Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(5): 45-48


Cytokine spectrum of blood serum during inflammatory processes in the abdominal cavity

Lapovets' NIe

    Danylo Halyckyi National Medical University, Lviv, Ukraine
DOI: https://doi.org/10.15407/fz56.05.045

Abstract

The levels of cytokines (IL-1b, IL-6, TNF-a, IL-2, IL-10) in patients with phlegmonous appendicitis and abdominal tuber­culoses were studied. It is established that the level of cytokines IL-1b, IL-6, TNF-a considerably increases in patients with acute inflammatory process (phlegmonous appendicitis) and the level of interleukines IL-2, IL-10 considerably increases in patients with chronic inflammatory process (abdominal tuberculoses). Such parity of the cytokines levels can serve as a marker for differential diagnostics of acute and chronic inflammatory processes in abdominal cavity.

Keywords: cytokines, acute inflammatory process, abdomi-nal tuberculosis, immuno-diagnostics.

References

  1. Gumen A.V., Shanin S.N., Kozinets I.A. Tsitotoksicheskaya aktivnost' natural'nih killernih kletok selezenki kris pri stresse i ee korrektsiya korotkimi immunomoduliruyushchimi peptidami . Tsitokini i vospalenie. 2006. 5, N 2. S.37-41.
  2.  
  3. Zhidovinov A.A., Zurnadzh'yants V.A., Zhidovinov G.I. Znachenie laboratornih markerov endotoksikoza i tsitokinovogo profilya v diagnostike i effektiv­nosti lecheniya oslozhnennih form ostrogo holetsis­tita .Tsitokini i vospalenie. S.27-33.
  4.  
  5. Zinchuk A.N., Gerasun V.A., Shevchenko L.Yu. Sluchai abdominal'nogo tuberkuleza: slozhnosti diagnos­tiki . Problemi tuberkuleza. 2002. N 8. S.56-57.
  6.  
  7. Ketlinskii S.A., Simbirtsev A.S., Vorob'ev A.A. Endogennie immunomodulyatori. SPb:Gippokrat, 1992. 256 s.
  8.  
  9. Martinyuk I.I., Dasho Yu.A., Kiselik I.O. Abdominal'nii tuberkul'oz: mozhlivosti diagnostiki . Prakt. meditsina. 2003. IX, N 5. S.130-132.
  10.  
  11. Dinarello C.A. Biologic basis for interleukin-1 in disease . Blood. 1996. 6. P. 2095-2147. CrossRef PubMed
  12.  
  13. Fantuzzi G., Faggioni R., Sironi M. Defective inflammatory response and cytokine syntesis in IL-1p deficient mice . Cytokine. 1995. 7. P.608-615.
  14.  
  15. Hirano T., Matsuda T., Turner M. Excessive production of interleukin 6. B cell stimulatory factor-2 in rheumatoid arthritis . Eur. J. Immunol. 1988. 18. P.1797-1801. CrossRef PubMed
  16.  
  17. J.Talreja, A.Bhatnagar , S.Jindal. Influence of Mycobacterium tuberculosis on differential activation of helper T-cells . Clinic. and Exp. Immunol. 2003. 131, Issue 2. P.292-298. CrossRef PubMed PubMedCentral
  18.  
  19. Kudo C, Araki A., Matsushima K. Inhibition of IL-8-induced W3. 25+ (CD4+) T lymphocyte recruitment into subcutaneous tissues of rats by selective deple­tion of in vivo neutrophils with a monoclonal antibody . J.Immunol. 1991. P.147:2196-2201.
  20.  
  21. Rook G., Taverne J., Leveton C. The role of gamma-interferon, vitamin D3 metabolites and tumor necrosis factor in the pathogenesis of tuberculosis . Immuno­logy. 1987. 62, N 2. P. 229-234.
  22.  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.