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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(4): 96-101


The influence of an inhibitor of nf-kbactivation curcumin on theoogenesis and follicular cell deathin immune ovarian failure in mice

Т.Voznesenskaya1, Т. Bryzgina, V. Sukhina,N. Makogon, І. Аlexeyeva

    O.O.Bogomoletz Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv;Ukrainian Academy of Sciences, Kyiv, Ukraine


Abstract

In experiments on CBA mice, we studied the influence of an inhibitor of nuclear transcription factor kB activation curcumin, obtained from Curcuma longa, on the meiotic maturation of oocytes and apoptotic and necrotic death of follicular cells atimmune ovary failure induced by immunization of animals with allogenic ovarian extracts. NF-kB plays a pivotal role in the induction of genes encoding pro- inflammatory factors (cytokines, adhesion molecules, inducible NO- synthase and cyclooxygenase) and in regulation of cell proliferation and death. It has been shown that immunization of mice increased the death of follicular cells through an apoptotic and necrotic path­ways, which led to inflammatory response (according to blood leukogram and impairment the oocyte meiotic maturation at metaphase I and II). Intragastric administration of curcumin (Sigma, USA, 2mg of the mouse weight, four times a week during the period of immunization) reduced the number of the follicular cells died through apoptotic and especially necrotic pathway. Curcumin attenuated an inflammatory response and improved the meiotic maturation of oocytes impaired under experimental immune ovarian failure in mice.

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