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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(4): 111-120


THE PATHWAYS OF TAURINE INFLUENCES ON GASTRIC SECRETION

O.A.Grinchenko, P.I.Yanchuk

    National Taras Shevchenko University of Kyiv, Kyiv, Ukraine


Abstract

In chronic experiments with dogs with gastric fistulas the in­fluence of amino acid taurine on the gastric secretion was investigated. We showed that taurine did not cause acid gastric secretion out of digestion, but increased the gastric secretion stimulated by histamine, increased the contents of gastric acid and pepsine in gastric secretes. When administered either 15 minutes or two hours prior histamine injection, taurin affected the Na+ and K+ concentrations in gastric juice. The greatest changes in the basic indices of gastric secretion were observed 14 hours after administration of taurin. In these experiments the contents of total proteins and components of adenile sys­tem in gastric secretes was increased also. Blockade of cholinoreceptors by atropine, benzohexonium and IEM-1678 decreased the effects of taurine on gastric secretion stimulated by histamine. Blockade of a-adrenoreceptors by phentola-mine did not prevent the taurine-induced effects on histamine-stimulated gastric secretion. It is established that under condi­tions of the blockade of b-adrenoreceptors by obsidane, tau­rine does not manifest entirely its potentiating influence on the gastric secretion stimulating by histamine. The data ob­tained indicate that taurine affects gastric secretion stimulated by histamine and realization of this effect occurs through M-and N-cholino- and b-adrenoreceptors.

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