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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(6): 70-80


Cathepsin-like activity in blood plasma of patients with papillary thyroid carcinoma

Kalinichenko OV, Myshunina TM, Tron'ko MD.

    State Institution «V.P. Komisarenko Institute of Endocrinol-ogy and Metabolism of AMS of Ukraine», Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz56.06.070

Abstract

The peculiarities of the thyroid changes depending on clinical characteristics of disease and histological structure of tumor were fixed by the studies of cathepsin-like activity in blood plasma of patients with papillary thyroid carcinoma. H-cathepsin-like activity had a tendence to more significant in­crease especially in patients with concomitant benign thyroid disease with increasing the tumor category. In a case of methastatic tumor without other concomitant thyroid pathol­ogy, the degree of an increase in enzymatic activity was sig­nificantly higher comparing to the blood of patients without tumor metastases. B-cathepsin-like activity in blood plasma of patients only with tumor carcinoma was at the level of that of healthy subjects. B-cathepsin-like activity in blood plasma had especially significant increased under tumor T1 category that was connected with nodular goiter or adenoma in a case concominant carcinoma by other thyroid pathology. In pa­tients with carcinoma that was diagnosed against a background of concomitant pathology, the insignificant increase in L-cathepsin-like activity was not dependent on clinical fea­tures of disease, while in a case of carcinoma without concomitant pathology a degree of its increase was certainly dependent on a category of tumor T, its histological structure and the presence of oxyphilic cell metaplasia. We failed to get an evidence linking the changes in cathepsine-like activity in blood with the processes of intra- or extrathyroid invasion and invasion into the lymphatic or blood vessels. The results of the studies do not provide a rationale to consider that the cathepsine-like activity in blood of patients with papillary thyroid carcinoma can be the valuable additional biochemical criterion for differential diagnosis, estimation of the severity, and other characteristics of the disease.

Keywords: Cathepsine B, H, L, papillary carcinoma, concomitant benign thyroid pathology, blood

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