Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(4): 102-110

Effect of long-term monosodium glutamate administration on structure and functional state of the stomach and body weight in rats

Falalieieva TM, Kukhars'kyĭ VM, Berehova TV

    Kyiv National Taras Shevchenko University, Ukraine
DOI: https://doi.org/10.15407/fz56.04.102

Abstract

The influence of prolonged administration of monosodium glutamate (MSG) on basal gastric acid secretion, body weight and gastric mucosa in rats was studied. We found that 10 -, 20 -, 30-days feeding by MSG in doses 15 to 30 mg/kg (equiva­lent to 1 and 2 g/person) leads to erosive and ulcerative lesions of the gastric mucosa and an increased secretion of hydrochlo­ric acid and an increased body weight. It is concluded that the stimulating effect of MSG on the basal secretion of hydro­chloric acid in the stomach may be implicated in the pathogen­esis of a number of acid-dependent diseases. An excessive consumption of MSG can cause a «Chinese Restaurant Syn­drome» and gastritis, gastric and duodenal ulcers. Therefore, the maximum dose of MSG should be reconsidered taking into account its influence on the secretory capacity of the stomach. We also conclude that prolonged, excessive and systemic consumption of MSG causes obesity.

Keywords: Monosodium glutamate, gastric acid secretion, obesity, gastric ulcers.

Full text: (PDF, in Ukrainian)

References

  1. Buldakov A.S. Pishchevie dobavki: Spravochnik. SPb.: It, 1996. 240 s.
    2.  
  2. Glants S. Mediko-biologicheskaya statistika. M.Lraktika, 1998. 459 s.
    3.  
  3. Groisman S.D., Gubkin V.A., Beregovaya T.V. Poluavtomaticheskaya elektrotitrometricheskaya ustanovka dlya titrovaniya zheludochnogo soka . Lab. delo. 1988. N 9. C. 66-67.
    4.  
  4. Mal'tsev V.I., Belousov D.Yu. Eticheskaya otsenka metodik provedeniya issledovanii . Ezhenedel'nik Apteka. 2001. N 34. S. 35.
    5.  
  5. Pokrovskii V.I. Biomeditsinskaya etika. M., 1997. 224 s.
    6.  
  6. Smolyar V.I. Problemi vikoristannya harchovih dobavok v Ukraini. V kn.: Tezi don. Mizhnar. nauk. tehn. konferentsii NUHT. K., 1998. S 53.
    7.  
  7. Falalieieva T.M., Beregova T.V., Shtanova L.Ya. Glutamatni retseptori ta ih rol' u regulyatsii sekretsii kisloti v shlunku (oglyad literaturi) . Eksperim. ta klip. fiziologiya i biohimiya. 2007. 2, N 37. S 53-59.
    8.  
  8. Falalieieva T.M., Dzyubenko N.V., Suhodolya A.I., Beregova T.V. Doslidzhennya roli glutamatnih retseptoriv NMDA-tipu v regulyatsii bazal'noi ta stimul'ovanoi insulinom shlunkovoi sekretsii u shchuriv . Visnik Kiiv. nats. un-tu im. Tarasa Shevchenka. Problemi regulyatsii fiziol. funktsii. 2004, N 9. S 10-11.
    9.  
  9. Allen D.H., Delohery J., Baker G. Monosodium L-glutamate-induced asthma . J. Allergy and Clin. Im­munol. 1987. 80. P. 530-537. CrossRef  
  10. Bazzano G., D'Elia J.A., Olson R.E. Monosodium glutamate: feeding of large amounts in man and gerbils . Science. 1970. 169. P. 1208-1209. CrossRef PubMed
    11.  
  11. Bray G.A. Syndromes of hypothalamic obesity in man . Pediatr Ann. 1984. 13. P. 525-536.
    12.  
  12. Cao Y., Song G. Purinergic modulation of respiration via medullary raphe nuclei in rats . Respir. Physiol. & Neurobiol. 2007. 155, N 2. P. 114-120. CrossRef PubMed
    13.  
  13. Cutler R.G. Peroxide-producing potential of tissues: inverse correlation with longevity of mammalian species. . Proc. Nat. Acad. Sci. USA. 1985. 82, N 14. P.4798-4802. CrossRef PubMed PubMedCentral
    14.  
  14. Davies N.E. Chinese-restaurant syndrome . N. Engl. J. Med. 1968. 278, N 20. P. 1124. CrossRef  
  15. Falalyeyeva T., Shtanova L., Dryvecka T., Beregova T. The role of ionotropic glutamate receptors ampa. kainate type in the mechanism of formation of basal gastric acid secretion in rats . Annales universitatis Mariae Curie-Sklodowska. Lublin-Polonia, Sectio DDD. 2007. 20,N .1. P.107-111.
    16.  
  16. Freeman M. Reconsidering the effects of monosodium glutamate: a literature review . J Amer. Acad. Nurse. Pract. 2006. 18, N 10. P.482-486. CrossRef PubMed
    17.  
  17. Garcna O.J.C., Moyano C, Fonseca J.L., Bellido J. The Chinese restaurant syndrome . Med. Clin. (Barc). 1996. 107, N 13. P. 518.
    18.  
  18. Geha R., Beiser A., Ren C. Review of alleged reactions to monosodium glutamate and outcome of a multicenter double-blind placebo-controlled study . J. Nutr. 2000. 130. P. 1058-1062. CrossRef PubMed
    19.  
  19. Ghadimi H., Kumar S., Abaci F. Studies on monosodium glutamate ingestion. I. Biochemical explanation of the Chinese restaurant syndrome . Biochem. Med. 1971. 5. P. 447-456. CrossRef  
  20. Ghosh M.H., Shild H.O. Continuous recording of acid gastric secretion in the rat . Brit. J. Pharm. Chemother. 1958. 13. P.54-61. CrossRef PubMed PubMedCentral
    21.  
  21. Gordon ME. Chinese-restaurant syndrome . N. Engl. J. Med. 1968. 278, N 20. P. 1123-1124. CrossRef  
  22. Gore M.E., Salmon P.R. Chinese restaurant syndrome: fact or fiction? . Lancet. 1980. 1. P. 251-252. CrossRef  
  23. He K., Zhao L., Daviglus M.L. Association of monosodium glutamate intake with overweight in Chinese adults: the INTERMAP Study . Obesity. 2008. 16, N 8. P. 1875-1880. CrossRef PubMed PubMedCentral
    24.  
  24. Hermanussen M., Tresguerres J.A. Does high glutamate intake cause obesity? . J. Pediatr. Endocrin. Metab. 2003. 16, N 7. 965-968.25. Kandall S.R. Chinese-restaurant syndrome . N. Engl. J. Med. 1968. 278, N 20. P. 1123. CrossRef  
  25. Kwok R.H.M Chinese-restaurant syndrome . Ibid. 1968. 278, N 20. P. 796. CrossRef PubMed
    26.  
  26. McCaghren T.J. Chinese-restaurant syndrome . Ibid. 1968. 278, N 20. P. 1123. CrossRef  
  27. Monno A. Extracellular glutamate levels in the hypo­thalamus and hippocampus of rats after acute or chronic oral intake of monosodium glutamate . Neurosci Lett. 1995. 193, N 1. P. 45-48. CrossRef  
  28. Morselli P.L., Garattini S. Monosodium glutamate and the Chinese restaurant syndrome . Nature (Lond.). 1970. 227. P. 611-612. CrossRef PubMed
    29.  
  29. Ozawa S., Kamiya H., Tsuzuki K. Glutamate receptors in the mammalian central nervous system . Prog. Neurobiol. 1998. 54, N 5. P. 581-618. CrossRef  
  30. Raliou M., Wiencis A., Pillias A.M. et al. Non-synonymous single nucleotide polymorphisms in human tas1r1, tas1r3, and mGluR1 and individual taste sensi­tivity to glutamate . Amer. J. Clin. Nutr. 2009. 90, N 3. P. 789-799. CrossRef PubMed
    31.  
  31. Rosenblum I., Bradley J.D., Coulston, F. Single and double blind studies with oral monosodium glutamate in man . Toxicol. Appl. Pharmacol. 1971. 18. P. 367-373. CrossRef  
  32. Schaumburg H. Chinese-restaurant syndrome . N. Engl. J. Med. 1968. 278, N 20. P. 1122. CrossRef  
  33. Schaumburg, H.H., Byck R., Gerstl R., Mashman J.H. Monosodium L-glutamate: its pharmacology and role in the Chinese restaurant syndrome . Science (Washington, DC). 1969. 163. P. 826-828. CrossRef PubMed
    34.  
  34. Tarasoff L., Kelly M.F. Monosodium L-glutamate: A double-blind study and review . Food and Chem. Toxicol. 1993. 31. P. 1019-1035. CrossRef  
  35. Tsai L.H., Lee Y.J., Wu J.Y. Effect of excitatory amino acid neurotransmitters on acid secretion in the rat stom­ach . J. Biomed. Sci. 1999. 6. P. 36-44. CrossRef PubMed
    36.  
  36. Tsai L.H., Tsai W., Wu J.Y. Effect of L-glutamic acid on acid secretion and immunohistochemical localization of glutamatergic neurons in the rat stomach . J. Neurosci. Res. 1994. 38. P. 188-195. CrossRef PubMed
    37.  
  37. Watkins J.C, Evans R.H. Excitatory amino acid transmit­ters . Annu. Rev. Pharmacol. Toxicol. 1981. 21. P. 165-204. CrossRef PubMed
    38.  
  38. Watkins J.C, Jane D.E. The glutamate story . Brit. J. Pharmacol. 2006. 147 (Suppl. 1). P. 100-108. CrossRef PubMed PubMedCentral
    39.  
  39. Williams A.N., Woessner K.M. Monosodium glutamate 'allergy': menace or myth? . Clin. Exp. Allergy. 2009. 39, N 5. P. 640-646. CrossRef PubMed
    40.  
  40. Yang W.H., Drouin M.A., Herbert M., Mao Y, Karsh J. The monosodium glutamate symptom complex: assessment in a double-blind, placebo-controlled, randomized study . J. Allergy Clin. Immunol. 1997. 99. P. 757-762. CrossRef  
  41. Zautcke J.L., Schwartz J.A., Mueller E.J. Chinese restaurant syndrome: a review . Ann. Emerg. Med. 1986. 15, N 10. P. 1210-1230. CrossRef

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2022.