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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(4): 102-110


Effect of long-term monosodium glutamate administration on structure and functional state of the stomach and body weight in rats

Falalieieva TM, Kukhars'kyĭ VM, Berehova TV

    Kyiv National Taras Shevchenko University, Ukraine
DOI: https://doi.org/10.15407/fz56.04.102

Abstract

The influence of prolonged administration of monosodium glutamate (MSG) on basal gastric acid secretion, body weight and gastric mucosa in rats was studied. We found that 10 -, 20 -, 30-days feeding by MSG in doses 15 to 30 mg/kg (equiva­lent to 1 and 2 g/person) leads to erosive and ulcerative lesions of the gastric mucosa and an increased secretion of hydrochlo­ric acid and an increased body weight. It is concluded that the stimulating effect of MSG on the basal secretion of hydro­chloric acid in the stomach may be implicated in the pathogen­esis of a number of acid-dependent diseases. An excessive consumption of MSG can cause a «Chinese Restaurant Syn­drome» and gastritis, gastric and duodenal ulcers. Therefore, the maximum dose of MSG should be reconsidered taking into account its influence on the secretory capacity of the stomach. We also conclude that prolonged, excessive and systemic consumption of MSG causes obesity.

Keywords: Monosodium glutamate, gastric acid secretion, obesity, gastric ulcers.

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