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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(6): 48-54


Action of red polarized light on the acupuncture point E-36 increases analgesic effect of corvitin

Tamarova ZA, Lymans'kyĭ IuP, Kostiuk OI, Mitruzaeva VA

    O.O.Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz56.06.048


Abstract

In experiments on mice of lines C57BL/6J and CBA/CaLac, the possibility of strengthening of analgesic effect of corvitin by the action of red polarized light (PL) on the acupoint (AP) E-36 was studied. The pain behavioral response (licking of the painful area) was caused by injection of 5% formalin in hind limb (0.25 ul subcutaneously). The duration of pain response was studied before and after systemic introduction of corvitin (10 mg/kg, intraperitoneal) or joint use of corvitin and red PL (10 minute session). It is established, that after application of red PL on the antinociceptive AP E-36 in all animals an authentic strengthening of antinociceptive effect of corvitin takes place. In C57BL/6J mice, application of corvitin alone weakened the pain response by 29.7% and during combined use of red PL and corvitin, it grew up to 53.1%. Mice of line CBA/CaLac were less sensitive both to corvitin, and PL. In this line, corvitin used alone reduced the duration of pain response by 14%, and by 32.4% during combined use with red PL. Non-traumatic, without side effects, the method of influence by low-intensive PL can be recommended to patients accepting corvitin for strengthening its efficiency.

Keywords: corvitin, polarized light, formalin test, analgesia, acupuncture point E-36

References

  1. Limansky YP, Bogatskaya OV, Gura OV, Nesin OM, Sushko B.C., Tamarova Z. Effect of Corvitin on somatic pain in mice of different genotypes . Fiziol zh. . 2008. 54, N 4. P. 37-43.
  2.  
  3. Limans'kii Yu.P., Gura O.V., Sushko B.S., Tamarova Z.A. Osoblivosti analgetichnoi dii korvitinu u mishei riznih genetichnih linii. U kn.: Tezi dop.. IV konf. Ukr. suspil'stva neironauk, Donets'k-Slov'yans'k, 2008. S41.
  4.  
  5. Limansky YP, Tamarova SA, Gulyar CO. The effect of color polarized light on tonic pain in mice. In the book: Materials .HOP of the Congress of the Ukrainian Physiol. society with international. participation, Chernivtsi, May 18-20, 2006 . Fiziol zh. . 2006. 52. N 2. P. 44.
  6.  
  7. Maksyutina N.P., Moibenko O.O., Parhomenko O.M., Myasoedov D.V. Vikoristannya novih likars'kih form kvertsetinu pri ishemichnih ta radiatsiinih ushkodzhennyah : Metod. rekomendatsii. K., 2000. 13 s.
  8.  
  9. Moibenko O.O., Dosenko B.C., Parhomenko A.N. Endogennie mehanizmi kardioprotektsii kak osnova patogeneticheskoi terapii zabolevanii serdtsa. K.: Nauk. dumka, 2008. 520 s.
  10.  
  11. Nesin E.N., Gura E.V. Anal'geziya, indutsirovannaya kombinirovannim primeneniem tramadola i mikro­volnovogo oblucheniya pri somaticheskoi boli u mishei . Neirofiziologiya . Neurophysiology. 2006. 38, N 4. S. 314-320. CrossRef  
  12. Nesin O.M., Kolbun M.D., Gura O.V. Kombinovane zastosuvannya farmakologichnih analgetikiv ta mikrohvil'ovogo oprominennya tochki akupunkturi dlya prignichennya vistseral'nogo bolyu u mishei: rol' opioidnoi ta serotoninergichnoi sistem mozku . Neurophysiology. 2007. 39, N 6. S 470-478. CrossRef  
  13. Tamarova SA, Limansky YP, Gulyar CO. Comparative study of the intensity of the analgesic action of polarized light and analgesics . Fiziol zh. . 2005. 51, N 2. P. 7-64.
  14.  
  15. Amanpreet S., Pattipati S.N., Shrinivas K.K. Quer-cetin, a bioflavonoid, reverses development of toler­ance and dependence to morphine . Drug Dev.Res. 2002. 57. P. 167-172. CrossRef  
  16. Anjane M., Chopra R.K. Reversal of lipopoly-saccaharide-induced thermal and behavioural hyperal­gesia by quercetin . Drug Dev.Res. 2003. 58. P. 248-252. CrossRef  
  17. Anjaneyulu M., Chopra K. Quercetin, a bioflavonoid, attenuates thermal hyperalgesia in a mouse model of diabetic neuropathic pain . Prog. Neuropsycho-pharmacol. Biol. Psychiatry. 2003. 27, N 6. P.1001-1005. CrossRef  
  18. Chuyan E.N., Dzheldubayeva H.R. Roles of different neurochemical systems in mechanisms underlying the antinociceptive effect of extrahigh-frequency electro­magnetic radiation . Neirofiziologiya . Neuro­physiology. 2007. 39, N 2. P.165-173. CrossRef  
  19. Dubuisson D., Dennis S.G. The formalin test: a quan­titative study of the analgesic effects of morphine, meperidine and brain stem stimulation in rats and cats . Pain. 1977. 4. P.161-174. CrossRef  
  20. Filho A.W., Filho V.C, Olinger L., de Souza M.M. Quercetin: further investigation of its antinociceptive properties and mechanisms of action . Arch. Pharm. Res. 2008. 31,N 6. P.713-21. CrossRef PubMed
  21.  
  22. Gadotti V.M., Schmeling L.O., Machado C, Liz F.H., Cechinel F.V., Meyre S.C, Santos A.R. Antinociceptiveaction of the extract and the flavonoid quercetin iso­lated from Bauhinia microstachya leavels . J. Pharm. Pharmacol. 2005. 57. P.1345-1351. CrossRef PubMed
  23.  
  24. Gulyar S.A., Limansky Y.P., Tamarova Z.A. Suppres­sion of pain by influence of bioptron-polarized light on acupoints . Pain. 2006. 10. P. 212. CrossRef  
  25. Hanskaar S., Hole K. The formalin test in mice: disso­ciation between inflammatory and non-inflammatory pain . Pain. 1987. 30. P.103-104. CrossRef  
  26. Kaur R., Singh D., Chopra K. Participation of alpha2 receptors in the antinociceptive activity of quercetin . J. Med. Food. 2005. 8, N 4. P.529-532. CrossRef PubMed
  27.  
  28. Limansky Y.P, Tamarova Z.A., Gulyar S.A. Suppres­sion of pain by exposure of acupuncture points to polarized light . Pain Research & Management. 2006. 11, N 1. P. 49-57. CrossRef PubMed PubMedCentral
  29.  
  30. Naidu P.S., Singh A., Joshi D., Kulkarni S.K. Possible mechanisms of action in quercetin reversal of morphine tolerance and dependence . Addict Biol. 2003. 8, N 3. P.327-336. CrossRef PubMed
  31.  
  32. Nesin E. Suppression of synthesis of serotonin: effect on antinociception induced by microwave irradiation and analgesic remedies . Neirofiziologiya . Neurophysiology. 2006. 38, N 5. 6. C.498-499. CrossRef  
  33. Ojewole J.A.O. Anti-Inflammatory and analgesic ef­fects of Psidium guajava Linn. (myrtaceae) leaf aque­ous extracts in rats and mice . Methods Find Exp Clin Pharmacol. 2006. 28, N 7. P. 441. CrossRef PubMed
  34.  
  35. Rulski M., Duriasz-Rowinska H., Rewerski W. The analgesic action of some flavonoids in the hot plate test . Acta Physiol. Pol. 1979. 57, N 3. P.385-388.
  36.  
  37. Tamarova Z.A., Limansky Y.P., Gulyar S.A. Antino­ciceptive effects of color polarized light in animal with formalin test . Fiziol. zhuri. 2009. 55, N 3. C.81-93.
  38.  

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