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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(6): 81-92


Long-term effect of fetal neural tissue late grafting on hippocampus cytoarchitecture after transient global cerebral ischemia in rats

Harashchuk OV, Tsupykov OM, Tsymbaliuk VI

  1. O.O. Bogomoletz National Medical University, Kyiv, Ukraine
  2. O.O. Bogomoletz Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz56.06.081

Abstract

The effect of fetal neural tissue (FNT) grafting on regeneration of hippocampus structure has been investigated in postis­hemic rats. Transient global cerebral ischemia was induced by 20-min four-vessel occlusion in 13.2±2.4-month-old rats. FNT suspension was prepared from hippocampal CA1 area and primordial dentate gyrus of E18-E19 rat fetuses. 30 days after TGI, FNT was stereotactically transplanted into CA1 area of ischemic animals. Linear density of CA1 pyramidal neurons, stratum radiatum width, CA4 and dentate gyrus morphology were studied in hippocampal slices by light microscopy 2, 4 and 7 months after TGI and 1, 3 and 6 months after FNT grafting. It has been shown, that late FNT grafting provides significant and prolonged potentiation of a hippocampal cy-toarchitecture recovery after TGI in rats.

Keywords: fetal neural tissue, forebrain global ischemia, stereotaxic grafting, hippocampus

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