Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(5): 23-33

Correlations of hippocampal theta-rhythm frequency changes with the signal characteristics of acoustic stimulation, latent periods and duration of conditioned reflectory movements in rats

Tal'nov AM

    O.O. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kyiv, Ukraine


The hippocampal theta rhythm was studied during an adap­tive behaviour elaboration (a receiving of drinking reward in response on a specific audio stimulus) in freely moving water deprived rats. It was revealed that a right behavioral response (a drinking tank visit) in conditions of discrimination of two sound stimuli emerged only in case of the theta rhythm fre­quency increase in response on the positive conditional stimu­lus. Although this increase occurred only in response to posi­tive signal it was also linked with the differentiation process -the theta rhythm frequency increase became significant when animals started to recognize positive and negative conditional stimuli. The detailed analysis revealed the detected theta rhythm frequency increase consisted of two waves. One of them was connected with the positive conditional stimulus presentation moment. The other one was connected with the time of ap­pearance and duration of movement to drinking tank after positive conditional stimulus presentation (right behavioral answers) as well as after negative conditional stimulus (wrong answers). At the same time the frequency was significantly higher during right behavioral answers comparing with wrong ones. It is concluded that the theta rhythm frequency increased during the sensory information analysis when it was needed to choose a signal leading to reinforcement and to exit from the state of the internal inhibition. On the other hand the fre­quency increased during the purposive movements.

Keywords: hippocamp, ?-rhythm, conditioned retlex.


  1. Melikov E.M. Funktsional'naya differentsiatsiya i-ritma gippokampa u koshek . Zhurn. vissh. nerv. deyatel'nosti. 1985. 35, N 3. S. 457-464. CrossRef  
  2. Pavlova I.V., Vanetsian G.L. Aktivnost' neironov neokorteksa i gippokampa krolikov pri orienti­rovochno-issledovatel'skom povedenii i zamiranii . Ros. fiziol. zhurn. im. I.M. Sechenova. 2006. 92, N 11. S. 1273-1284.
  4. Preobrazhenskaya L.A. Gippokampal'nii i-ritm i dvigatel'naya aktivnost' . Zhurn. vissh. nerv. deyatel'nosti. 1974. 24, N 1. S. 227-235.
  6. Fedotova I.R. Visokochastotnaya komponenta gippo-kampal'noi tata-aktivnosti . Zhurn. vissh. nerv. deyatel'nosti. 2003. 53, N 1. S. 70-80.
  8. Bland B.H. The physiology and pharmacology of the hippocampal formation theta rhythms . Prog. Neurobiol. 1986. 26. P. 1-54. CrossRef  
  9. Bland B.H., Colom L.V. Extrinsic and intrinsic proper­ties underlying oscillation and synchrony in limbic cortex . Prog. Neurobiol. 1993. 41. P. 157-208. CrossRef  
  10. Bland B.H, Jackson J., Derrie-Gillespie D. et al. Am­plitude, frequency, and phase analysis of hippocam­pal theta during sensorimotor processing in a jump avoidance task . Hippocampus. 2006. 16, N 8. P. 673-681. CrossRef PubMed
  12. Buzsaki G. Theta oscillations in the hippocampus . Neuron. 2002. 33. P. 1-16. CrossRef  
  13. Buzs6ki G., Haubenreiser J., Grasty6n E. et al. Hip­pocampal slow wave activity during appetitive and aversive conditioning in the cat . Electroencephalogr.Clin. Neurophysiol. 1981. 51, N 3. P.276-290. CrossRef  
  14. Deadwyler S., West M., Lynch G. Activity of dentate granule cells during learning: differentiation of perforant path input . Brain Res. 1979. 169. P. 29-43. CrossRef  
  15. Douglas R.J. The hippocampus and behavior . Psychol. Bull. 1967. 67, N 6. P. 416-422. CrossRef PubMed
  17. Goupillaud P., Grossmann A., Morlet J. Cycle-Octave and Related Transforms in Seismic Signal Analysis . Geoexploration. 1984-1985. 23. P. 85-102. CrossRef  
  18. Grastyan E., Liss6k K., Madar6sz J., Danhoffer H. Hippocampal electrical activity during the develop­ment of conditioned reflexes . EEG and Clin. Neurophysiol. 1959. 11, N 3. P.409-430. CrossRef  
  19. Jeewajee A., Lever C, Burton S. et al. Environmental novelty is signaled by reduction of the hippocampal theta frequency . Hippocampus. 2008. 18, N 4. P. 340-348. CrossRef PubMed PubMedCentral
  21. Huxter J., Burgess N., O'Keefe J. Independent rate and temporal coding in hippocampal pyramidal cells . Nature. 2003. 425. P. 828-832. CrossRef PubMed PubMedCentral
  23. Kocsis B., Bragin A., Buzsaki G. Interdependence of multiple theta generators in the hippocampus: a par­tial coherence analysis . J. Neurosci. 1999. 19. P. 6200-6212. CrossRef PubMed PubMedCentral
  25. Leung L.S. Pharmacology of theta phase shift in the hippocampal CA1 region of freely moving rats . Electroencephalogr. Clin. Neurol. 1984. 58. P.457-466. CrossRef  
  26. Leung L.W. Model of gradual phase shift of theta rhythm in the rat . J. Neurophysiol. 1984. 52. P. 1051-1065. CrossRef PubMed
  28. Lisman J.E., Idiart M.A. Storage of 7 *2 short-term memories in oscillatory subcycles . Science. 1995. 267. P. 1512-1515. CrossRef PubMed
  30. Lissak K., Grastyan E., Csanaky A. et al. A study of hippocampal function in the waking and sleeping animal with chronically implanted electrodes . Acta Physiol. Pharmacol. Neerl. 1957. 6. P. 451-459.
  32. Oddie S.D., Bland B.H. Hippocampal formation theta activity and movement selection . Neurosci. Biobehav. Rev. 1998. 22, N 2. P. 221-231. CrossRef  
  33. O'Keefe J., Recce M.L. Phase relationship between hippocampal place units and the EEG theta rhythm . Hippocampus 1993. 3. P. 317-330. CrossRef PubMed
  35. Olvera-Cortfis E. , Guevara M.A., Gonz6lez-Burgos I. Increase of the hippocampal theta activity in the Morris water maze reflects learning rather than motor activity . Brain Res. Bull. 2004. 62, N 5. P.379-384. CrossRef PubMed
  37. Pribram K.H. The limbic system, efferent control of neural inhibition and behavior . Progr. Brain Res. 1967. 27. P. 318-336. CrossRef  
  38. Shin J., Talnov A.A single trial analysis of hippocam­pal theta frequency during nonsteady wheel running in rats . Brain Res. 2001. 897, N 1-2. P.217-221. CrossRef  
  39. Skaggs W.E., McNaughton B.L., Wilson M.A., Barnes CA. Theta phase precession in hippocampal neuronal populations and the compression of temporal se­quences . Hippocampus. 1996. 6. P. 149-172. CrossRef  
  40. Talnov A. N., Quian Quiroga R., Meier M. et al. Entorhinal inputs to dentate gyrus are activated mainly by conditioned events with long time intervals . Ibid. 2003. 13, N 6. P. 755-765. CrossRef PubMed
  42. Tesche CD., Karhu J. Theta oscillations index human hippocampal activation during a working memory task . Proc. Natl. Acad. Sci. USA. 2000. 97, N 2. P.919-924. CrossRef PubMed PubMedCentral
  44. Torrence C, Compo G.P. A practical guide to wavelet analysis . Bull. Amer. Meteorol. Soc. 1998. 79. P. 61-78. CrossRef  
  45. Vanderwolf C.H. Hippocampal electrical activity and voluntary movement in the rat . Electroencephalogr. Clin. Neurophysiol. 1969. P. 407-418. CrossRef  
  46. Vertes R.P., Hoover W.B., Viana Di Prisco G. Theta rhythm of the hippocampus: subcortical control and functional significance . Behav. Cogn. Neurosci. Rev. 2004. 3. P. 173-200. CrossRef PubMed
  48. Wallenstein G.V., Hasselmo M.E. GABAergic modu­lation of hippocampal population activity: sequence learning, place field development, and the phase pre­cession effect . J. Neurophysiol. 1997. 78. P. 393-408. CrossRef PubMed
  50. Wilson M.A., McNaughton B.L. Dynamics of the hippocampal ensemble code for space . Science. 1993. 261, N 5124. P. 1055-1058. CrossRef PubMed
  52. Wyble B.P., Hyman J.M., Rossi CA., Hasselmo M.E. Analysis of theta power in hippocampal EEG during bar pressing and running behavior in rats during dis­tinct behavioral contexts . Hippocampus. 2004. 14,N 5. P.662-674. CrossRef PubMed

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.