The pathways of taurine influences on gastric secretion
Hrinchenko OA, Ianchuk PI
National Taras Shevchenko University of Kyiv, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz56.04.111
Abstract
In chronic experiments with dogs with gastric fistulas the influence of amino acid taurine on the gastric secretion was investigated. We showed that taurine did not cause acid gastric secretion out of digestion, but increased the gastric secretion stimulated by histamine, increased the contents of gastric acid and pepsine in gastric secretes. When administered either 15 minutes or two hours prior histamine injection, taurin affected the Na+ and K+ concentrations in gastric juice. The greatest changes in the basic indices of gastric secretion were observed 14 hours after administration of taurin. In these experiments the contents of total proteins and components of adenile system in gastric secretes was increased also. Blockade of cholinoreceptors by atropine, benzohexonium and IEM-1678 decreased the effects of taurine on gastric secretion stimulated by histamine. Blockade of a-adrenoreceptors by phentola-mine did not prevent the taurine-induced effects on histamine-stimulated gastric secretion. It is established that under conditions of the blockade of b-adrenoreceptors by obsidane, taurine does not manifest entirely its potentiating influence on the gastric secretion stimulating by histamine. The data obtained indicate that taurine affects gastric secretion stimulated by histamine and realization of this effect occurs through M-and N-cholino- and b-adrenoreceptors.
Keywords:
taurine, gastric secretion, amino acids, cholinoreceptors, adrenoreceptors, nervous system.
References
- Gurevich B.C. Taurin i funktsiya vozbudimih kletok. L.: Nauka. 1986. 112 s.
- Elizarova E.P., Hodzhakuliev B.G., Zavopovskaya L.I., Chernogubova E.V. Farmakokinetika taurina . Kardiologiya. 1995. 34, N 4. C.69-70.
- Zvyagintseva T.V., Kirichok L.T., Kratenko G.S. Korektsiya taurinom stanu TsNS, nadnirnikovih zaloz ta fagotsitarnoi aktivnosti pri eksperimental'nomu stresi . Farmakologiya ta likar. toksikologiya. 2008. N 56 (67). S.58-63.
- Nefyodov L.I., Uglyanitsa K.N., Soldatov B.C. i dr. Mehanizmi regulyatsii metabolicheskogo balansa: rezul'tati i perspektivi primeneniya aminokislot i ih kompozitsii v kachestve universal'nih biologicheski aktivnih prirodnih regulyatorov napravlennogo deistviya i effektivnih lekarstvennih preparatov . Vestsi HAH Belarusi (ser. biol. nauk). 1998. N 4. C.62-70.
- Sheibak L.N., Nefyodov L.I., Sheibak M.P. Znachenie taurina dlya rastushchego organizma . Ros. vestn. perinatologii i pediatrii. 1995. 40, N 5. C.48-52.
- Barkhatova V.P., Panteleeva E.A., Alferova V.P. et al. Neurotransmission mechanism of movement disorders in multiple sclerosis . Zh. Nevrol. Psikhiatr. Im. S.S.Korsakova. 2007. 107, N 2. P.43-48.
- Beetsch J.W., Olson J.E. Taurine synthesis and cysteine metabolism in cultured rat astrocytes: effects of hyperosmotic exposure . AJP: Physiol. Cell Physiol. 1998. 274. P.C866-C874.
CrossRef
PubMed
- Chattipacorn S.C., McMahon L.L. Pharmacological Characterization of Glycine-Gated Chloride Currents Recorded in Rat Hippocampal Slices . J. Neurophysiol. 2002. 87,N 3. P.1515-1525.
CrossRef
PubMed
- Gavrovskaia L.K., Ryzhova O.V., Safonova A.F. et al. Effect of taurine and thioctacide on carbohydrate metabolism and the antioxidant system in rats with experimental diabetes . Eksp. Klin. Farmacol. 2008. 71,N 3. P.34-35.
- Han J., Bae J.H., Kim S.Y., Lee H.Y., Jang B.C., Lee I.K., Cho C.H., Lim J.G., Suh S.II, Kwon T.K., Park J.W., Ryu S.Y., Ho W.K., Earm Y.E., Song D.K. Taurine increases glucose sensitivity of UCP2-overexp-ressing v-cells by ameliorating mitochondrial metabolism . AJP: Endocrinol. Metab. 2004. 287. P.E1008-E1018.
CrossRef
PubMed
- Kim S.J., Ramesh C, Gupta H. Taurine-diabetes interaction: from involvement to protection . J. Biol. Regul. Homeost. Agents. 2007. 21, N 3-4. P.63-77.
- Lampson W.G., Kramier J.H., Schaffer S.W. Potentiation of the actions of insulin by maurine . Canad. J. Phisiol. Pharmacol. 1983. 61. P.57-63.
CrossRef
PubMed
- Levasseur S., Bado A., Laigneau J.P., Moizo L., Reyl-Desmars F., Lewin M.J. Characterization of a beta 3-adrenoceptor stimulating gastrin and somatostatin secretions in rat antrum . AJP: Gastrointest. and Liver Physiol. 1997. 272, Is.5. P.G1000-G1006.
CrossRef
PubMed
- Li F., Obrosova I.G., Abatan O., Tian D., Larkin D., Stuenkel E.L., Stevens M.J. Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats . AJP: Endocrinol. Metab. 2005. 288. P.E29-E36.
CrossRef
PubMed
- Motawi T.K., Abd Elgawad H.M., Shahin N.N. Modulation of indomethacin-induced gastric injury by spermine and taurine in rats . J. Biochem. Molec. Toxicol. 2007. 21,N 5. P.280-288.
CrossRef
PubMed
- Noulin J.F., Brochiero E., Lapointe J.Y, Laprade R. Two types of K channels at the basolateral membrane of proximal tubule: inhibitory effect of taurine . AJP: Renal Physiol. 1999. 277, N 2. P.F290-F297.
CrossRef
PubMed
- Oja S.S., Saransaari P. Pharmacology of taurine . Proc. West Pharmacol Soc. 2007. 50. P.8-15.
CrossRef
- Ortenblad N., Young J.F., Oksbjerg N., Nielsen J.H., Lambert I.H. Reactive oxygen species are important mediators of taurine release from skeletal muscle cells . AJP: Cell Physiol. 2003. 284, N .6. P.C1362-C1373.
CrossRef
PubMed
- Raufman J.P., Zimniak P., Bartoszko-Malik A. Litho-cholytaurine interacts with cholinergic receptors on dispersed chief cells from guinea pig stomach . J. Pharmacol. and Exp. Therap. 1998. 274, N 6. P.G997-G1004.
CrossRef
PubMed
- Waters E., Wang J.H., RedmondH.P., Wu O.D., Kay E., Bouchier-Hayer D. Role of taurine in preventing acetaminophen induced hepatic injuri in the rat . Gastrointestinal and Liver Physiol. 2001. 280. P.G127-1279.
CrossRef
PubMed
- Wettstein M., Peters-Regehr T., Kubitz R., Fischer R., Holneicher C, Monnighoff I., Haussinger D. Reliase of osmolites induced by phagocytosis and hormones in rat liver . J. Cell biol. online. 2000. 278. P.431-439.
CrossRef
PubMed
- Xie G., Drachenberg C, Yamada M. Cholinergic agonist-induced pepsinogen secretion from murine gastric chief cells is mediated by M1 and M3 muscarinic receptors . AGP: Gastrointest. Liver Physiol. 2005. 289,N 3. P.G521-G529.
CrossRef
PubMed
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