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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(6): 12-21

Effect of iontophoretically administered L-DOPA and ketamin on the impulse activity of the somatomotor cortex neurons during the conditioned placing movements

Khorievin VI

    O.O. Bogomolets Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv, Ukraine


Interactions between the neuronal dopamine and NMDA glutamate receptors were investigated by iontophoresis of L-DOPA and ketamin to 19 single cortical neurons of the somatomotor cortex neurons in cats performing the operant reflex. L-DOPA producing bursts of 8-12 impulses that led to the significant increase of the total number of spikes related to the movements and insignificant decreased the power or the average number of spikes in a conditional response. Effects of ketamin on impulse activity were multidirectional resulting in most cases (16 cells) in the significant increase of the response power and in other three cells producing the suppression of discharges related to movements. It is supposed that follow­ing the ketamin iontophoresis the facilitation of conditional responses was caused by the blocking of the NMDA-glutamatergic transmission to intracortical inhibitory neurons, whereas inhibition of conditioned responses of other cortical cells was produced by blocking NMDA-glutamatergic trans­mission to pyramidal neurons. The total number of spikes associated with the performance of movements following the joint application of L-DOPA and ketamin was significantly higher compared with the effect of the isolated L-DOPA ion­tophoresis. These data indicate the NMDA-glutamatergic trans­mission, which plays an important role in shaping the cortical neuron responses in the performance of behavioral reactions may be modulated by L-DOPA.

Keywords: neuron, cerebral cortex, the impulse activity, L-DOPA, ketamin, conditioning.


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