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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(4): 130-138


Alteration of calcium signaling as one of the mechanisms of Alzheimer's disease and diabetic polyneuropathy

Kostiuk OP, Korol' TIu, Korol' SV, Romanenko SV, Pinchenko VO, Kostiuk PH

    O.O.Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz56.04.130

Abstract

This review is devoted to the action of amyloid-b peptide on the functional activity of intracellular and plasmalemmal calcium-regulated structures in cultured hyppocampal neurons: mitochondria and voltage-gated calcium channels. A comparative analysis of relative changes of plasmalemmal structures in such neurodegenerative diseases as Alzheimer’s illness and diabetic neuropathy has been made.

Keywords: mitochondrion, Alzheimer’s disease, diabetic neuropathy, neurodegenerative disease, neurons, hippocampus, plasmalemal calcium channels, calcium.

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