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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(6): 55-61


The changes of oxidative-reductive processes and fatty acid composition of liver lipids in rats with streptozotocin-induced diabetes

Khavrona OP, Fartushok NV, Fedevych IuM, Sol's'ki Ia, Skliarov OIa

  1. Danylo Halytsky Lviv National Medical University, Ukraine
  2. Lublin Medical University, Ukraine
DOI: https://doi.org/10.15407/fz56.06.055

Abstract

The processes of lipid peroxidation, oxidative modification of proteins, the state of antioxidant protection system enzymes and fatty acid composition of liver lipids were investigated in rats with streptosotocin-induced diabetes. The development of diabetes is accompanied by oxidative stress, which results in the activation of lipid peroxidation processes and the increase in the amount of nitrogen oxide and the activity of antioxidant protection system enzymes. The increase of the amount of saturated fatty acid and fall in the amount of unsaturated fatty acid has been detected. The rise of the processes of protein oxidation was established, which can lead to loss of their biological activity.

Keywords: lipid peroxidation, oxidative modification of proteins, antioxidant protection system, glutathione system, fatty acids, nitric oxide, diabetes.

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