Signal function of potassium channels – clinical aspects
Magura IS, Magura OI, Dolga OV, Bogdanova NA, Ageev Sh, Pogorela NKh
O.O. Bogomoletz Instiute of Physiology National Academy of Science of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz56.03.019

Abstract
Potassium (K+) channels are the most diverse class of ion channels, and are important for regulating neuronal excitability and signaling activity in a variety of ways. They are major determinants of membrane excitability, influencing the resting potential of membranes, wave forms and frequencies of action potentials, and thresholds of excitation. Voltage-gated K+ cannels exist not as independent units merely responding to changes in transmembrane potential but as macromolecular complexes able to integrate a plethora of cellular signals that fine tune channel activities. There are a wide variety of therapeutic agents that are targeted to non-K+ channels, but result in unintended block of K+ channels. This K+ channel block can result in potentially serious and sometimes even fatal side effects.
Keywords:
K+ channels; cumulative inactivation; ancillary subunits; neuronal signaling; genetic diseases.
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