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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(5): 77-85


Effect of L-arginine and aminoguanidine on morphological characteristics of the lymphocyte plasma membranes during experimental diabetes mellitus

Brodiak IV, Hnatush AR, Sybirna NO.

    Ivan Franko National University of L’viv, Ukraine
DOI: https://doi.org/10.15407/fz56.05.077

Abstract

Diameter, the surface area of lymphocytes and their nuclea as well as the reserve potential and regulatory properties of lymphocytes membranes in control rats, in rats with experi­mental diabetes mellitus before and after administration of L-arginine and aminoguanidine were investigated. Significant difference in size and the membrane fund of lymphocytes in animals with experimental diabetes mellitus was detected. In control lymphocytes, the membrane fund was 70% while dur­ing diabetes mellitus it was 40%. Such a difference might be one of the reasons of changes in properties and functional state of lymphocytes in diabetes. Administration of L-arginine and aminoguanidine to diabetic animals caused positive effect: the volume of lymphocytes diminished and the regulatory membrane properties of these cells became better.

Keywords: lymphocytes, experimental diabetes mellitus,L-arginine, aminoguanidine.

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