Signal function of potassium channels – clinical aspects
Magura IS, Magura OI, Dolga OV, Bogdanova NA, Ageev Sh, Pogorela NKh
O.O. Bogomoletz Instiute of Physiology National Academy of Science of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz56.03.019
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Abstract
Potassium (K+) channels are the most diverse class of ion channels, and are important for regulating neuronal excitability and signaling activity in a variety of ways. They are major determinants of membrane excitability, influencing the resting potential of membranes, wave forms and frequencies of action potentials, and thresholds of excitation. Voltage-gated K+ cannels exist not as independent units merely responding to changes in transmembrane potential but as macromolecular complexes able to integrate a plethora of cellular signals that fine tune channel activities. There are a wide variety of therapeutic agents that are targeted to non-K+ channels, but result in unintended block of K+ channels. This K+ channel block can result in potentially serious and sometimes even fatal side effects.
Keywords:
K+ channels; cumulative inactivation; ancillary subunits; neuronal signaling; genetic diseases.
References
- Magura IS, Dolga OV, Bogdanova NO Integrative function of nerve cells: the role of potassium channels . Fiziol zh. 2008. 54, N 5. P. 16-22.
- Aldrich R.W. Inactivation of voltage-gated delayed potassium current in molluscan neurons: a kinetic model . Biophys. J. 1981. 36. P. 519-532.
CrossRef
- Baukrowits T., Yellen G. Modulation of K current by frequency and external [K]: a tale of two inactivation mechanisms . Neuron. 1995. 15. P. 951-960.
CrossRef
- Bezanilla F. Ion channels: from conductance to-structure . Ibid. 2008. 60. P. 456-468.
CrossRef
PubMed
- Bett GCL., Rasmusson R.L. Modification of K channel drug interactions by ancillary subunits.J. Physiol. 2008. 586. 4. P. 929-950.
CrossRef
PubMed PubMedCentral
- Black D.L. Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology . Cell. 2000. 103. P. 367-370.
CrossRef
- Choe S. Potassium channel structures . Nat. Rev. Neurosci. 2002. 3 P. 115-121.
CrossRef
PubMed
- Consiglio J.F., Andalib P, Korn S.J. Influence of pore residues on permeation properties in the Kv2.1 potassium channel. Evidence for a selective functional interaction of K+ with the outer vestibule . J. Gen. Physiol. 2003. 2. P. 111-124.
CrossRef
PubMed PubMedCentral
- Crouzy S., Berneghe S., Roux B. Extracelluar blockade of K channels by TEA: results from molecular dynamics simulations of the KcsA channel . Ibid. 2001. 18. P. 207-217.
CrossRef
PubMed PubMedCentral
- Debanne D. Plasticity of neuronal excitability in vivo . J.Physiol. 2009. 587, N 13. P. 3057-3058.
CrossRef
PubMed PubMedCentral
- Doyle D.A., Cabral J.M., Pfuetzner R.A., Kuo A, Gulbis J.M., Cohen S.L., Chait B.T., MacKinnon R. The structure of the potassium channel: Molecular Basis of K+ conduction and selectivity . Science. 1998. 280. P. 69-77.
- Immke D, Korn S.J. Ion-ion interaction at the selectivity filter. Evidence from K+-dependent modulation of tetraethylammonium efficacy in Kv2.1 potassium channels . J. Gen. Physiol. 2000. 115. P. 509-518.
CrossRef
PubMed PubMedCentral
- Isom L.L., De Jongh K.S., Catterall W.A. Auxiliary subunits of voltage-gated ion channels . Neuron. 1994. 12. P. 1183-1194.
CrossRef
- Johnston D, Hoffman D.A., Magee J.C. Dendritic potassium channels in hippocampal pyramidal neurons . J. Physiol. 2000. 525, N 1. P. 75-81.
CrossRef
PubMed PubMedCentral
- Heginbotham L., MacKinnon R. The aromatic binding site for tetraethylammonium ion on potassium channels . Neuron. 1992. 8. P. 483-491. Oxford.
CrossRef
- Kostyuk P. 1998. Plasticity in nerve cell function. Clarendon Press, Oxford University Press. 1998. P. 228.
- Klemic K.G., Shieh C.C., Kirsch G.E., Jones S.W. Inactivation of Kv2.1 Potassium Channels . Biophys J. 74. P. 1779-1789.
CrossRef
- Klemic K.G., Kirsch G.E., Jones S.W. U-type inactivation of Kv3.1 and Shaker potassium channels . Biophys J. 81. P. 814-826.
CrossRef
- Ma M., Koester J. The role of K currents in frequency-dependent spike broadening in Aplysia R20 Neurons: a dynamic-clamp analysis . J. Neurosci. 1996. 16. P. 4089-4102.
CrossRef
PubMed PubMedCentral
- MacKinnon R. Potassium channels . FEBS Lett. 2003. 555. P. 62-65.
CrossRef
- MacKinnon R., Yellen. Mutation affecting TEA blockade and ion permeation in voltage-activated K channels . Science. 1990. 250. P. 276-279.
CrossRef
PubMed
- MacLean J.N., Zhang Y, Johnson B.R., Harris-Warrick R.M. Activity independent homeostasis in rhythmically active neurons . Neuron. 2003. 37. P. 109-120.
CrossRef
- Magura I.S., Krishtal O.A., Valeyev A.G. Behaviour of delayed current under long duration voltage clamp in snail neurons . Compar. Biochem. Physiol. 1971. 40A. P. 715- 722.
CrossRef
- Magura I.S., Kucher V.V., Boiko N.Y Voltage-operated potassium channels and mechanisms controlling their activity . Neurophysiology. 2004. 36. P. 285-292.
CrossRef
- Magura I.S., Zamekhovsky I.Z. Repetitive firing in molluscan giant neurons . Exp. Biol. 1973. 59. P. 767-780.
- Martens J.R., O'Connell K., Tamkun M., Targeting of ion channels to membrane microdomains: localization of K channels to lipid rafts . Trends Pharmacol. Sci. 2004v. 25. P. 16-21.
CrossRef
PubMed
- McDonald T.V., Li Y, Um S.Y Voltage gated potas-sium channels: regulation by accessory subunits . Neuroscientist. 2006. 12. P. 199-209.
CrossRef
PubMed
- Miller C. An overview of the potassium channel family . Genome Biol. 2000. I (4).- P.0004.1-0004.5.
CrossRef
PubMed PubMedCentral
- Narayanan R., Johnston D. The ascent of channels with memory . Neuron. 2008. 60. P. 735-738.
CrossRef
PubMed
- Papazian D.N. Potassium Channels: some assembly required . Ibid. 1999. 23. P. 7-10.
CrossRef
- Patil P.G., Brody D.L., Yue D.T. Preferential closed-state inactivation of neuronal calcium channels . Ibid. 1998. 20. P. 1027-1038.
CrossRef
- Spitzer N.C. New dimensions of neuronal plasticity . . Nat. Neuroscie. 1999. 2. P. 489-490.
CrossRef
PubMed
- Spruston P.J. Pyramidal neurons: dendritic structure and synaptic integration . Nat. Rev. Neurosci. 2008. 9. P. 206-221.
CrossRef
PubMed
- Thompson J., Begenisich T. External TEA block of shaker K+ channels is coupled to the movement of K ions within the selectivity filter . J. Gen. Physiol. 2003. 122. P. 239-246.
CrossRef
PubMed PubMedCentral
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