M. Bolezn' bez vozrasta, bolezn' bez vremeni . Zdorov'e Ukraini. 2008. 1, N 182. S.36-37.
- Rukovodstvo po klinicheskoi laboratornoi diagnostike . Pod red. V.V.Men'shikova. M.: Meditsina, 1982. 576 s.
- ShamhalovaM.Sh.,KlefortovaI.I., Trubitsina N.P., Shestakova M.V. Porazhenie pochek pri SD 2-go tipa (obzor) . Terap. arhiv. 2006 . 78, N 10. S. 27-33.
- Shestakova M.V., Chugunova L.A., Shamhanova M.Sh. Diabeticheskaya nefropatiya: faktori riska bistrogo progressirovaniya pochechnoi nedostatochnosti .Terap. arhiv. 1999. N 6. S.45-49.
- Byrne C., Wareham N., Day N. Decreased non-esteri-fied fatty acid suppression and features and of the insulin resistance syndrome occur in a sub-group of individuals with normal glucose tolerance . Diabe-tologia. 1995. 38, N 11. P. 1358-1366.
CrossRef
PubMed
- Dodesini A., Lepore G., Tiengo A. Insulin resistance as a progression promoter in diabetic nephropathy . Ibid. 2004. 47 (S.1), A21 (Ref. 50).
- Fox J., Kelley W. Human phosphoribosylpy-rophosphate syntetase . J.Biol. Chem. 1972. 247, N 7. P. 2126-2131.
- Gazziola C, Ferraro P., Moras M. Cytosolic high Km 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism . J. Biol. Chem. 2001. 276, N 9. P. 6185-6190.
CrossRef
PubMed
- Geloneze S., Tambascia M., Parejra J. Non-esterified fatty acid (NEFA) release in vivo by visceral adipose tissue in humans . Diabetologia. 2004. 47, N 51, A 54, Ref. 139.
- Harman S.M., Metter E.J., Tobin J.D. Baltimore Longitudinal Study of Aging. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging . J. Clin. Endocrinol. and Metabol. 2001. 86. P. 724-731.
CrossRef
- Levinson D.J. Rat hepatic xanthine oxidase activity . Amer. J. Epidemiol. 2008. 23, N 1. P. 77-82.
CrossRef
PubMed
- Ljubojevic M., Herak-Kramberger C.M., Hagos Y., Bahn A., Endou H., Burckhardt G., Sabolic I. Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition . Amer. J. Physiol. Renal Physiol. 2004. 287. P. F124-F138.
CrossRef
PubMed
- Matsumoto S., Koshiishi I., Inoguchi T. Confirmation of superoxide generation via xantine oxidase in streptozotocin-induced diabetic mice . Free Radic. Res. 2003. 37,N 7. P.767-772. 21.
CrossRef
PubMed
- Matthews D., Hosker J., Rudenski A., Naylor B., Nreacer D., Turner R. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man . Diabetologia. 1985. 28. P. 412-419.
CrossRef
PubMed
- Nakagawa T., Tuttle K., Short R. Johnson R. J. Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome . Nat. Clin. Pract. Nephrol. 2005. N 1. P. 80-86.
CrossRef
PubMed
- Orwoll E., Lambert L.C., Marshall L.M. Testosterone and estradiol among older men . J. Clin. Endocrinol. and Metabol. 2006. 91, N 4. P. 1336-1344.
CrossRef
PubMed
- Pizzichini M., Leoncini R., Vannoni D., Marinello E., Pagani R. The influence of testosterone on purine nucleotide metabolism in rat liver . Life Sci. 1995. 57. P. 2127-2135.
CrossRef
- Reaven G. The kidney: An anwilling accomplice in syndrome X . Amer. J. Kidney Dis. 1997. 30, N 6. P. 928-931.
CrossRef
- Sala-Newby G.B., Freeman N.V., Skladanowski A.C. Distinct roles for recombinant cytosolic 5'-nucleotidase-I and II in AMP catabolism in COS-7 and H9c2 rat myoblast cell lines . J. Biol. Chem. 2000. 275, N 16. P. 11666-11671.
CrossRef
PubMed
- Sekine T., Miyazaki H., Endou H. Molecular physiology of renal organic anion transporters . Amer. J. Physiol. Renal Physiol. 2006. 290. P. F251-F261.
CrossRef
PubMed
- Taniguchi Y, Hayashi T., Tsumura K., Endo G., Fujii S., Okada K. Serum uric acid and risk for hypertension and type 2 diabetes in Japanese men: The Osaca Helth Survey . J. Hypertens. 2001. 19, N 7. P.1209-1215.
CrossRef
PubMed
- Vizzotto L., Vartemati M., Marinello E., Leoncini R. Pagani R., Pizzichini M. Effect of testosterone on purine metabolism and morphometric parameters in the rat liver . Mol. Cell. Endocrinol. 1996. 119. P. 123-127.
CrossRef
- Xiang G., Qi Lu, Qiao N. Intake of added sugar and sugar-sweetened drink and serum uric acid concentration in us men and women . Hypertension. 2007. 50. P. 306.
CrossRef
PubMed
|