In experiments on CBA mice, we studied the influence of an inhibitor of nuclear transcription factor kB activation curcumin, obtained from Curcuma longa, on the meiotic maturation of oocytes and apoptotic and necrotic death of follicular cells atimmune ovary failure induced by immunization of animals with allogenic ovarian extracts. NF-kB plays a pivotal role in the induction of genes encoding pro- inflammatory factors (cytokines, adhesion molecules, inducible NO- synthase and cyclooxygenase) and in regulation of cell proliferation and death. It has been shown that immunization of mice increased the death of follicular cells through an apoptotic and necrotic path­ways, which led to inflammatory response (according to blood leukogram and impairment the oocyte meiotic maturation at metaphase I and II). Intragastric administration of curcumin (Sigma, USA, 2mg of the mouse weight, four times a week during the period of immunization) reduced the number of the follicular cells died through apoptotic and especially necrotic pathway. Curcumin attenuated an inflammatory response and improved the meiotic maturation of oocytes impaired under experimental immune ovarian failure in mice.