Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(4): 111-120


O.A.Grinchenko, P.I.Yanchuk

    National Taras Shevchenko University of Kyiv, Kyiv, Ukraine


In chronic experiments with dogs with gastric fistulas the in­fluence of amino acid taurine on the gastric secretion was investigated. We showed that taurine did not cause acid gastric secretion out of digestion, but increased the gastric secretion stimulated by histamine, increased the contents of gastric acid and pepsine in gastric secretes. When administered either 15 minutes or two hours prior histamine injection, taurin affected the Na+ and K+ concentrations in gastric juice. The greatest changes in the basic indices of gastric secretion were observed 14 hours after administration of taurin. In these experiments the contents of total proteins and components of adenile sys­tem in gastric secretes was increased also. Blockade of cholinoreceptors by atropine, benzohexonium and IEM-1678 decreased the effects of taurine on gastric secretion stimulated by histamine. Blockade of a-adrenoreceptors by phentola-mine did not prevent the taurine-induced effects on histamine-stimulated gastric secretion. It is established that under condi­tions of the blockade of b-adrenoreceptors by obsidane, tau­rine does not manifest entirely its potentiating influence on the gastric secretion stimulating by histamine. The data ob­tained indicate that taurine affects gastric secretion stimulated by histamine and realization of this effect occurs through M-and N-cholino- and b-adrenoreceptors.


  1. Гуревич B.C. Таурин и функция возбудимых клеток. -Л.: Наука. - 1986. - 112 с.
  2. Елизарова Е.П., Ходжакулиев Б.Г., Завоповская Л.И., Черногубова Е.В. Фармакокинетика таурина // Кардиология. - 1995. - 34, №4. - C.69-70.
  3. Звягінцева Т.В., Киричок Л.Т., Кратенко Г.С. Корекція таурином стану ЦНС, наднирникових залоз та фагоцитарної активності при експери­ментальному стресі // Фармакологія та лікар. токсикологія. - 2008. - №56 (67). - С.58-63.
  4. Нефёдов Л.И., Угляница К.Н., Солдатов B.C. и др. Механизмы регуляции метаболического баланса: результаты и перспективы применения аминокислот и их композиций в качестве универсальных биоло­гически активных природных регуляторов направ­ленного действия и эффективных лекарственных препаратов // Весцi HAH Беларусі (сер. биол. наук). -1998. -№4. - C.62-70.
  5. Шейбак Л.Н., Нефёдов Л.И., Шейбак М.П. Значение таурина для растущего организма // Рос. вестн. перинатологии и педиатрии. - 1995. - 40, №5. - C.48-52.
  6. Barkhatova V.P., Panteleeva E.A., Alferova V.P. et al. Neurotransmission mechanism of movement disorders in multiple sclerosis // Zh. Nevrol. Psikhiatr. Im. S.S.Korsakova. - 2007. - 107, №2. - P.43-48.
  7. Beetsch J.W., Olson J.E. Taurine synthesis and cysteine metabolism in cultured rat astrocytes: effects of hyperosmotic exposure // AJP: Physiol. Cell Physiol. -1998. – 274. - P.C866-C874.
  8. Chattipacorn S.C., McMahon L.L. Pharmacological Characterization of Glycine-Gated Chloride Currents Recorded in Rat Hippocampal Slices // J. Neurophysiol. -2002. - 87,№3. - P.1515-1525.
  9. 9. Gavrovskaia L.K., Ryzhova O.V., Safonova A.F. et al. Effect of taurine and thioctacide on carbohydrate me­tabolism and the antioxidant system in rats with ex­perimental diabetes // Eksp. Klin. Farmacol. - 2008. -71,№3. - P.34-35.
  10. 10. Han J., Bae J.H., Kim S.Y., Lee H.Y., Jang B.C., Lee I.K., Cho C.H., Lim J.G., Suh S.II, Kwon T.K., Park J.W., Ryu S.Y., Ho W.K., Earm Y.E., Song D.K. Tau­rine increases glucose sensitivity of UCP2-overexp-ressing в-cells by ameliorating mitochondrial metabo­lism // AJP: Endocrinol. Metab. - 2004. - 287. -P.E1008-E1018.
  11. Kim S.J., Ramesh C, Gupta H. Taurine-diabetes inter­action: from involvement to protection // J. Biol. Regul. Homeost. Agents. - 2007. - 21, №3-4. - P.63-77.
  12. Lampson W.G., Kramier J.H., Schaffer S.W. Potentia­tion of the actions of insulin by maurine // Canad. J. Phisiol. Pharmacol. - 1983. - 61. - P.57-63.
  13. Levasseur S., Bado A., Laigneau J.P., Moizo L., Reyl-Desmars F., Lewin M.J. Characterization of a beta 3-adrenoceptor stimulating gastrin and somatostatin se­cretions in rat antrum // AJP: Gastrointest. and Liver Physiol. - 1997. - 272, Is.5. - P.G1000-G1006.
  14. Li F., Obrosova I.G., Abatan O., Tian D., Larkin D., Stuenkel E.L., Stevens M.J. Taurine replacement at­tenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats // AJP: Endocrinol. Metab. - 2005. - 288. - P.E29-E36.
  15. Motawi T.K., Abd Elgawad H.M., Shahin N.N. Modu­lation of indomethacin-induced gastric injury by sper­mine and taurine in rats // J. Biochem. Molec. Toxicol. -2007. - 21,№5. - P.280-288.
  16. Noulin J.F., Brochiero E., Lapointe J.Y, Laprade R. Two types of K channels at the basolateral membrane of proximal tubule: inhibitory effect of taurine // AJP: Renal Physiol. - 1999. - 277, №2. - P.F290-F297.
  17. Oja S.S., Saransaari P. Pharmacology of taurine // Proc. West Pharmacol Soc. - 2007. - 50. - P.8-15.
  18. Ortenblad N., Young J.F., Oksbjerg N., Nielsen J.H., Lambert I.H. Reactive oxygen species are important me­diators of taurine release from skeletal muscle cells // AJP: Cell Physiol. - 2003. - 284, №.6. - P.C1362-C1373.
  19. 19. Raufman J.P., Zimniak P., Bartoszko-Malik A. Litho-cholytaurine interacts with cholinergic receptors on dispersed chief cells from guinea pig stomach // J. Pharmacol. and Exp. Therap. - 1998. - 274, №6. -P.G997-G1004.
  20. 20. Waters E., Wang J.H., RedmondH.P., Wu O.D., Kay E., Bouchier-Hayer D. Role of taurine in preventing acetaminophen - induced hepatic injuri in the rat // Gastrointestinal and Liver Physiol. - 2001. - 280. -P.G127-1279.
  21. Wettstein M., Peters-Regehr T., Kubitz R., Fischer R., Holneicher C, Monnighoff I., Haussinger D. Reliase of osmolites induced by phagocytosis and hormones in rat liver // J. Cell biol. online. - 2000. - 278. -P.431-439.
  22. Xie G., Drachenberg C, Yamada M. Cholinergic ago­nist-induced pepsinogen secretion from murine gastric chief cells is mediated by M1 and M3 muscarinic receptors // AGP: Gastrointest. Liver Physiol. - 2005. -289,№3. - P.G521-G529.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.