Effect of NF-kappaB activation inhibitor curcumin on the oogenesis and follicular cell death in immune ovarian failure in mice
Voznesens'ka TIu, Bryzhina TM, Sukhina VS, Makohon NV, Aleksieieva IM
O.O.Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz56.04.096
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Abstract
In experiments on CBA mice, we studied the influence of an inhibitor of nuclear transcription factor kB activation curcumin, obtained from Curcuma longa, on the meiotic maturation of oocytes and apoptotic and necrotic death of follicular cells atimmune ovary failure induced by immunization of animals with allogenic ovarian extracts. NF-kB plays a pivotal role in the induction of genes encoding pro- inflammatory factors (cytokines, adhesion molecules, inducible NO- synthase and cyclooxygenase) and in regulation of cell proliferation and death. It has been shown that immunization of mice increased the death of follicular cells through an apoptotic and necrotic pathways, which led to inflammatory response (according to blood leukogram and impairment the oocyte meiotic maturation at metaphase I and II). Intragastric administration of curcumin (Sigma, USA, 2mg of the mouse weight, four times a week during the period of immunization) reduced the number of the follicular cells died through apoptotic and especially necrotic pathway. Curcumin attenuated an inflammatory response and improved the meiotic maturation of oocytes impaired under experimental immune ovarian failure in mice.
Keywords:
ovarium, immune ovary failure, meiotic maturation of oocytes, follicular cells, apoptosis, necrosis, curcumin
References
- Lakin G.F. Biometriya. M.: Vissh. shkola, 1980. 293 s.
- Makogon NV, Voznesenska T.Yu., Brizgin TM, Sukhina B.C., Grushka NG, Alekseeva I.M. Protective action of molsidomine in immune pathology of the ovaries of the mice . Fiziol zh. 2007. 53, N 5. p. 29-34.
- Ostanin A.A., Aizikovich B.I., Aizikovich I.V., Kozhin A.Yu, Chernih E.R. Rol' tsitokinov v regulyatsii reproduktivnoi funktsii . Byul. eksperim. biologii i meditsini. 2007. 143, N 1. S. 81-85.
CrossRef
PubMed
- Aggarwal S., Ichikawa H., Takada Y, Sandur S.K., Shishodia S., Aggarwal B. Curcumin (diferuloymethane) down regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of I kappa B alpha kinase and Akt activation . Mol. Pharmacol. 2006. 69,N 1. P. 195-206.
CrossRef
PubMed
- Bornstein S.R., Rutkowski H., Kreras J. Cytokines and steroidogenesis . Mol.Cell Endocrinol. 2004. 215, N 1-2. P. 135-141.
CrossRef
PubMed
- Bright J. Curcumin and autoimmune disease . Adv. Exp. Med. Biol. 2007. 595. P. 425-451.
CrossRef
PubMed
- Forges T., Monnier-Barbarino P., Faure G.C., Bene M.C. Autoimmunity and antigenic targets in ovarian pathology . Hum. Reprod. Update. 2004. 10. P. 163-175.
CrossRef
PubMed
- Hatcher H., Planalp R., Cho J. Torti F.M., Torti S.V. Curcumin: from ancient medicine to current clinical trials . Cell Mol. Life Sci. 2008. 65, N 11. P. 1631-1652.
CrossRef
PubMed PubMedCentral
- Hsu C.H., Cheng A.L. Clinical studies with curcumin . Adv. Exp. Med. Biol. 2007. 595. P. 471-480.
CrossRef
PubMed
- Kang B., Song Y, Kim K., Choe Y.K., Hwang S.Y, Kim T.S. Curcumin inhibits cytokine profile in CD 4+ T cells by suppressing interleukin-12 production in macrophages . Brit. J. Pharm. 1999. 128. P. 380-384.
CrossRef
PubMed PubMedCentral
- Kimura M., Haisa M., Uetsuka H., Takaoka O., Ohkawa T., Kawashima R., Yamatsuji T., Gundur M., Kaneda Y, Tanaka N., Naomoto Y TNF combined with IFN-a accelerates NF-kB mediated apoptosis through enhancement of Fas expression in colon cancer cells . Cell Death Differ. 2003. 10, N 6. P. 718-728.
CrossRef
PubMed
- Kiyoshi O., Ryosuke S. Multiple role of TNF super family member in corpus luteum function . Reprod. Biol. Endocrinol. 2003. 1. P. 95-105.
CrossRef
PubMed PubMedCentral
- Kurylovicz A., Nauman J. The role of nuclear factor kB in the development of autoimmune diseases: a link between genes and environment.Acta biochemica Polonica. 2008. 55,N 4.
- Luborsky J. Ovarian autoimmune disease and ovarian autoantibodies . J. Women's Health and Gender Based Medicine. 2002. 11. P. 585-599.
CrossRef
PubMed
- Maheshwari R.K., Singh A.K., Gaddipati J., Srimal R.C. Multiple biological activities of curcumin: A short review . Life Sciences- 2006. 78. P. 2081-2087.
CrossRef
PubMed
- Pandedkar T.D., Wadia P. Autoimmune disorders of the ovary . Ind. J.Exp.Biol. 1998. 36, N 5. P. 433-436.
- Reyes-Gordillo K., Segovia J., Shibayama M., Vergara P., Moreno M.G., Muriel P. Curcumin protects against acute liver damage in the rat by inhibiting NF-kB proinflammatory cytokines production and oxidative stress . Biochem. Biophys. Acta. 2007. 1770. P. 989-996.
CrossRef
PubMed
- Santoro N. Research on the mechanisms of premature ovarian failure . J. Gynecol. Investig. 2002. 8, N 1. P. 10-12.
- Shen H-M., Pervaiz S. TNF receptor superfamily induced cell death: redox dependent execution .
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