Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(5): 106-114


Role of glycosaminoglycans in pathogenesis of atherosclerosis

Sukmans'kyĭ OI, Drohomyrets'ka MS, Den'ha OV, Sukmans'kyĭ IO

  1. Odesa State Agrarian University, Ukraine
  2. P.L.Shupik National Medical Academy of Post-graduateEducation, Kyiv, Ukraine
  3. Institute of Stomatology AMS of Ukraine, Odesa, Ukraine
DOI: https://doi.org/10.15407/fz56.05.106

Abstract

In this review we summarize the role of glycosaminoglycans and proteoglycans in pathogenesis of atherosclerosis and possibilities for correction of lesions of atherosclerotic vessels via influence on their metabolism.

Keywords: glycosaminoglycans, proteoglycans, athero-sclerosis, arterial wall

References

    Berezovsky V.Ya., Litovka IG, Kostyuchenko OS Physiological bone regeneration under dosage normobaric hypoxia . Fiziol zh. . 2007. 57, N 6. P.40-45.   Boiko E. P., Kaneva A.M. Apoproten E i ego znachenie v klinicheskoi fiziologii. Uspehi fiziol. nauk. 2009. 40,N 1. S.3-15.   Gorohivskii V.N., Podorozhnaya R.P., Sukmanskii O.I., Den'ga O.V., Knava O.E., Makarenko O.A. Narusheniya sinteza glikozaminoglikanov pri eksperimental'nom flyuoroze i puti ih korrektsii. . Ros. stomatol. zhurn. 2008, N 1. S.11-13.   Dil'man V.M. Starenie, klimaks i rak. L., 1968. 130 s.   Drogomiretskaya M.S., Sukmanskii O.I., Den'ga O.V., Makarenko O.A., Podorozhnaya R.P., Knava O.E. Obmen glikozaminoglikanov (GAG) v tkanyah polosti rta i nekotorih vnutrennih organah pri eksperi­mental'nom ateroskleroze i ego lechenii na fone ortodonticheskogo vmeshatel'stva.Visn. stoma­tologii. 2007. N 3. C.11-16.   Drogomiretskaya M.S., Sukmanskii O.I., Den'ga O.V. Podorozhnaya R.P., Knava O.E. Obmen serosoder­zhashchih soedinenii pri eksperimental'nom atero­skleroze. YaP Mizhnar. nauk. konf. "Gomeostaz, fiziologiya, patologiya, farmakologiya i klinika": Tezi dop., Odesa, 2007. S.39-40.   Ievdokimova N.Yu. Gialuronova kislota, retseptor CD44 ta ihnya rol' v uskladnennyah tsukrovogo diabetu.Ukr.biohim. zhurn. 2008. 80, N 5. S.5-44.   Krasnikova T.L., Aref'eva T.P., Kuhtina N.B. Hemokini, retseptori hemokinov i aterogenez. Uspehi sovrem. biologii. 2003. 123,N 5. S.506-514.   Nagornev V.A., Voskan'yants A.N. Aterogenez kak immuno-vospalitel'nii protsess. Vesti. RAMN. 2004. N 7. S.3-11.   Sidorenko B.A., Zaikina N.V., Preobrazhenskii D.V. Enoksaparin i drugie nizkomolekulyarnie geparini v kardiologii.Kardiologiya. 1998. N 10. S.82-90.   Sidorenko B.A., Preobrazhenskii D.V. Nizko­molekulyarnie geparini: vozmozhnost' primeneniya. Kardiologiya. 1995. N 10. S.86-91.   Stoika R.S., Fil'chenkov A.A., Zalesskii V.N. Tsitokini i kletki-misheni v regulyatornoi sisteme aterogeneza.Uspehi sovrem.biologii. 2003. 123,N 1. S.82-97.   Sudans'kii O.I. Tsitokini nova sistema bioregu-lyatoriv .Visn. stomatologii. 2005. N 3. S.69-74.   Sukmans'kii O.I., Gorohivs'kii V.N. Glikoza-minoglikani (GAG) i kistkova tkanina.Visn. stomatologii. 2009. N 3. S.113-118.   Tsurko V.V., Leonenko I.V., Egorov I.V., Krasno­sel'skii M.Ya. Rol' mediatornih mehanizmov v immunopatogeneze vospaleniya pri serdechno­sosudistih zabolevaniyah i osteoporoze.Terap. arhiv. 2009. 81, N 6. S. 92-96.   Allain F., Vanpouille C., Carpentier M. Slomianny M.C., Durieux S., Spik G. Interaction with glycosami-noglycans is required for cyclophilin B to trigger integrin-mediated adhesion of peripheral blood T-lymphocytes to extracellular matrix. Proc. Nat. Acad. Sci. USA. 2002. 99, N 5. P.2714-2719. CrossRef PubMed PubMedCentral   Bot P.T., Hoefer I.E., Piek J.J., Pasterkamp G. Hyaluronic acid: targeting immune modulatory components of the extracellur matrix in atherosclero-sis.Curr. Med. Chem. 2008. 5. N 8. P.786-791. CrossRef PubMed   Chai S., Chai Q., Danielsen C.C., Hjorth P., Nyengaard J.R., Ledet T., Yamaguchi Y., Rasmussen L.M., Wogensen L. Overexpression of hyaluronan in the tu­nica media promotes the development of atherosclero-sis.Circulat. Res. 2005. 96. N 5. P.583-591. CrossRef PubMed   Dadlani H., Ballinger M.L., Osman N., Getachew R., Little P.J. Smad and p38 MAP kinase-mediated signaling of proteoglycan synthesis in vascular smooth muscle.J. Biol. Chem. 2008. 283. N 12. P.7844-7852. CrossRef PubMed   Deepa P .R., Varalakshmi P. Atheroprotective effect of exogenous heparin-derivative treatment on the aortic disturbances and lipoprotein oxidation in hypercho-lesterolemic diet fed rats.Clin. Chim. Acta. 2005. 355,N 1-2. P.l19-130. CrossRef PubMed   Deepa PR., Varalakshmi P. Favourable modulation of the inflammatory changes in hypercholesterolemic athero-genesis by a low-molecular-weight heparin derivative. Int. J. Cardiol. 2006. 106, N 3. P.338-347. CrossRef PubMed   Delmolino L.M., Stearns N.A, Castellot Jr. J.J. COP-l, a member of the CCN family, is a heparin-induced growth arrest specific gene in vascular smooth muscle cells.J. Cell Physiol. 200I. 188, N 1. P.45-55. CrossRef PubMed   De Lorenzo F., Dotsenko O., Kakkar YY. Low molecular weight heparins in cardiovascular medicine. Minerva Cardioangiol. 2005. 53, N 6. P.585-603.   Duan Y, Paka L., Pillarisetti S. Distinct effects of glucose and glucosamine on vascular endothelial and smooth muscle cells: evidence for a protective role for glucosamine in atherosclerosis.Cardiovasc. Diabetol. 2005. 4. P. 16. CrossRef PubMed PubMedCentral   Elhadj S., Mousa S.A., Forsten-Williams K. Chronic pulsatile shear stress impact synthesis of proteo­glycans by endothelial cells effect on platelet aggrega­tion and coagulationJ. J. Cell Biochem. 2002. 86, N 2. P.239-250. CrossRef PubMed   Fischer J. W., Schrnr K. Regulation of hyaluronan syn­thesis by vasodilatory prostaglandins. Implications for atherosclerosis.Throm. Haemost. 2007. 98, N 2. P.287-295. CrossRef PubMed   Gounffic Y, Guilluy C, Guirin P., Patra P., Pacaud P., Loirand G. Hyaluronan induces vascular smooth muscle cell migration through RHAMM-mediated PI3K-de-pendent Rac activation.Cardiovasc. Res. 2006. 72, N 2. P.339-348. CrossRef PubMed   Hamati H.F., Britton E.L., Carey D.J. Inhibition of proteoglycan synthesis alters extracellular matrix depo­sition, proliferation, and cytoskeletal organization of rat aortic smooth muscle cells in culture.J. Cell Biol. 1989. 108,N 6. P.2495-2505. CrossRef PubMed PubMedCentral   Herrero-Beaumont G., Marcos M.E., S6nchez-Pernaute O., Granados R., Ortega L., Montell E., Vergfis J., Egido J. Effect of chondroitin sulphate in a rabbit model of atherosclerosis aggravated by chronic arthritis.Brit. J. Pharmacol. 2008. 154, N 4. P.843-851. CrossRef PubMed PubMedCentral   Iwasaki S., Minamisawa S., Yokoyama U., Akaike T., Quan H., Nagashima Y, Nishimaki S., Ishikawa Y Interleukin-15 inhibits smooth muscle cell prolifera­tion and hyaluronan production in rat ductus arteriosus. . Pediatr. Res. 2007. 62, N 4. P.392-398. CrossRef PubMed   Kumar v., Cotran R.S., Robbins S.L. Robbins Basic Pathology. 7th ed. Philadelphia, London, Toronto etc.: W.B. Saunders Company, 2003. 873 p.   Lake A.C., Bialik A., Walsh K., Castellot J.J. CCN5 is a growth arrest-specific gene that regulates smooth muscle cell proliferation and motility. Amer. J. Pathol. 2003. 162, N 1. P.219-231. CrossRef   Lee M., Sommerhoff C.P., von Eckardstein A., Zettl F., Fritz H., Kovanen P.T. Mast cell tryptase degrades HDL and blocks its function as an acceptor of cellular cholesterol. Arterioscler. Thromb. Vasc. Biol. 2002. 22,N 12. P.2086-2091. CrossRef PubMed   Libeu C.P, Lund-Katz S., Phillips M.C., Wehrli S., Hernaiz M.J., Capila I., Linhardt R.J., Raffai R.L., Newhouse YM. New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E.J. Biol. Chem. 2001. 276, N 42. P.39138-39144. CrossRef PubMed   Little. P.J., Ballinger M.L., Burch M.L., Osman N. Biosynthesis of natural and hyperelongated chondroi­tin sulfate glycoaminoglycans: new insights into an elusive process. Open Biochem. J. 2008. 2. P.135-142. CrossRef PubMed PubMedCentral   McDonald T.O., Gerrity R.G., Jen C, Chen H.J., Wark K., Wight T.N., Chait A., O'Brien K.D. Diabetes and arterial extracellular matrix changes in a porcine model of atherosclerosis. J. Histochem. Cytochem. 2007. 55, N 11. P.1149-1157. CrossRef PubMed PubMedCentral   Mahley R.W., Huang Y. Atherogenic remnant lipoproteins: role for proteoglycans in trapping, trans­ferring, and internalizing.J. Clin. Invest. 2007. 117, N 1. P.94-98, 153-174. CrossRef PubMed PubMedCentral   Marks D.B. Biochemistry. 2nd ed. Philadelphia, Balti­more, Hong Kong, London etc.: Harwal Publishing, 1994. 337 p.   Mine S., Okada Y, Kawahara C, Tabata T., Tanaka Y Serum hyaluronan concentration as a marker of angi-opathy in patients with diabetes mellitus. Endocr. J. 2006. 53,N 6. P.761-766. CrossRef PubMed   Mishra-Gorur K., Delmolino L.M., Castellot Jr. J.J. Biological function of heparan sulfate and heparan sul­fate proteoglycans.Trends Glycosci. Glycotechnol. 1998. l0. P.l93-210. CrossRef   Nieuwdorp M., Holleman F., de Groot E., Vink H., Gort J., Kontush A., Chapman M.J., Hutten B.A. Per­turbation of hyaluronan metabolism predisposes pa­tients with type 1 diabetes mellitus to atherosclerosis. . Diabetologia. 2007. 50, N 6. P.I288-1293. CrossRef PubMed PubMedCentral   Nieuwdorp M., Meuwese M.C., Mooij H.L. van Lie-shout M.H., Hayden A., Levi M., Meiers J.C., Ince C, Kastelein J.J. Tumor necrosis factor-alpha inhibition protects against endotoxin-induced endot­helial glycocalyx perturbation.Atherosclerosis. 2009. 202,N 1. P.296-303. CrossRef PubMed   Nishimura M., Ookawara T., Eguchi H., Fujiwara N., Yoshihara D., Yasuda D., Mimura O., Suzuki K. Inhibition of gene expression of heparin binding epi­dermal growth factor-like growth factor by extracellu­lar superoxide dismutase in rat aortic smooth muscle cells. Free Radic. Res. 2006. 40, N 6. P.589-595. CrossRef PubMed   Potter D.R., Damiano E.R. The hydrodynamically relevant endothelial cell glycocalyx observed in vivo is absent in vitro. Circulat. Res. 2008. 102, N 7. P.747-748. CrossRef PubMed   Qui G., Hill J.S. Endothelial lipase promotes apolipoprotein AI-mediated cholesterol efflux in THP-1 macrophages.Arterioscler. Thromb. Vasc. Biol. 2009. 29,N 1. P.84-91. CrossRef PubMed   Ranjbaran H., Wang U., Manes T.D., Yakimov A.O., Akhtar S., Kluger M.S., Pober J.S., Tellides G. Hep­arin displaces interferon-gamma-inducible chemokines (IP-I0, I-TAC, and Mig) sequestered in the vascula­ture and inhibits the transendothelial migration and arterial recruitment of T cells.Circulation. 2006. 114,N 12. P.1293-1300. CrossRef PubMed   Ross. R. Atherosclerosis an inflammatory disease. N. Engl. J. Med. 1999. 340. P.115-126. CrossRef PubMed   Sakr S.W., Potter-Perigo S., Kinsella M.G., Johnson P.Y, Braun K.R., Goueffic Y, Rosenfeld M.E., Wight T.N. Hyaluronan accumulation is elevated in cultures of low density lipoprotein receptor-deficient cells and is altered by manipulation of cell cholesterol content. J. Biol. Chem. 2008. 283, N 52. P.36195-36204. CrossRef PubMed PubMedCentral   Seike M., Ikeda M., Matsumoto M., Hamada R., Takeya M., Kodama H. Hyaluronan forms complexes with low density lipoprotein while also inducing foam cell infiltration in the dermis. J. Dermatol. Sci. 2006. 41,N 3. P.197-204. CrossRef PubMed   Slevin M., Krupinski J., Gaffney J., Matou S., West D., Delisser H., Savani R.C, Kumar S. Hyaluronan-mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways. Matrix Biol. 2007. 26, N l. P.58-68. CrossRef PubMed   Stoll G., Bendszus M. Inflammation and atherosclero­sis: novel insights into plaque formation and destabi-lzation.Stroke. 2006. 37, N 7. P.1923-1932. CrossRef PubMed   Tabata T., Mine S., Okada Y, Tanaka Y Low molecular weight hyaluronan increases the uptaking of oxidized LDL into monocytes. Endocr. J. 2007. 54, N 5. P.685-693. CrossRef PubMed   Tasaki H., Yamashita K., Tsutsui M., Kamezaki F., Kubara T., Tanaka S., Sasaguri Y, Adachi T., Nakashima Y Heparin-released extracellular superoxide dismutase is reduced in patients with coronary artery athero­sclerosis. Atherosclerosis. 2006. 187, N 1. P.131-138. CrossRef PubMed   Theocharis A.D., Tsolakis I., Tzanakakis G.N., Kara-manos N.K. Chondroitin sulfate as a key molecule in the development of atherosclerosis and cancer progres­sion. Adv. Pharmacol. 2006. 53. P.281-295. CrossRef   Tollefsen D.M. Heparin cofactor II modulates the response to vascular injury. Arterioscler. Thromb. Vasc. Biol. 2007. 27, N 3. P.454-460. CrossRef PubMed   Tovar A.M., Pecly I.M., Rangel E.P., Melo-Filho N.M., Mourro P.A., Leite M. Jr. Experimentally in­duced metabolic acidosis in rabbits modulates the in­teraction of aortic glycosaminoglycan with plasma low-density lipoprotein an interesting observation about the association of acidosis and atherosclerosis. Ath­erosclerosis. 2007. 192, N 1. P.33-39. CrossRef PubMed   Vicente C.P., He L., Tollefsen D.M. Accelerated athero-genesis and neointima formation in heparin cofactor II deficient mice.Blood. 2007. 110, N 13. P.4261-4267. CrossRef PubMed PubMedCentral   Vigetti D., Viola M., Karousou E., Rizzi M., Moretto P., Genasetti A., Clerici M., Hascall V.C., De Luca G., Passi A. Hyaluronan-CD44-ERKl. 2 regulate human aortic smooth muscle cell motility during aging.J. Biol. Chem. 2008. 283, N 7. P.4448-4458. CrossRef PubMed   Wong K.S., Chen C, Ng P.W., Tsoi T.H., Li H.L., Fong W.C. Low-molecular-weight heparin compared with as­pirin for the treatment of acute ischaemic stroke in Asian patients with large artery occlusive disease: a randomized study.Lancet Neurol. 2007. 6, N 5. P.407-413. CrossRef   Yao Y, Rabodzey A., Dewey C.F. Jr. Glycocalyx modu­lates the motility and proliferative response of vascular endothelium to f1uid shear stress. Amer. J. Physiol, Heart Circ.Physiol. 2007. 293. N 2. P.H1023-1030. CrossRef PubMed   Zhao L., Lee E., Zukas A.M., Middleton M.K., Kinder M., Acharya P.S., Hall J.A., Rader D.J., Puri E. CD44 expressed on both bone marrow-derived and non-bone marrow-derived cells promotes atherogenesis in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 2008. 28. N 7. P.1283-1289. CrossRef PubMed  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.