Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(3): 62-69


Effects of hypokinesia and hypoxiaon bone static electrogenesis

M.I. Levashov, S.L. Saphonov, P.V.Lakhin.

    O.O.Bogomoletz Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv


Abstract

It was studied the conformities to law of quasistatic electric potential (QSEP) distribution on the periosteal surface of 64 adult Vistar rats-males fresh exited femur and their changes after dosed hypokinesia and hypoxia influences. The maximal negative sizes of QSEP were incorporated in epiphyseal-meta-physeal departments and minimal - in the central part of bone diaphysis. Conformities to law of QSEP distribution on the periosteal surface fresh exited bone represented the physiol­ogy unevenness of metabolic processes intensity in the differ­ent bone departments. Reparative regeneration was accompa­nied with strengthening of electro-negativity of reparations and adjacent parts and changing of physiology character of QSEP distribution on the periosteal surface of the damaged bone. Hypokinesia disturbed of bone static electrogenesis. It was accompanied with diminishing of QSEP size especially in bone parts which had hight level of metabolism. Dosed an intermittent normobarical and hypobarical hypoxia activated of bone static electrogenesis. More considerably increasing of QSEP in old rats was obtained after the intermittent hypobarical hypoxia influences.

Keywords: bone, quasistatic electric potential, hypokinesia,hypoxia.

References

  1. Акимова Е.Л., Логинова Н.К. Электрогенез в челюстных костях и зубах и возможности его использования в практической стоматологии// Стоматология. - 1994. - №1. - С. 62-67.
  2. Березовський В.Я., Літовка І.Г., Чака О.Г., Лахін П.В. Фізіологічна стимуляція ремоделювання кісткової тканини//Фізіол. журн. - 2002. - 48, №2. -С.49.
  3. Бруско А.Т., Гайко Г.В. Функциональная перест-ройка костей и ее клиническое значение. - Луганск: ЛГМУ, 2005. - 212 с.4. Гончарова Л.Д., Тяжелов А.А., Лобанов Г.В. Концепция внутренних напряжений опорных структур и ее место в вопросах остеосинтеза // Травма. - 2008. - 9, №2. - С.227-232.
  4. Карлсон Б.М. Регенерация. - М.: Наука, 1986. -296 с.
  5. Левашов О.М., Березовский В.А., Левашов М.И, Сафонов С.Л. Влияние прерывистой нормоба-рической гипоксии на кислородный метаболизм и биофизические свойства кости при гипокинезии // Укр. мед. альманах. - 2007. - 10, №5. - С.105-109.
  6. Оганов B.C. Гипокинезия - фактор риска остеопо-роза//Остеопорозиостеопения. - 1998,№1. -С.13-17.
  7. Ткаченко С.С. Остеосинтез. –Л.: Медицина, 1987. -272 с.
  8. 9. Хан Т. Метаболические болезни костей /Эндокри­нология/ Ред. Н. Лавин, Пер. с англ. В. И. Кандрора при участии Э. А. Антуха, Т. Г. Горлиной под ред. А. В. Тимофеева. - М.: Практика, 1999. - Гл. 25. - С.455-478.
  9. 10. Burr D.B. The contribution of the organic matrix to bone’s material properties// Bone. - 2002. - 31, №1. -P.8-11.
  10. El-Lakkani A. Dielectric response of some biological tissues // Bioelectromagnetics. - 2001. - 22, №4. -P.272-279.
  11. Gabriel C. Dielectric properties of biological tissue: variation with age // Ibid. -2005, Suppl. 7. - C.12-18.
  12. Hastings G.W., Mahmud F.A. Electrical effects in bone// J. Biomech. Eng. - 1998. - 10, №6. - P.515-521.
  13. Kotha S.P., Guselsu N. Effect of bone mineral content on the tensile properties of cortical bone: experiments and theory // Ibid. - 2003. - 125, №6. - P.785-793.
  14. McDonald F. Electrical effects at the bone surface // Eur. J. Ortodontics. - 1993. - 15. - P.175-183.
  15. Fukada E., Yasuda I. On the piezoelectric effect of bone // J. Physiol. Society of Japan. - 1957. - №12. -P.1158-1162.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.