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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(3): 19-24


Signal function of potassium channels – clinical aspects

I.S. Magura, O.I. Magura, O.V. Dolga, N.A. Bogdanova, Sh. Ageev, N.Kh. Pogorela

    O.O. Bogomoletz Instiute of Physiology National Academyof Science of Ukraine, Kyiv, Ukraine


Abstract

Potassium (K+) channels are the most diverse class of ion channels, and are important for regulating neuronal excitability and signaling activity in a variety of ways. They are major determinants of membrane excitability, influencing the resting potential of membranes, wave forms and frequencies of action potentials, and thresholds of excitation. Voltage-gated K+ cannels exist not as independent units merely responding to changes in transmembrane potential but as macromolecular complexes able to integrate a plethora of cellular signals that fine tune channel activities. There are a wide variety of therapeutic agents that are targeted to non-K+ channels, but result in unintended block of K+ channels. This K+ channel block can result in potentially serious and sometimes even fatal side effects.

Keywords: К+ каналы, кумулятивная инактивация,сопутствующие субъеденицы, нейрональная сигнализация,генетические заболевания.

References

  1. Магура І.С., Долга О.В., Богданова Н.О. Інтегративна функція нервових клітин: роль калієвих каналів // Фізіол. журн. - 2008. - 54, №5. - С 16-22.
  2. Aldrich R.W. Inactivation of voltage-gated delayed potassium current in molluscan neurons: a kinetic model // Biophys. J. - 1981. - 36. - P. 519-532.
  3. Baukrowits T., Yellen G. Modulation of K current by frequency and external [K]: a tale of two inactivation mechanisms // Neuron. - 1995. - 15. - P. 951-960.
  4. Bezanilla F. Ion channels: from conductance to-structure // Ibid. - 2008. - 60. - P. 456-468.
  5. Bett GCL., Rasmusson R.L. Modification of K channel - drug interactions by ancillary subunits//J. Physiol. -2008. - 586. - 4. - P. 929-950.
  6. Black D.L. Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology // Cell. - 2000. - 103. -P. 367-370.
  7. Choe S. Potassium channel structures // Nat. Rev. Neurosci. - 2002. - 3 - P. 115-121.
  8. Consiglio J.F., Andalib P, Korn S.J. Influence of pore residues on permeation properties in the Kv2.1 potas­sium channel. Evidence for a selective functional in­teraction of K+ with the outer vestibule // J. Gen. Physiol. - 2003. - 2. - P. 111-124.
  9. 9. Crouzy S., Berneghe S., Roux B. Extracelluar blockade of K channels by TEA: results from molecular dynam­ics simulations of the KcsA channel // Ibid. - 2001. -18. - P. 207-217.
  10. 10. Debanne D. Plasticity of neuronal excitability in vivo // J.Physiol. - 2009. - 587, №13. - P. 3057-3058.
  11. Doyle D.A., Cabral J.M., Pfuetzner R.A., Kuo A, Gulbis J.M., Cohen S.L., Chait B.T., MacKinnon R. The structure of the potassium channel: Molecular Basis of K+ conduction and selectivity // Science. -1998. - 280. - P. 69-77.
  12. Immke D, Korn S.J. Ion-ion interaction at the selec­tivity filter. Evidence from K+-dependent modulation of tetraethylammonium efficacy in Kv2.1 potassium channels // J. Gen. Physiol. - 2000. - 115. - P. 509-518.
  13. Isom L.L., De Jongh K.S., Catterall W.A. Auxiliary subunits of voltage-gated ion channels // Neuron. -1994. - 12. - P. 1183-1194.
  14. Johnston D, Hoffman D.A., Magee J.C. Dendritic potassium channels in hippocampal pyramidal neurons // J. Physiol. - 2000. - 525, №1. - P. 75-81.
  15. Heginbotham L., MacKinnon R. The aromatic binding site for tetraethylammonium ion on potassium channels // Neuron. - 1992. - 8. - P. 483-491.-Oxford:
  16. Kostyuk P. 1998. Plasticity in nerve cell function. Cla­rendon Press, Oxford University Press. -1998. - P. - 228.
  17. Klemic K.G., Shieh C.C., Kirsch G.E., Jones S.W. Inac­tivation of Kv2.1 Potassium Channels // Biophys J. -74. - P. 1779-1789.
  18. Klemic K.G., Kirsch G.E., Jones S.W. U-type inacti­vation of Kv3.1 and Shaker potassium channels // Biophys J. - 81. -P. 814-826.
  19. 19. Ma M., Koester J. The role of K currents in frequency-dependent spike broadening in Aplysia R20 Neurons: a dynamic-clamp analysis // J. Neurosci. - 1996. - 16. -P. 4089-4102.
  20. 20. MacKinnon R. Potassium channels // FEBS Lett. -2003. - 555. - P. 62-65.
  21. MacKinnon R., Yellen. Mutation affecting TEA block­ade and ion permeation in voltage-activated K channels // Science. - 1990. - 250. - P. 276-279.
  22. MacLean J.N., Zhang Y, Johnson B.R., Harris-Warrick R.M. Activity - independent homeostasis in rhythmi­cally active neurons // Neuron. - 2003. - 37. - P. 109-120.
  23. Magura I.S., Krishtal O.A., Valeyev A.G. Behaviour of delayed current under long duration voltage clamp in snail neurons // Compar. Biochem. Physiol. - 1971. -40A. - P. 715- 722.
  24. Magura I.S., Kucher V.V., Boiko N.Y Voltage-operated potassium channels and mechanisms controlling their activity // Neurophysiology. - 2004. - 36. - P. 285-292.
  25. Magura I.S., Zamekhovsky I.Z. Repetitive firing in molluscan giant neurons // Exp. Biol. -1973. - 59. -P. 767-780.
  26. Martens J.R., O’Connell K., Tamkun M., Targeting of ion channels to membrane microdomains: localization of K channels to lipid rafts // Trends Pharmacol. Sci. -2004v. - 25. - P. 16-21.
  27. McDonald T.V., Li Y, Um S.Y Voltage - gated potas-sium channels: regulation by accessory subunits // Neuroscientist. – 2006. – 12. – P. 199–209.
  28. Miller C. An overview of the potassium channel fam­ily // Genome Biol. – 2000. – I (4).– P.0004.1–0004.5
  29. 29. Narayanan R., Johnston D. The ascent of channels with memory // Neuron. – 2008. – 60. – P. 735–738.
  30. 30. Papazian D.N. Potassium Channels: some assembly required // Ibid. – 1999. – 23. – P. 7–10.
  31. Patil P.G., Brody D.L., Yue D.T. Preferential closed-state inactivation of neuronal calcium channels // Ibid. – 1998. – 20. – P. 1027–1038.
  32. Spitzer N.C. New dimensions of neuronal plasticity / / Nat. Neuroscie. – 1999. – 2. – P. 489–490.
  33. Spruston P.J. Pyramidal neurons: dendritic structure and synaptic integration // Nat. Rev. Neurosci. – 2008. – 9. – P. 206–221.
  34. Thompson J., Begenisich T. External TEA block of shaker K+ channels is coupled to the movement of K ions within the selectivity filter // J. Gen. Physiol. – 2003. – 122. – P. 239–246.

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